Biotechnological utilization of plant genetic resources for the production of phytopharmaceuticals

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Natural products from plants are still important sources for the development of drugs, despite their recent neglect in pharmaceutical discovery programmes. The rapidly dwindling number of species endangers the availability of these natural compounds, which are characterized by the immense chemical and functional diversity ultimately responsible for their pharmaceutical activity. Although many steps in the drug discovery process have been continuously modified during recent years, a common dilemma is still unresolved, i.e. the supply crisis for hits discovered in rare wild plants due to their inaccessibility or lack of reproducibility. New technology, combining tissue culture, functional genomics and metabolomics, shows promise to overcome these problems and even to supply a greater chemical diversity of compounds.
Original languageEnglish
Pages (from-to)83 - 89
Number of pages7
JournalPlant Genetic Resources: Characterisation and Utilisation
Volume3
Issue number2
DOIs
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fingerprint

plant genetic resources
phytopharmaceuticals
drugs
Pharmaceutical Preparations
Endangered Species
Metabolomics
Drug Discovery
Genomics
Biological Products
functional diversity
metabolomics
wild plants
reproducibility
Technology
tissue culture
genomics

Keywords

  • cell cultures
  • combinatorial biochemistry
  • functional genomics
  • metabolomics
  • plant-derived pharmaceuticals

Cite this

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title = "Biotechnological utilization of plant genetic resources for the production of phytopharmaceuticals",
abstract = "Natural products from plants are still important sources for the development of drugs, despite their recent neglect in pharmaceutical discovery programmes. The rapidly dwindling number of species endangers the availability of these natural compounds, which are characterized by the immense chemical and functional diversity ultimately responsible for their pharmaceutical activity. Although many steps in the drug discovery process have been continuously modified during recent years, a common dilemma is still unresolved, i.e. the supply crisis for hits discovered in rare wild plants due to their inaccessibility or lack of reproducibility. New technology, combining tissue culture, functional genomics and metabolomics, shows promise to overcome these problems and even to supply a greater chemical diversity of compounds.",
keywords = "cell cultures, combinatorial biochemistry, functional genomics, metabolomics, plant-derived pharmaceuticals",
author = "Heiko Rischer and Kirsi-Marja Oksman-Caldentey",
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language = "English",
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AB - Natural products from plants are still important sources for the development of drugs, despite their recent neglect in pharmaceutical discovery programmes. The rapidly dwindling number of species endangers the availability of these natural compounds, which are characterized by the immense chemical and functional diversity ultimately responsible for their pharmaceutical activity. Although many steps in the drug discovery process have been continuously modified during recent years, a common dilemma is still unresolved, i.e. the supply crisis for hits discovered in rare wild plants due to their inaccessibility or lack of reproducibility. New technology, combining tissue culture, functional genomics and metabolomics, shows promise to overcome these problems and even to supply a greater chemical diversity of compounds.

KW - cell cultures

KW - combinatorial biochemistry

KW - functional genomics

KW - metabolomics

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