Bioactive berry compounds

Novel tools against human pathogens

Research output: Contribution to journalArticleScientificpeer-review

178 Citations (Scopus)

Abstract

Berry fruits are rich sources of bioactive compounds, such as phenolics and organic acids, which have antimicrobial activities against human pathogens. Among different berries and berry phenolics, cranberry, cloudberry, raspberry, strawberry and bilberry especially possess clear antimicrobial effects against, e.g. Salmonella and Staphylococcus. Complex phenolic polymers, like ellagitannins, are strong antibacterial agents present in cloudberry and raspberry. Several mechanisms of action in the growth inhibition of bacteria are involved, such as destabilisation of cytoplasmic membrane, permeabilisation of plasma membrane, inhibition of extracellular microbial enzymes, direct actions on microbial metabolism and deprivation of the substrates required for microbial growth. Antimicrobial activity of berries may also be related to antiadherence of bacteria to epithelial cells, which is a prerequisite for colonisation and infection of many pathogens. Antimicrobial berry compounds may have important applications in the future as natural antimicrobial agents for food industry as well as for medicine. Some of the novel approaches are discussed.
Original languageEnglish
Pages (from-to)8 - 18
Number of pages11
JournalApplied Microbiology and Biotechnology
Volume67
Issue number1
DOIs
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fingerprint

Fruit
Vaccinium myrtillus
Cell Membrane
Vaccinium macrocarpon
Hydrolyzable Tannins
Bacteria
Fragaria
Food Industry
Growth
Anti-Infective Agents
Staphylococcus
Human Activities
Salmonella
Polymers
Epithelial Cells
Medicine
Anti-Bacterial Agents
Enzymes
Infection
Rubus

Keywords

  • berries
  • cranberry
  • cloudberry
  • raspberry
  • strawberry
  • bilberry
  • antimicrobial effects
  • antimicrobial agents
  • Salmonella
  • Staphylococcus
  • phenolic polymers
  • ellagitannins

Cite this

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title = "Bioactive berry compounds: Novel tools against human pathogens",
abstract = "Berry fruits are rich sources of bioactive compounds, such as phenolics and organic acids, which have antimicrobial activities against human pathogens. Among different berries and berry phenolics, cranberry, cloudberry, raspberry, strawberry and bilberry especially possess clear antimicrobial effects against, e.g. Salmonella and Staphylococcus. Complex phenolic polymers, like ellagitannins, are strong antibacterial agents present in cloudberry and raspberry. Several mechanisms of action in the growth inhibition of bacteria are involved, such as destabilisation of cytoplasmic membrane, permeabilisation of plasma membrane, inhibition of extracellular microbial enzymes, direct actions on microbial metabolism and deprivation of the substrates required for microbial growth. Antimicrobial activity of berries may also be related to antiadherence of bacteria to epithelial cells, which is a prerequisite for colonisation and infection of many pathogens. Antimicrobial berry compounds may have important applications in the future as natural antimicrobial agents for food industry as well as for medicine. Some of the novel approaches are discussed.",
keywords = "berries, cranberry, cloudberry, raspberry, strawberry, bilberry, antimicrobial effects, antimicrobial agents, Salmonella, Staphylococcus, phenolic polymers, ellagitannins",
author = "Riitta Puupponen-Pimi{\"a} and Liisa Nohynek and Hanna-Leena Alakomi and Kirsi-Marja Oksman-Caldentey",
year = "2005",
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T1 - Bioactive berry compounds

T2 - Novel tools against human pathogens

AU - Puupponen-Pimiä, Riitta

AU - Nohynek, Liisa

AU - Alakomi, Hanna-Leena

AU - Oksman-Caldentey, Kirsi-Marja

PY - 2005

Y1 - 2005

N2 - Berry fruits are rich sources of bioactive compounds, such as phenolics and organic acids, which have antimicrobial activities against human pathogens. Among different berries and berry phenolics, cranberry, cloudberry, raspberry, strawberry and bilberry especially possess clear antimicrobial effects against, e.g. Salmonella and Staphylococcus. Complex phenolic polymers, like ellagitannins, are strong antibacterial agents present in cloudberry and raspberry. Several mechanisms of action in the growth inhibition of bacteria are involved, such as destabilisation of cytoplasmic membrane, permeabilisation of plasma membrane, inhibition of extracellular microbial enzymes, direct actions on microbial metabolism and deprivation of the substrates required for microbial growth. Antimicrobial activity of berries may also be related to antiadherence of bacteria to epithelial cells, which is a prerequisite for colonisation and infection of many pathogens. Antimicrobial berry compounds may have important applications in the future as natural antimicrobial agents for food industry as well as for medicine. Some of the novel approaches are discussed.

AB - Berry fruits are rich sources of bioactive compounds, such as phenolics and organic acids, which have antimicrobial activities against human pathogens. Among different berries and berry phenolics, cranberry, cloudberry, raspberry, strawberry and bilberry especially possess clear antimicrobial effects against, e.g. Salmonella and Staphylococcus. Complex phenolic polymers, like ellagitannins, are strong antibacterial agents present in cloudberry and raspberry. Several mechanisms of action in the growth inhibition of bacteria are involved, such as destabilisation of cytoplasmic membrane, permeabilisation of plasma membrane, inhibition of extracellular microbial enzymes, direct actions on microbial metabolism and deprivation of the substrates required for microbial growth. Antimicrobial activity of berries may also be related to antiadherence of bacteria to epithelial cells, which is a prerequisite for colonisation and infection of many pathogens. Antimicrobial berry compounds may have important applications in the future as natural antimicrobial agents for food industry as well as for medicine. Some of the novel approaches are discussed.

KW - berries

KW - cranberry

KW - cloudberry

KW - raspberry

KW - strawberry

KW - bilberry

KW - antimicrobial effects

KW - antimicrobial agents

KW - Salmonella

KW - Staphylococcus

KW - phenolic polymers

KW - ellagitannins

U2 - 10.1007/s00253-004-1817-x

DO - 10.1007/s00253-004-1817-x

M3 - Article

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SP - 8

EP - 18

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

SN - 0175-7598

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ER -