TY - JOUR
T1 - Biotechnology of the medicinal plant Rhazya stricta
T2 - A little investigated member of the Apocynaceae family
AU - Akhgari, Amir
AU - Oksman-Caldentey, Kirsi-Marja
AU - Rischer, Heiko
N1 - Funding Information:
This study was financially supported by The Graduate School in Pharmaceutical Research (GSPR) and The Finnish Society of Sciences and Letters. The research leading to these results has received funding from the European Union Seventh Framework Programme FP7/2007–2013 under Grant Agreement Number 222716-SmartCell (to Kirsi-Marja Oksman-Caldentey).
Publisher Copyright:
© 2017, Springer Science+Business Media Dordrecht.
PY - 2017
Y1 - 2017
N2 - Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
AB - Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
KW - alkaloids
KW - biotechnology
KW - lipids
KW - metabolic engineering
KW - metabolites
KW - polycyclic aromatic hydrocarbons
KW - agrobacterium rhizogenes
KW - hairy roots
KW - medicinal plants
KW - plant secondary metabolites
KW - rhazya stricta
KW - terpenoid indole alkaloids
KW - transgenic roots
UR - http://www.scopus.com/inward/record.url?scp=85015157141&partnerID=8YFLogxK
U2 - 10.1007/s10529-017-2320-7
DO - 10.1007/s10529-017-2320-7
M3 - Review Article
SN - 0141-5492
VL - 39
SP - 829
EP - 840
JO - Biotechnology Letters
JF - Biotechnology Letters
IS - 6
ER -