Abstract
Glycolic acid (GA) and ethylene glycol (EG) are versatile two-carbon organic chemicals used in multiple daily applications. GA and EG are currently produced by chemical synthesis, but their biotechnological production from renewable resources has received a substantial interest. Several different metabolic pathways by using genetically modified microorganisms, such as Escherichia coli, Corynebacterium glutamicum and yeast have been established for their production. As a result, the yield of GA and EG produced from sugars has been significantly improved. Here, we describe the recent advancement in metabolic engineering efforts focusing on metabolic pathways and engineering strategies used for GA and EG production.
| Original language | English |
|---|---|
| Pages (from-to) | 2525-2535 |
| Number of pages | 11 |
| Journal | Applied Microbiology and Biotechnology |
| Volume | 103 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Mar 2019 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
Open access funding provided by Technical Research Centre of Finland (VTT). This study was financially supported by the Academy of Finland through the Centre of Excellence in White Biotechnology—Green Chemistry (grant 118573) and the Pentoval project (grant 129174).
Keywords
- Biorefinery
- Biotechnology
- D-ribulose-1-phosphate pathway
- D-xylose
- D-xylulose-1-phosphate pathway
- Dahms pathway
- Ethylene glycol
- Glycolic acid
- Glyoxylate shunt
- L-xylulose-1-phosphate pathway
- Metabolic engineering
- Serine pathway