Abstract
Bioactivities of bulk fish protein hydrolysates (FPH)
from defatted salmon backbones obtained with eight
different commercial enzymes and their combinations were
tested. All FPH showed antioxidative activity in vitro.
DPPH scavenging activity increased, while iron chelating
ability decreased with increasing time of hydrolysis. All
FPH showed ACE inhibiting effect which depended on type
of enzyme and increased with time of hydrolysis. The
highest effect was found for FPH produced with Trypsin.
Bromelain + Papain hydrolysates reduced the uptake of
radiolabelled glucose into CaCo-2 cells, a model of human
enterocytes, indicating a potential antidiabetic effect
of FPH. FPH obtained by Trypsin, Bromelain + Papain and
Protamex showed the highest ACE inhibitory, cellular
glucose transporter (GLUT/SGLT) inhibitory and in vitro
antioxidative activities, respectively. Correlation was
observed between the measured bioactivities, degree of
hydrolysis and molecular weight profiles, supporting
prolonged hydrolysis to obtain high bioactivities.
| Original language | English |
|---|---|
| Pages (from-to) | 99-109 |
| Journal | Biotechnology Reports |
| Volume | 11 |
| DOIs | |
| Publication status | Published - 2016 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- ACE-inhibition
- antioxidant
- fish protein hydrolysates
- clucose transport inhibition
- salmon backbones