Biomedical diagnostics enabled by integrated organic and printed electronics

Termeh Ahmadraji, Laura Gonzalez-Macia, Tapio Ritvonen, Andreas Willert, Satu Ylimaula, David Donaghy, Saara Tuurala, Mika Suhonen, Dave Smart, Aoife Morrin, Vitaly Efremov, Reinhard Baumann, Munira Raja, Antti Kemppainen, Anthony Killard (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)

Abstract

Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide and total cholesterol. The single-use device employed printed electrochemical sensors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon integrated circuits via pick and place or using organic electronic circuits. The device was capable of measuring 8 μL samples of both hydrogen peroxide (0–5 mM, 2.72 × 10–6 A·mM–1) and total cholesterol in serum from 0 to 9 mM (1.34 × 10–8 A·mM–1, r2 = 0.99, RSD < 10%, n = 3), and the result was output on a semiquantitative linear bar display. The device could operate for 10 min via a printed battery, and display the result for many hours or days. A mobile phone “app” was also capable of reading the test result and transmitting this to a remote health care provider. Such a technology could allow improved management of conditions such as hypercholesterolemia.
Original languageEnglish
Pages (from-to)7447-7454
Number of pages8
JournalAnalytical Chemistry
Volume89
Issue number14
DOIs
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed

Fingerprint

Hydrogen Peroxide
Electronic equipment
Display devices
Cholesterol
Electrochemical sensors
Networks (circuits)
Silicon
Mobile phones
Health care
Application programs
Integrated circuits

Keywords

  • printed electronics

Cite this

Ahmadraji, T., Gonzalez-Macia, L., Ritvonen, T., Willert, A., Ylimaula, S., Donaghy, D., ... Killard, A. (2017). Biomedical diagnostics enabled by integrated organic and printed electronics. Analytical Chemistry, 89(14), 7447-7454. https://doi.org/10.1021/acs.analchem.7b01012
Ahmadraji, Termeh ; Gonzalez-Macia, Laura ; Ritvonen, Tapio ; Willert, Andreas ; Ylimaula, Satu ; Donaghy, David ; Tuurala, Saara ; Suhonen, Mika ; Smart, Dave ; Morrin, Aoife ; Efremov, Vitaly ; Baumann, Reinhard ; Raja, Munira ; Kemppainen, Antti ; Killard, Anthony. / Biomedical diagnostics enabled by integrated organic and printed electronics. In: Analytical Chemistry. 2017 ; Vol. 89, No. 14. pp. 7447-7454.
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abstract = "Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide and total cholesterol. The single-use device employed printed electrochemical sensors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon integrated circuits via pick and place or using organic electronic circuits. The device was capable of measuring 8 μL samples of both hydrogen peroxide (0–5 mM, 2.72 × 10–6 A·mM–1) and total cholesterol in serum from 0 to 9 mM (1.34 × 10–8 A·mM–1, r2 = 0.99, RSD < 10{\%}, n = 3), and the result was output on a semiquantitative linear bar display. The device could operate for 10 min via a printed battery, and display the result for many hours or days. A mobile phone “app” was also capable of reading the test result and transmitting this to a remote health care provider. Such a technology could allow improved management of conditions such as hypercholesterolemia.",
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Ahmadraji, T, Gonzalez-Macia, L, Ritvonen, T, Willert, A, Ylimaula, S, Donaghy, D, Tuurala, S, Suhonen, M, Smart, D, Morrin, A, Efremov, V, Baumann, R, Raja, M, Kemppainen, A & Killard, A 2017, 'Biomedical diagnostics enabled by integrated organic and printed electronics', Analytical Chemistry, vol. 89, no. 14, pp. 7447-7454. https://doi.org/10.1021/acs.analchem.7b01012

Biomedical diagnostics enabled by integrated organic and printed electronics. / Ahmadraji, Termeh; Gonzalez-Macia, Laura; Ritvonen, Tapio; Willert, Andreas; Ylimaula, Satu; Donaghy, David; Tuurala, Saara; Suhonen, Mika; Smart, Dave; Morrin, Aoife; Efremov, Vitaly; Baumann, Reinhard; Raja, Munira; Kemppainen, Antti; Killard, Anthony (Corresponding Author).

In: Analytical Chemistry, Vol. 89, No. 14, 2017, p. 7447-7454.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Suhonen, Mika

AU - Smart, Dave

AU - Morrin, Aoife

AU - Efremov, Vitaly

AU - Baumann, Reinhard

AU - Raja, Munira

AU - Kemppainen, Antti

AU - Killard, Anthony

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