Biocatalytic conversion of avermectin to 4″-oxo-avermectin: Improvement of cytochrome P450 monooxygenase specificity by directed evolution

Axel Trefzer, Volker Jungmann, István Molnár, Ajit Botejue, Dagmar Buckel, Gerhard Frey, D. Steven Hill, Mario Jörg, James M. Ligon, Dylan Mason, David Moore, J. Paul Pachlatko, Toby H. Richardson, Petra Spangenberg, Mark A. Wall, Ross Zirkle, Justin T. Stege (Corresponding Author)

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Chemistry

Pharmacology, Toxicology and Pharmaceutical Science