Blood–nanomaterials interactions

Tatiana Avsievich; Ruixue Zhu; Alexey Popov; Alexander Bykov; Igor Meglinski

doi:10.1016/B978-0-12-823971-1.00002-7

Blood–nanomaterials interactions

Tatiana Avsievich, Ruixue Zhu, Alexey Popov, Alexander Bykov, Igor Meglinski

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Research output: Chapter in Book/Report/Conference proceeding › Chapter or book article › Scientific › peer-review

3 Citations (Scopus)

Abstract

Due to an overwhelming amount of nanoparticles (NPs) used in modern industry and medicine, human exposure to NPs is inevitable, raising safety concerns of their application. Blood–NP interactions appear after NP internalization into the human body regardless of the uptake route. The interaction mode of NPs with blood depends on NPs’ intrinsic properties and is largely affected by the physiological environment, making it hard to relate observed effects with these factors. In the present chapter NP interactions and the following outcomes were revised separately for the main blood components: plasma proteins, leukocytes, platelets, and red blood cells. Possible toxic effects along with approaches to avoid them were also described for each blood component.

Original language	English
Title of host publication	Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood
Publisher	Elsevier
Chapter	1
Pages	1-40
ISBN (Print)	978-0-12-823971-1
DOIs	https://doi.org/10.1016/B978-0-12-823971-1.00002-7
Publication status	Published - 2021
MoE publication type	A3 Part of a book or another research book

Keywords

Blood
Hemocompatibility
Leukocytes
Nanoparticles
Plasma proteins
Platelets
Red blood cells
Toxicity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-823971-1.00002-7

https://linkinghub.elsevier.com/retrieve/pii/B9780128239711000027

Cite this

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title = "Blood–nanomaterials interactions",

abstract = "Due to an overwhelming amount of nanoparticles (NPs) used in modern industry and medicine, human exposure to NPs is inevitable, raising safety concerns of their application. Blood–NP interactions appear after NP internalization into the human body regardless of the uptake route. The interaction mode of NPs with blood depends on NPs{\textquoteright} intrinsic properties and is largely affected by the physiological environment, making it hard to relate observed effects with these factors. In the present chapter NP interactions and the following outcomes were revised separately for the main blood components: plasma proteins, leukocytes, platelets, and red blood cells. Possible toxic effects along with approaches to avoid them were also described for each blood component.",

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year = "2021",

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language = "English",

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T1 - Blood–nanomaterials interactions

AU - Avsievich, Tatiana

AU - Zhu, Ruixue

AU - Popov, Alexey

AU - Bykov, Alexander

AU - Meglinski, Igor

PY - 2021

Y1 - 2021

N2 - Due to an overwhelming amount of nanoparticles (NPs) used in modern industry and medicine, human exposure to NPs is inevitable, raising safety concerns of their application. Blood–NP interactions appear after NP internalization into the human body regardless of the uptake route. The interaction mode of NPs with blood depends on NPs’ intrinsic properties and is largely affected by the physiological environment, making it hard to relate observed effects with these factors. In the present chapter NP interactions and the following outcomes were revised separately for the main blood components: plasma proteins, leukocytes, platelets, and red blood cells. Possible toxic effects along with approaches to avoid them were also described for each blood component.

AB - Due to an overwhelming amount of nanoparticles (NPs) used in modern industry and medicine, human exposure to NPs is inevitable, raising safety concerns of their application. Blood–NP interactions appear after NP internalization into the human body regardless of the uptake route. The interaction mode of NPs with blood depends on NPs’ intrinsic properties and is largely affected by the physiological environment, making it hard to relate observed effects with these factors. In the present chapter NP interactions and the following outcomes were revised separately for the main blood components: plasma proteins, leukocytes, platelets, and red blood cells. Possible toxic effects along with approaches to avoid them were also described for each blood component.

KW - Blood

KW - Hemocompatibility

KW - Leukocytes

KW - Nanoparticles

KW - Plasma proteins

KW - Platelets

KW - Red blood cells

KW - Toxicity

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U2 - 10.1016/B978-0-12-823971-1.00002-7

DO - 10.1016/B978-0-12-823971-1.00002-7

M3 - Chapter or book article

SN - 978-0-12-823971-1

SP - 1

EP - 40

BT - Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood

PB - Elsevier

ER -

Blood–nanomaterials interactions

Abstract

Keywords

UN SDGs

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