Biotechnology of the medicinal plant Rhazya stricta

A little investigated member of the Apocynaceae family

Amir Akhgari (Corresponding Author), Kirsi-Marja Oksman-Caldentey, Heiko Rischer

Research output: Contribution to journalReview ArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
Original languageEnglish
Pages (from-to)829-840
Number of pages12
JournalBiotechnology Letters
Volume39
Issue number6
DOIs
Publication statusPublished - 2017
MoE publication typeA2 Review article in a scientific journal

Fingerprint

Secologanin Tryptamine Alkaloids
Apocynaceae
Medicinal Plants
Biotechnology
Metabolic Engineering
Middle East
Pharmacology

Keywords

  • alkaloids
  • biotechnology
  • lipids
  • metabolic engineering
  • metabolites
  • polycyclic aromatic hydrocarbons
  • agrobacterium rhizogenes
  • hairy roots
  • medicinal plants
  • plant secondary metabolites
  • rhazya stricta
  • terpenoid indole alkaloids
  • transgenic roots

Cite this

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title = "Biotechnology of the medicinal plant Rhazya stricta: A little investigated member of the Apocynaceae family",
abstract = "Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.",
keywords = "alkaloids, biotechnology, lipids, metabolic engineering, metabolites, polycyclic aromatic hydrocarbons, agrobacterium rhizogenes, hairy roots, medicinal plants, plant secondary metabolites, rhazya stricta, terpenoid indole alkaloids, transgenic roots",
author = "Amir Akhgari and Kirsi-Marja Oksman-Caldentey and Heiko Rischer",
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Biotechnology of the medicinal plant Rhazya stricta : A little investigated member of the Apocynaceae family. / Akhgari, Amir (Corresponding Author); Oksman-Caldentey, Kirsi-Marja; Rischer, Heiko.

In: Biotechnology Letters, Vol. 39, No. 6, 2017, p. 829-840.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Biotechnology of the medicinal plant Rhazya stricta

T2 - A little investigated member of the Apocynaceae family

AU - Akhgari, Amir

AU - Oksman-Caldentey, Kirsi-Marja

AU - Rischer, Heiko

PY - 2017

Y1 - 2017

N2 - Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.

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KW - alkaloids

KW - biotechnology

KW - lipids

KW - metabolic engineering

KW - metabolites

KW - polycyclic aromatic hydrocarbons

KW - agrobacterium rhizogenes

KW - hairy roots

KW - medicinal plants

KW - plant secondary metabolites

KW - rhazya stricta

KW - terpenoid indole alkaloids

KW - transgenic roots

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SP - 829

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JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

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ER -