Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Suvi T. Häkkinen, Heli Nygren, Natalia Maiorova, Raisa Haavikko, Sami Alakurtti, Jari Yli-Kauhaluoma, Heiko Rischer, Kirsi Marja Oksman-Caldentey

    Research output: Contribution to journalArticleScientificpeer-review

    2 Citations (Scopus)


    In this study, three semisynthetic betulonic acid-based compounds, 20(29)-dihydrolup-2-en[2,3- d ]isoxazol-28-oic acid, 1-betulonoylpyrrolidine, and lupa-2,20(29)-dieno[2,3- b ]pyrazin-28-oic acid, were studied in biotransformation experiments using Nicotiana tabacum and Catharanthus roseus cell suspension cultures. Biotransformation was performed using cyclodextrin to aid dissolving poorly water-soluble substrates. Several new derivatives were found, consisting of oxidized and glycosylated (pentose- and hexose-conjugated) products.

    Original languageEnglish
    Pages (from-to)743-748
    Number of pages6
    JournalPlanta Medica
    Issue number9-10
    Publication statusPublished - 1 Jul 2018
    MoE publication typeA1 Journal article-refereed


    • Apocynaceae
    • betulinic acid
    • biotransformation
    • Catharanthus roseus
    • Nicotiana tabacum
    • Solanaceae


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