Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms

Katariina Solin; Maryam Borghei; Monireh Imani; Tero Kämäräinen; Kaisa Kiri; Tapio Mäkelä; Alexey Khakalo; Hannes Orelma; Patrick Gane; Orlando Rojas

Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms

Katariina Solin
, Maryam Borghei
, Monireh Imani
, Tero Kämäräinen
, Kaisa Kiri
, Tapio Mäkelä
, Alexey Khakalo
, Hannes Orelma
, Patrick Gane
, Orlando Rojas

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Flexible and easy-to-use microfluidic systems are suitable options for point-of-care diagnostics. Here, we investigate liquid transport in fluidic channels produced by stencil printing on flexible substrates as a reproducible and scalable option for diagnostics and paper-based sensing. Optimal printability and flow profiles were obtained by combining minerals with cellulose fibrils of two different characteristic dimensions, in the nano- and microscales, forming channels with ideal wettability. Biomolecular ligands were easily added by inkjet printing on the channels, which were tested for the simultaneous detection of glucose and proteins. Accurate determination of clinically relevant concentrations was possible from linear calibration, confirming the potential of the introduced paper-based diagnostics. The results indicate the promise of simple but reliable fluidic channels for drug and chemical analyses, chromatographic separation, and quality control.

Original language	English
Pages (from-to)	5536-5546
Journal	ACS Applied Polymer Materials
Volume	3
Issue number	11
Early online date	4 Oct 2021
Publication status	Published - 12 Nov 2021
MoE publication type	A1 Journal article-refereed

Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 760876 (INNPAPER project) and the ERC Advanced Grant Agreement No. 788489, “BioElCell”. This work was a part of the Academy of Finland’s Flagship Programme under Projects Nos. 318890 and 318891 (Competence Center for Materials Bioeconomy, FinnCERES). K.S. acknowledges funding by the Aalto University School of Chemical Engineering doctoral programme. The Canada Excellence Research Chair initiative is gratefully acknowledged (OJR). The authors acknowledge the provision of facilities and technical support by Aalto University at OtaNano, Nanomicroscopy Center (Aalto-NMC).

Keywords

fluidic channel
liquid wicking materials
multisensing assay
paper-based microfluidics
stencil printing

Access to Document

http://10.1021/acsapm.1c00856Licence: CC BY

Cite this

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title = "Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms",

abstract = "Flexible and easy-to-use microfluidic systems are suitable options for point-of-care diagnostics. Here, we investigate liquid transport in fluidic channels produced by stencil printing on flexible substrates as a reproducible and scalable option for diagnostics and paper-based sensing. Optimal printability and flow profiles were obtained by combining minerals with cellulose fibrils of two different characteristic dimensions, in the nano- and microscales, forming channels with ideal wettability. Biomolecular ligands were easily added by inkjet printing on the channels, which were tested for the simultaneous detection of glucose and proteins. Accurate determination of clinically relevant concentrations was possible from linear calibration, confirming the potential of the introduced paper-based diagnostics. The results indicate the promise of simple but reliable fluidic channels for drug and chemical analyses, chromatographic separation, and quality control.",

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AU - Kämäräinen, Tero

AU - Kiri, Kaisa

AU - Mäkelä, Tapio

AU - Khakalo, Alexey

AU - Orelma, Hannes

AU - Gane, Patrick

AU - Rojas, Orlando

N1 - Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 760876 (INNPAPER project) and the ERC Advanced Grant Agreement No. 788489, “BioElCell”. This work was a part of the Academy of Finland’s Flagship Programme under Projects Nos. 318890 and 318891 (Competence Center for Materials Bioeconomy, FinnCERES). K.S. acknowledges funding by the Aalto University School of Chemical Engineering doctoral programme. The Canada Excellence Research Chair initiative is gratefully acknowledged (OJR). The authors acknowledge the provision of facilities and technical support by Aalto University at OtaNano, Nanomicroscopy Center (Aalto-NMC). Publisher Copyright: ©

PY - 2021/11/12

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N2 - Flexible and easy-to-use microfluidic systems are suitable options for point-of-care diagnostics. Here, we investigate liquid transport in fluidic channels produced by stencil printing on flexible substrates as a reproducible and scalable option for diagnostics and paper-based sensing. Optimal printability and flow profiles were obtained by combining minerals with cellulose fibrils of two different characteristic dimensions, in the nano- and microscales, forming channels with ideal wettability. Biomolecular ligands were easily added by inkjet printing on the channels, which were tested for the simultaneous detection of glucose and proteins. Accurate determination of clinically relevant concentrations was possible from linear calibration, confirming the potential of the introduced paper-based diagnostics. The results indicate the promise of simple but reliable fluidic channels for drug and chemical analyses, chromatographic separation, and quality control.

AB - Flexible and easy-to-use microfluidic systems are suitable options for point-of-care diagnostics. Here, we investigate liquid transport in fluidic channels produced by stencil printing on flexible substrates as a reproducible and scalable option for diagnostics and paper-based sensing. Optimal printability and flow profiles were obtained by combining minerals with cellulose fibrils of two different characteristic dimensions, in the nano- and microscales, forming channels with ideal wettability. Biomolecular ligands were easily added by inkjet printing on the channels, which were tested for the simultaneous detection of glucose and proteins. Accurate determination of clinically relevant concentrations was possible from linear calibration, confirming the potential of the introduced paper-based diagnostics. The results indicate the promise of simple but reliable fluidic channels for drug and chemical analyses, chromatographic separation, and quality control.

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Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

INNPAPER: Innovative and Smart Printed Electronics based on Multifunctionalized Paper: from Smart Labelling to Point of Care Bioplatforms

OtaNano

Cite this

Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Projects

INNPAPER: Innovative and Smart Printed Electronics based on Multifunctionalized Paper: from Smart Labelling to Point of Care Bioplatforms

Equipment

OtaNano

Cite this