Biotechnological production of glycolic acid and ethylene glycol

current state and perspectives

Research output: Contribution to journalReview ArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

Original languageEnglish
Pages (from-to)2525-2535
Number of pages11
JournalApplied Microbiology and Biotechnology
Volume103
Issue number6
DOIs
Publication statusPublished - 1 Feb 2019
MoE publication typeA2 Review article in a scientific journal

Fingerprint

glycolic acid
Ethylene Glycol
Metabolic Engineering
Metabolic Networks and Pathways
Corynebacterium glutamicum
Organic Chemicals
Carbon
Yeasts
Escherichia coli

Keywords

  • Biorefinery
  • Biotechnology
  • D-ribulose-1-phosphate pathway
  • D-xylose
  • D-xylulose-1-phosphate pathway
  • Dahms pathway
  • Ethylene glycol
  • Glycolic acid
  • Glyoxylate shunt
  • L-xylulose-1-phosphate pathway
  • Metabolic engineering
  • Serine pathway

Cite this

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title = "Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives",
abstract = "Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.",
keywords = "Biorefinery, Biotechnology, D-ribulose-1-phosphate pathway, D-xylose, D-xylulose-1-phosphate pathway, Dahms pathway, Ethylene glycol, Glycolic acid, Glyoxylate shunt, L-xylulose-1-phosphate pathway, Metabolic engineering, Serine pathway",
author = "Laura Salusj{\"a}rvi and Sami Havukainen and Outi Koivistoinen and Mervi Toivari",
year = "2019",
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doi = "10.1007/s00253-019-09640-2",
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TY - JOUR

T1 - Biotechnological production of glycolic acid and ethylene glycol

T2 - current state and perspectives

AU - Salusjärvi, Laura

AU - Havukainen, Sami

AU - Koivistoinen, Outi

AU - Toivari, Mervi

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

AB - Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

KW - Biorefinery

KW - Biotechnology

KW - D-ribulose-1-phosphate pathway

KW - D-xylose

KW - D-xylulose-1-phosphate pathway

KW - Dahms pathway

KW - Ethylene glycol

KW - Glycolic acid

KW - Glyoxylate shunt

KW - L-xylulose-1-phosphate pathway

KW - Metabolic engineering

KW - Serine pathway

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U2 - 10.1007/s00253-019-09640-2

DO - 10.1007/s00253-019-09640-2

M3 - Review Article

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SP - 2525

EP - 2535

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

SN - 0175-7598

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ER -