Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Suvi T. Häkkinen, Heli Nygren, Natalia Maiorova, Raisa Haavikko, Sami Alakurtti, Jari Yli-Kauhaluoma, Heiko Rischer, Kirsi Marja Oksman-Caldentey

Research output: Contribution to journalArticleScientificpeer-review


In this study, three semisynthetic betulonic acid-based compounds, 20(29)-dihydrolup-2-en[2,3- d ]isoxazol-28-oic acid, 1-betulonoylpyrrolidine, and lupa-2,20(29)-dieno[2,3- b ]pyrazin-28-oic acid, were studied in biotransformation experiments using Nicotiana tabacum and Catharanthus roseus cell suspension cultures. Biotransformation was performed using cyclodextrin to aid dissolving poorly water-soluble substrates. Several new derivatives were found, consisting of oxidized and glycosylated (pentose- and hexose-conjugated) products.

Original languageEnglish
Pages (from-to)743-748
Number of pages6
JournalPlanta Medica
Issue number9-10
Publication statusPublished - 1 Jul 2018
MoE publication typeA1 Journal article-refereed


  • Apocynaceae
  • betulinic acid
  • biotransformation
  • Catharanthus roseus
  • Nicotiana tabacum
  • Solanaceae

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