Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland

H. Koivunoro (Corresponding Author), E. Hippeläinen, I. Auterinen, L. Kankaanranta, M. Kulvik, J. Laakso, T. Seppälä, S. Savolainen, H. Joensuu

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Abstract

A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40%) had undergone surgery for newly diagnosed glioblastoma and 59 (60%) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic 18F-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood 10B concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled 10B concentrations in the tissues during neutron irradiation. The model predicts from -7% to +29% (average, +11%) change in the average tumor doses as compared with the previously estimated doses, and from 17% to 61% (average, 36%) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated 10B concentrations in the brain at the time of neutron irradiation.
Original languageEnglish
Pages (from-to)189-194
JournalApplied Radiation and Isotopes
Volume106
DOIs
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

Fingerprint

Finland
therapy
boron
brain
neutrons
tumors
dosage
neutron irradiation
surgery
blood
compartments
radiation
estimates

Keywords

  • 10B biodistribution
  • BNCT
  • BPA
  • dose calculation
  • glioma
  • PET

Cite this

Koivunoro, H. ; Hippeläinen, E. ; Auterinen, I. ; Kankaanranta, L. ; Kulvik, M. ; Laakso, J. ; Seppälä, T. ; Savolainen, S. ; Joensuu, H. / Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland. In: Applied Radiation and Isotopes. 2015 ; Vol. 106. pp. 189-194.
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title = "Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland",
abstract = "A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40{\%}) had undergone surgery for newly diagnosed glioblastoma and 59 (60{\%}) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic 18F-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood 10B concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled 10B concentrations in the tissues during neutron irradiation. The model predicts from -7{\%} to +29{\%} (average, +11{\%}) change in the average tumor doses as compared with the previously estimated doses, and from 17{\%} to 61{\%} (average, 36{\%}) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated 10B concentrations in the brain at the time of neutron irradiation.",
keywords = "10B biodistribution, BNCT, BPA, dose calculation, glioma, PET",
author = "H. Koivunoro and E. Hippel{\"a}inen and I. Auterinen and L. Kankaanranta and M. Kulvik and J. Laakso and T. Sepp{\"a}l{\"a} and S. Savolainen and H. Joensuu",
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Koivunoro, H, Hippeläinen, E, Auterinen, I, Kankaanranta, L, Kulvik, M, Laakso, J, Seppälä, T, Savolainen, S & Joensuu, H 2015, 'Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland', Applied Radiation and Isotopes, vol. 106, pp. 189-194. https://doi.org/10.1016/j.apradiso.2015.08.014

Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland. / Koivunoro, H. (Corresponding Author); Hippeläinen, E.; Auterinen, I.; Kankaanranta, L.; Kulvik, M.; Laakso, J.; Seppälä, T.; Savolainen, S.; Joensuu, H.

In: Applied Radiation and Isotopes, Vol. 106, 2015, p. 189-194.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland

AU - Koivunoro, H.

AU - Hippeläinen, E.

AU - Auterinen, I.

AU - Kankaanranta, L.

AU - Kulvik, M.

AU - Laakso, J.

AU - Seppälä, T.

AU - Savolainen, S.

AU - Joensuu, H.

PY - 2015

Y1 - 2015

N2 - A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40%) had undergone surgery for newly diagnosed glioblastoma and 59 (60%) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic 18F-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood 10B concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled 10B concentrations in the tissues during neutron irradiation. The model predicts from -7% to +29% (average, +11%) change in the average tumor doses as compared with the previously estimated doses, and from 17% to 61% (average, 36%) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated 10B concentrations in the brain at the time of neutron irradiation.

AB - A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40%) had undergone surgery for newly diagnosed glioblastoma and 59 (60%) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic 18F-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood 10B concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled 10B concentrations in the tissues during neutron irradiation. The model predicts from -7% to +29% (average, +11%) change in the average tumor doses as compared with the previously estimated doses, and from 17% to 61% (average, 36%) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated 10B concentrations in the brain at the time of neutron irradiation.

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KW - BNCT

KW - BPA

KW - dose calculation

KW - glioma

KW - PET

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U2 - 10.1016/j.apradiso.2015.08.014

DO - 10.1016/j.apradiso.2015.08.014

M3 - Article

VL - 106

SP - 189

EP - 194

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

ER -