Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 9905-9910 |
| Number of pages | 6 |
| Journal | Journal of the American Chemical Society |
| Volume | 122 |
| Issue number | 41 |
| DOIs | |
| Publication status | Published - 2000 |
| MoE publication type | Not Eligible |
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Biosynthesis of antidesmone in cell cultures of Antidesma membranaceum (Euphorbiaceae) : An unprecedented class of glycine-derived alkaloids. / Bringmann, G. (Corresponding Author); Rischer, Heiko; Wohlfarth, M.; Schlauer, J.
In: Journal of the American Chemical Society, Vol. 122, No. 41, 2000, p. 9905-9910.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Biosynthesis of antidesmone in cell cultures of Antidesma membranaceum (Euphorbiaceae)
T2 - An unprecedented class of glycine-derived alkaloids
AU - Bringmann, G.
AU - Rischer, Heiko
AU - Wohlfarth, M.
AU - Schlauer, J.
PY - 2000
Y1 - 2000
N2 - Antidesmone (3), known from several species of Antidesma and Hyeronima (Euphorbiaceae), is a quinoline alkaloid with an unusual substitution pattern. It carries a linear aliphatic side chain that indicates an at least partially acetogenic origin of the carbon skeleton. Feeding experiments with 13C and 15N labeled precursors administered to cell cultures of Antidesma membranaceum yielded antidesmone, which was investigated by NMR spectroscopy. Accordingly, antidesmone is built up from a linear C16-polyketide chain and a C2 unit derived directly from glycine. It is thus the first representative of a biosynthetically novel class of alkaloids.
AB - Antidesmone (3), known from several species of Antidesma and Hyeronima (Euphorbiaceae), is a quinoline alkaloid with an unusual substitution pattern. It carries a linear aliphatic side chain that indicates an at least partially acetogenic origin of the carbon skeleton. Feeding experiments with 13C and 15N labeled precursors administered to cell cultures of Antidesma membranaceum yielded antidesmone, which was investigated by NMR spectroscopy. Accordingly, antidesmone is built up from a linear C16-polyketide chain and a C2 unit derived directly from glycine. It is thus the first representative of a biosynthetically novel class of alkaloids.
U2 - 10.1021/ja001391k
DO - 10.1021/ja001391k
M3 - Article
VL - 122
SP - 9905
EP - 9910
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 41
ER -