Biotechnological production of glycolic acid and ethylene glycol: current state and perspectives

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    16 Citations (Scopus)

    Abstract

    Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.

    Original languageEnglish
    Pages (from-to)2525-2535
    Number of pages11
    JournalApplied Microbiology and Biotechnology
    Volume103
    Issue number6
    DOIs
    Publication statusPublished - Mar 2019
    MoE publication typeA2 Review article in a scientific journal

    Keywords

    • Biorefinery
    • Biotechnology
    • D-ribulose-1-phosphate pathway
    • D-xylose
    • D-xylulose-1-phosphate pathway
    • Dahms pathway
    • Ethylene glycol
    • Glycolic acid
    • Glyoxylate shunt
    • L-xylulose-1-phosphate pathway
    • Metabolic engineering
    • Serine pathway

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