Biotechnology of the medicinal plant Rhazya stricta: A little investigated member of the Apocynaceae family

Amir Akhgari (Corresponding Author), Kirsi-Marja Oksman-Caldentey, Heiko Rischer

Research output: Contribution to journalReview ArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
Original languageEnglish
Pages (from-to)829-840
Number of pages12
JournalBiotechnology Letters
Volume39
Issue number6
DOIs
Publication statusPublished - 2017
MoE publication typeA2 Review article in a scientific journal

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Keywords

  • alkaloids
  • biotechnology
  • lipids
  • metabolic engineering
  • metabolites
  • polycyclic aromatic hydrocarbons
  • agrobacterium rhizogenes
  • hairy roots
  • medicinal plants
  • plant secondary metabolites
  • rhazya stricta
  • terpenoid indole alkaloids
  • transgenic roots

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