Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds

Nuria Mateo Anson (Corresponding Author), Emilia Selinheimo, Rob Havenaar, Anna-Marja Aura, Ismo Mattila, Pekka Lehtinen, Aalt Bast, Kaisa Poutanen, Guido R.M.M. Haenen

Research output: Contribution to journalArticleScientificpeer-review

144 Citations (Scopus)

Abstract

Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of phenolic compounds in bran-containing breads. The bioaccessibility of ferulic acid, p-coumaric acid, and sinapic acid was assessed with an in vitro model of upper gastrointestinal tract (TIM-1). Colonic metabolism of the phenolic compounds in the nonbioaccessible fraction of the breads was studied with an in vitro model of human colon (TIM-2). The most effective treatment was the combination of enzymes and fermentation that increased the bioaccessibility of FA from 1.1% to 5.5%. The major colonic metabolites were 3-(3-hydroxyphenyl)propionic acid and 3-phenylpropionic acid. Bran bioprocessing increases the bioaccessibility of phenolic compounds as well as the colonic end metabolite 3-phenylpropionic acid.
Original languageEnglish
Pages (from-to)6148-6155
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number14
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fingerprint

bioprocessing
bran
wheat bran
phenolic compounds
ferulic acid
metabolism
fermentation
breads
metabolites
sinapic acid
acids
p-coumaric acid
propionic acid
colon
gastrointestinal system
wheat
enzymes

Keywords

  • bioaccessibility
  • bioprocessing
  • Ferulic acid
  • phenylpropionic acid
  • wheat bran

Cite this

Mateo Anson, Nuria ; Selinheimo, Emilia ; Havenaar, Rob ; Aura, Anna-Marja ; Mattila, Ismo ; Lehtinen, Pekka ; Bast, Aalt ; Poutanen, Kaisa ; Haenen, Guido R.M.M. / Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds. In: Journal of Agricultural and Food Chemistry. 2009 ; Vol. 57, No. 14. pp. 6148-6155.
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abstract = "Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of phenolic compounds in bran-containing breads. The bioaccessibility of ferulic acid, p-coumaric acid, and sinapic acid was assessed with an in vitro model of upper gastrointestinal tract (TIM-1). Colonic metabolism of the phenolic compounds in the nonbioaccessible fraction of the breads was studied with an in vitro model of human colon (TIM-2). The most effective treatment was the combination of enzymes and fermentation that increased the bioaccessibility of FA from 1.1{\%} to 5.5{\%}. The major colonic metabolites were 3-(3-hydroxyphenyl)propionic acid and 3-phenylpropionic acid. Bran bioprocessing increases the bioaccessibility of phenolic compounds as well as the colonic end metabolite 3-phenylpropionic acid.",
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Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds. / Mateo Anson, Nuria (Corresponding Author); Selinheimo, Emilia; Havenaar, Rob; Aura, Anna-Marja; Mattila, Ismo; Lehtinen, Pekka; Bast, Aalt; Poutanen, Kaisa; Haenen, Guido R.M.M.

In: Journal of Agricultural and Food Chemistry, Vol. 57, No. 14, 2009, p. 6148-6155.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds

AU - Mateo Anson, Nuria

AU - Selinheimo, Emilia

AU - Havenaar, Rob

AU - Aura, Anna-Marja

AU - Mattila, Ismo

AU - Lehtinen, Pekka

AU - Bast, Aalt

AU - Poutanen, Kaisa

AU - Haenen, Guido R.M.M.

PY - 2009

Y1 - 2009

N2 - Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of phenolic compounds in bran-containing breads. The bioaccessibility of ferulic acid, p-coumaric acid, and sinapic acid was assessed with an in vitro model of upper gastrointestinal tract (TIM-1). Colonic metabolism of the phenolic compounds in the nonbioaccessible fraction of the breads was studied with an in vitro model of human colon (TIM-2). The most effective treatment was the combination of enzymes and fermentation that increased the bioaccessibility of FA from 1.1% to 5.5%. The major colonic metabolites were 3-(3-hydroxyphenyl)propionic acid and 3-phenylpropionic acid. Bran bioprocessing increases the bioaccessibility of phenolic compounds as well as the colonic end metabolite 3-phenylpropionic acid.

AB - Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of phenolic compounds in bran-containing breads. The bioaccessibility of ferulic acid, p-coumaric acid, and sinapic acid was assessed with an in vitro model of upper gastrointestinal tract (TIM-1). Colonic metabolism of the phenolic compounds in the nonbioaccessible fraction of the breads was studied with an in vitro model of human colon (TIM-2). The most effective treatment was the combination of enzymes and fermentation that increased the bioaccessibility of FA from 1.1% to 5.5%. The major colonic metabolites were 3-(3-hydroxyphenyl)propionic acid and 3-phenylpropionic acid. Bran bioprocessing increases the bioaccessibility of phenolic compounds as well as the colonic end metabolite 3-phenylpropionic acid.

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KW - bioprocessing

KW - Ferulic acid

KW - phenylpropionic acid

KW - wheat bran

U2 - 10.1021/jf900492h

DO - 10.1021/jf900492h

M3 - Article

VL - 57

SP - 6148

EP - 6155

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

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