Biosynthesis of antidesmone in cell cultures of Antidesma membranaceum (Euphorbiaceae): An unprecedented class of glycine-derived alkaloids

G. Bringmann (Corresponding Author), Heiko Rischer, M. Wohlfarth, J. Schlauer

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Abstract

Antidesmone (3), known from several species of Antidesma and Hyeronima (Euphorbiaceae), is a quinoline alkaloid with an unusual substitution pattern. It carries a linear aliphatic side chain that indicates an at least partially acetogenic origin of the carbon skeleton. Feeding experiments with 13C and 15N labeled precursors administered to cell cultures of Antidesma membranaceum yielded antidesmone, which was investigated by NMR spectroscopy. Accordingly, antidesmone is built up from a linear C16-polyketide chain and a C2 unit derived directly from glycine. It is thus the first representative of a biosynthetically novel class of alkaloids.
Original languageEnglish
Pages (from-to)9905-9910
Number of pages6
JournalJournal of the American Chemical Society
Volume122
Issue number41
DOIs
Publication statusPublished - 2000
MoE publication typeNot Eligible

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