BIOSMHARS: WP4 Model development and calibration - Requirements of the model: Deliverable 4.1

Ilpo Kulmala, Eero Kokkonen

    Research output: Book/ReportReport

    Abstract

    Microorganisms are constant ecological partners of humans during manned space flight in hermetically sealed environments. Although the microbes are rarely a health risk to the crew members during relatively short duration flights, increased immuno-suppression on the one hand and microgravity induced effects like enhanced pathogenicity of microbes on the other hand may threaten the crew members' health during long distance flights. In addition, there has been observed biodegradation of materials on the spacecrafts. Hence, in view of future long-duration spaceflights for exploration, it is mandatory to better understand the underlying mechanisms of biocontamination in confined environments in relation with human activities to prevent or mitigate the possible associated risks for the crew and the overall mission. This effort should rely on optimized predictive models rather than solely on empirical information. Micro-organisms can be transmitted to humans in a variety of ways, including person-to-person transmission (e.g. sexual transmission and fecal-oral contact), exposure to food-borne, water-borne, vector-borne and air-borne pathogens, and contact with contaminated objects. Of these transmission modes airborne aerosols are believed to be an important one. Therefore it would be important to be able to accurately simulate the generation, dispersion and deposition airborne microbes under conditions encountered during manned space missions. The rapid development of computational fluid dynamics (CFD) and ever increasing computer power during the past few decades has facilitated numerical methods for solving the indoor air movements and contamination transport. CFD is potentially a promising and often the only method for detailed predictions, but the accuracy of the results is affected by several factors, like the simplifications used in setting up the case, uncertainties in the initial and boundary conditions, and shortcomings of the used models. For high quality predictions the possible error sources should be recognised and the results validated.
    Original languageEnglish
    PublisherBIOSMHARS project
    Number of pages41
    Publication statusPublished - 2011
    MoE publication typeD4 Published development or research report or study

    Fingerprint

    flight
    computational fluid dynamics
    calibration
    pathogenicity
    indoor air
    prediction
    health risk
    numerical method
    biodegradation
    boundary condition
    human activity
    spacecraft
    pathogen
    microorganism
    aerosol
    food
    air
    development model
    water
    health

    Keywords

    • manned spaceflight
    • modelling
    • bioaerosol

    Cite this

    @book{7f1ce982bd0c4993a2b88e07b219fd8a,
    title = "BIOSMHARS: WP4 Model development and calibration - Requirements of the model: Deliverable 4.1",
    abstract = "Microorganisms are constant ecological partners of humans during manned space flight in hermetically sealed environments. Although the microbes are rarely a health risk to the crew members during relatively short duration flights, increased immuno-suppression on the one hand and microgravity induced effects like enhanced pathogenicity of microbes on the other hand may threaten the crew members' health during long distance flights. In addition, there has been observed biodegradation of materials on the spacecrafts. Hence, in view of future long-duration spaceflights for exploration, it is mandatory to better understand the underlying mechanisms of biocontamination in confined environments in relation with human activities to prevent or mitigate the possible associated risks for the crew and the overall mission. This effort should rely on optimized predictive models rather than solely on empirical information. Micro-organisms can be transmitted to humans in a variety of ways, including person-to-person transmission (e.g. sexual transmission and fecal-oral contact), exposure to food-borne, water-borne, vector-borne and air-borne pathogens, and contact with contaminated objects. Of these transmission modes airborne aerosols are believed to be an important one. Therefore it would be important to be able to accurately simulate the generation, dispersion and deposition airborne microbes under conditions encountered during manned space missions. The rapid development of computational fluid dynamics (CFD) and ever increasing computer power during the past few decades has facilitated numerical methods for solving the indoor air movements and contamination transport. CFD is potentially a promising and often the only method for detailed predictions, but the accuracy of the results is affected by several factors, like the simplifications used in setting up the case, uncertainties in the initial and boundary conditions, and shortcomings of the used models. For high quality predictions the possible error sources should be recognised and the results validated.",
    keywords = "manned spaceflight, modelling, bioaerosol",
    author = "Ilpo Kulmala and Eero Kokkonen",
    year = "2011",
    language = "English",
    publisher = "BIOSMHARS project",

    }

    BIOSMHARS: WP4 Model development and calibration - Requirements of the model : Deliverable 4.1. / Kulmala, Ilpo; Kokkonen, Eero.

    BIOSMHARS project, 2011. 41 p.

    Research output: Book/ReportReport

    TY - BOOK

    T1 - BIOSMHARS: WP4 Model development and calibration - Requirements of the model

    T2 - Deliverable 4.1

    AU - Kulmala, Ilpo

    AU - Kokkonen, Eero

    PY - 2011

    Y1 - 2011

    N2 - Microorganisms are constant ecological partners of humans during manned space flight in hermetically sealed environments. Although the microbes are rarely a health risk to the crew members during relatively short duration flights, increased immuno-suppression on the one hand and microgravity induced effects like enhanced pathogenicity of microbes on the other hand may threaten the crew members' health during long distance flights. In addition, there has been observed biodegradation of materials on the spacecrafts. Hence, in view of future long-duration spaceflights for exploration, it is mandatory to better understand the underlying mechanisms of biocontamination in confined environments in relation with human activities to prevent or mitigate the possible associated risks for the crew and the overall mission. This effort should rely on optimized predictive models rather than solely on empirical information. Micro-organisms can be transmitted to humans in a variety of ways, including person-to-person transmission (e.g. sexual transmission and fecal-oral contact), exposure to food-borne, water-borne, vector-borne and air-borne pathogens, and contact with contaminated objects. Of these transmission modes airborne aerosols are believed to be an important one. Therefore it would be important to be able to accurately simulate the generation, dispersion and deposition airborne microbes under conditions encountered during manned space missions. The rapid development of computational fluid dynamics (CFD) and ever increasing computer power during the past few decades has facilitated numerical methods for solving the indoor air movements and contamination transport. CFD is potentially a promising and often the only method for detailed predictions, but the accuracy of the results is affected by several factors, like the simplifications used in setting up the case, uncertainties in the initial and boundary conditions, and shortcomings of the used models. For high quality predictions the possible error sources should be recognised and the results validated.

    AB - Microorganisms are constant ecological partners of humans during manned space flight in hermetically sealed environments. Although the microbes are rarely a health risk to the crew members during relatively short duration flights, increased immuno-suppression on the one hand and microgravity induced effects like enhanced pathogenicity of microbes on the other hand may threaten the crew members' health during long distance flights. In addition, there has been observed biodegradation of materials on the spacecrafts. Hence, in view of future long-duration spaceflights for exploration, it is mandatory to better understand the underlying mechanisms of biocontamination in confined environments in relation with human activities to prevent or mitigate the possible associated risks for the crew and the overall mission. This effort should rely on optimized predictive models rather than solely on empirical information. Micro-organisms can be transmitted to humans in a variety of ways, including person-to-person transmission (e.g. sexual transmission and fecal-oral contact), exposure to food-borne, water-borne, vector-borne and air-borne pathogens, and contact with contaminated objects. Of these transmission modes airborne aerosols are believed to be an important one. Therefore it would be important to be able to accurately simulate the generation, dispersion and deposition airborne microbes under conditions encountered during manned space missions. The rapid development of computational fluid dynamics (CFD) and ever increasing computer power during the past few decades has facilitated numerical methods for solving the indoor air movements and contamination transport. CFD is potentially a promising and often the only method for detailed predictions, but the accuracy of the results is affected by several factors, like the simplifications used in setting up the case, uncertainties in the initial and boundary conditions, and shortcomings of the used models. For high quality predictions the possible error sources should be recognised and the results validated.

    KW - manned spaceflight

    KW - modelling

    KW - bioaerosol

    M3 - Report

    BT - BIOSMHARS: WP4 Model development and calibration - Requirements of the model

    PB - BIOSMHARS project

    ER -