Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome

M. Kolehmainen (Corresponding Author), O. Mykkänen, P.V. Kirjavainen, T. Leppänen, E. Moilanen, M. Adriaens, D.E. Laaksonen, M. Hallikainen, Riitta Puupponen-Pimiä, L. Pulkkinen, H. Mykkänen, H. Gylling, Kaisa Poutanen, R. Törrönen

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Scope: Low‐grade inflammation is a hallmark of cardiometabolic risk. Bilberries (Vaccinium myrtillus) are rich in polyphenols with potential anti‐inflammatory properties. We studied the impact of bilberries on inflammation and gene expression profile in peripheral blood mononuclear cells in subjects with metabolic syndrome. Methods and results: In randomized, controlled dietary intervention, the participants consumed either a diet rich in bilberries (n = 15) or a control diet (n = 12). The bilberry group consumed daily an equivalent dose of 400 g fresh bilberries, while the control group maintained their habitual diet. No differences were found between the groups in body weight, glucose, or lipid metabolism, but bilberry supplementation tended to decrease serum high‐sensitivity C‐reactive protein, IL‐6, IL‐12, and LPS concentrations. An inflammation score was significantly different between the groups (p = 0.024). In transcriptomics analyses (three participants with improved oral glucose tolerance test in the bilberry group), Toll‐like receptor signaling, cytoplasmic ribosomal proteins, and B‐cell receptor signaling pathways were differently regulated. QPCR analyses (n = 13 and 11 in the bilberry and control groups, respectively) showed decreased expression of MMD and CCR2 transcripts associated with monocyte and macrophage function associated genes. Conclusion: Regular bilberry consumption may reduce low‐grade inflammation indicating decreased cardiometabolic risk in the long term.
Original languageEnglish
Pages (from-to)1501-1510
Number of pages9
JournalMolecular Nutrition and Food Research
Volume56
Issue number10
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fingerprint

Vaccinium myrtillus
bilberries
metabolic syndrome
inflammation
Inflammation
Diet
diet
risk reduction
ribosomal proteins
Control Groups
mononuclear leukocytes
Ribosomal Proteins
anti-inflammatory activity
transcriptomics
Polyphenols
lipid metabolism
monocytes
Interleukin-12
Glucose Tolerance Test
Cytoplasmic and Nuclear Receptors

Keywords

  • Bilberry
  • gene expression
  • inflammation
  • metabolic syndrome

Cite this

Kolehmainen, M., Mykkänen, O., Kirjavainen, P. V., Leppänen, T., Moilanen, E., Adriaens, M., ... Törrönen, R. (2012). Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Molecular Nutrition and Food Research, 56(10), 1501-1510. https://doi.org/10.1002/mnfr.201200195
Kolehmainen, M. ; Mykkänen, O. ; Kirjavainen, P.V. ; Leppänen, T. ; Moilanen, E. ; Adriaens, M. ; Laaksonen, D.E. ; Hallikainen, M. ; Puupponen-Pimiä, Riitta ; Pulkkinen, L. ; Mykkänen, H. ; Gylling, H. ; Poutanen, Kaisa ; Törrönen, R. / Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. In: Molecular Nutrition and Food Research. 2012 ; Vol. 56, No. 10. pp. 1501-1510.
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abstract = "Scope: Low‐grade inflammation is a hallmark of cardiometabolic risk. Bilberries (Vaccinium myrtillus) are rich in polyphenols with potential anti‐inflammatory properties. We studied the impact of bilberries on inflammation and gene expression profile in peripheral blood mononuclear cells in subjects with metabolic syndrome. Methods and results: In randomized, controlled dietary intervention, the participants consumed either a diet rich in bilberries (n = 15) or a control diet (n = 12). The bilberry group consumed daily an equivalent dose of 400 g fresh bilberries, while the control group maintained their habitual diet. No differences were found between the groups in body weight, glucose, or lipid metabolism, but bilberry supplementation tended to decrease serum high‐sensitivity C‐reactive protein, IL‐6, IL‐12, and LPS concentrations. An inflammation score was significantly different between the groups (p = 0.024). In transcriptomics analyses (three participants with improved oral glucose tolerance test in the bilberry group), Toll‐like receptor signaling, cytoplasmic ribosomal proteins, and B‐cell receptor signaling pathways were differently regulated. QPCR analyses (n = 13 and 11 in the bilberry and control groups, respectively) showed decreased expression of MMD and CCR2 transcripts associated with monocyte and macrophage function associated genes. Conclusion: Regular bilberry consumption may reduce low‐grade inflammation indicating decreased cardiometabolic risk in the long term.",
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Kolehmainen, M, Mykkänen, O, Kirjavainen, PV, Leppänen, T, Moilanen, E, Adriaens, M, Laaksonen, DE, Hallikainen, M, Puupponen-Pimiä, R, Pulkkinen, L, Mykkänen, H, Gylling, H, Poutanen, K & Törrönen, R 2012, 'Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome', Molecular Nutrition and Food Research, vol. 56, no. 10, pp. 1501-1510. https://doi.org/10.1002/mnfr.201200195

Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. / Kolehmainen, M. (Corresponding Author); Mykkänen, O.; Kirjavainen, P.V.; Leppänen, T.; Moilanen, E.; Adriaens, M.; Laaksonen, D.E.; Hallikainen, M.; Puupponen-Pimiä, Riitta; Pulkkinen, L.; Mykkänen, H.; Gylling, H.; Poutanen, Kaisa; Törrönen, R.

In: Molecular Nutrition and Food Research, Vol. 56, No. 10, 2012, p. 1501-1510.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome

AU - Kolehmainen, M.

AU - Mykkänen, O.

AU - Kirjavainen, P.V.

AU - Leppänen, T.

AU - Moilanen, E.

AU - Adriaens, M.

AU - Laaksonen, D.E.

AU - Hallikainen, M.

AU - Puupponen-Pimiä, Riitta

AU - Pulkkinen, L.

AU - Mykkänen, H.

AU - Gylling, H.

AU - Poutanen, Kaisa

AU - Törrönen, R.

PY - 2012

Y1 - 2012

N2 - Scope: Low‐grade inflammation is a hallmark of cardiometabolic risk. Bilberries (Vaccinium myrtillus) are rich in polyphenols with potential anti‐inflammatory properties. We studied the impact of bilberries on inflammation and gene expression profile in peripheral blood mononuclear cells in subjects with metabolic syndrome. Methods and results: In randomized, controlled dietary intervention, the participants consumed either a diet rich in bilberries (n = 15) or a control diet (n = 12). The bilberry group consumed daily an equivalent dose of 400 g fresh bilberries, while the control group maintained their habitual diet. No differences were found between the groups in body weight, glucose, or lipid metabolism, but bilberry supplementation tended to decrease serum high‐sensitivity C‐reactive protein, IL‐6, IL‐12, and LPS concentrations. An inflammation score was significantly different between the groups (p = 0.024). In transcriptomics analyses (three participants with improved oral glucose tolerance test in the bilberry group), Toll‐like receptor signaling, cytoplasmic ribosomal proteins, and B‐cell receptor signaling pathways were differently regulated. QPCR analyses (n = 13 and 11 in the bilberry and control groups, respectively) showed decreased expression of MMD and CCR2 transcripts associated with monocyte and macrophage function associated genes. Conclusion: Regular bilberry consumption may reduce low‐grade inflammation indicating decreased cardiometabolic risk in the long term.

AB - Scope: Low‐grade inflammation is a hallmark of cardiometabolic risk. Bilberries (Vaccinium myrtillus) are rich in polyphenols with potential anti‐inflammatory properties. We studied the impact of bilberries on inflammation and gene expression profile in peripheral blood mononuclear cells in subjects with metabolic syndrome. Methods and results: In randomized, controlled dietary intervention, the participants consumed either a diet rich in bilberries (n = 15) or a control diet (n = 12). The bilberry group consumed daily an equivalent dose of 400 g fresh bilberries, while the control group maintained their habitual diet. No differences were found between the groups in body weight, glucose, or lipid metabolism, but bilberry supplementation tended to decrease serum high‐sensitivity C‐reactive protein, IL‐6, IL‐12, and LPS concentrations. An inflammation score was significantly different between the groups (p = 0.024). In transcriptomics analyses (three participants with improved oral glucose tolerance test in the bilberry group), Toll‐like receptor signaling, cytoplasmic ribosomal proteins, and B‐cell receptor signaling pathways were differently regulated. QPCR analyses (n = 13 and 11 in the bilberry and control groups, respectively) showed decreased expression of MMD and CCR2 transcripts associated with monocyte and macrophage function associated genes. Conclusion: Regular bilberry consumption may reduce low‐grade inflammation indicating decreased cardiometabolic risk in the long term.

KW - Bilberry

KW - gene expression

KW - inflammation

KW - metabolic syndrome

U2 - 10.1002/mnfr.201200195

DO - 10.1002/mnfr.201200195

M3 - Article

VL - 56

SP - 1501

EP - 1510

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

SN - 1613-4125

IS - 10

ER -

Kolehmainen M, Mykkänen O, Kirjavainen PV, Leppänen T, Moilanen E, Adriaens M et al. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Molecular Nutrition and Food Research. 2012;56(10):1501-1510. https://doi.org/10.1002/mnfr.201200195