Boron detection from blood samples by ICP-AES and ICP-MS during boron neutron capture therapy

S. Linko, H. Revitzer, Riitta Zilliacus, Mika Kortesniemi, M. Kouri, S. Savolainen

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Objective. The concept of boron neutron capture therapy (BNCT) involves infusion of a 10B containing tracer into the patient's bloodstream followed by local neutron irradiation(s). Accurate estimation of the blood boron level for the treatment field before irradiation is required. Boron concentration can be quantified by inductively coupled plasma atomic emission spectrometry (ICP‐AES), mass spectrometry (ICP‐MS), spectrofluorometric and direct current atomic emission spectrometry (DCP‐AES) or by prompt gamma photon detection methods. Material and methods. The blood boron concentrations were analysed and compared using ICP‐AES and ICP‐MS to ensure congruency of the results if the analysis had to be changed during the treatment, e.g. for technical reasons. The effect of wet‐ashing on the results was studied in addition. Results. The mean of all samples analysed with ICP‐MS was 5.8 % lower than with ICP‐AES coupled to wet‐ashing (R2 = 0.88). Without wet‐ashing, the mean of all samples analysed with ICP‐MS was 9.1 % higher than with ICP‐AES (R2 = 0.99). Conclusions. Boron concentration analysed from whole blood samples with ICP‐AES correlated well with the values of ICP‐MS with wet‐ashing of the sample matrix, which is generally considered the reference method. When using these methods in parallel at certain intervals during the treatments, reliability of the blood boron concentration values remains satisfactory, taking into account the required accuracy of dose determination in the irradiation of cancer patients.
Original languageEnglish
Pages (from-to)696-702
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume68
Issue number8
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

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Boron Neutron Capture Therapy
Boron
Inductively coupled plasma
Spectrum Analysis
Neutrons
Blood
Spectrometry
Mass spectrometry
Mass Spectrometry
Irradiation
Neutron irradiation
Photons
Dosimetry
Therapeutics

Cite this

Linko, S. ; Revitzer, H. ; Zilliacus, Riitta ; Kortesniemi, Mika ; Kouri, M. ; Savolainen, S. / Boron detection from blood samples by ICP-AES and ICP-MS during boron neutron capture therapy. In: Scandinavian Journal of Clinical and Laboratory Investigation. 2008 ; Vol. 68, No. 8. pp. 696-702.
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title = "Boron detection from blood samples by ICP-AES and ICP-MS during boron neutron capture therapy",
abstract = "Objective. The concept of boron neutron capture therapy (BNCT) involves infusion of a 10B containing tracer into the patient's bloodstream followed by local neutron irradiation(s). Accurate estimation of the blood boron level for the treatment field before irradiation is required. Boron concentration can be quantified by inductively coupled plasma atomic emission spectrometry (ICP‐AES), mass spectrometry (ICP‐MS), spectrofluorometric and direct current atomic emission spectrometry (DCP‐AES) or by prompt gamma photon detection methods. Material and methods. The blood boron concentrations were analysed and compared using ICP‐AES and ICP‐MS to ensure congruency of the results if the analysis had to be changed during the treatment, e.g. for technical reasons. The effect of wet‐ashing on the results was studied in addition. Results. The mean of all samples analysed with ICP‐MS was 5.8 {\%} lower than with ICP‐AES coupled to wet‐ashing (R2 = 0.88). Without wet‐ashing, the mean of all samples analysed with ICP‐MS was 9.1 {\%} higher than with ICP‐AES (R2 = 0.99). Conclusions. Boron concentration analysed from whole blood samples with ICP‐AES correlated well with the values of ICP‐MS with wet‐ashing of the sample matrix, which is generally considered the reference method. When using these methods in parallel at certain intervals during the treatments, reliability of the blood boron concentration values remains satisfactory, taking into account the required accuracy of dose determination in the irradiation of cancer patients.",
author = "S. Linko and H. Revitzer and Riitta Zilliacus and Mika Kortesniemi and M. Kouri and S. Savolainen",
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Boron detection from blood samples by ICP-AES and ICP-MS during boron neutron capture therapy. / Linko, S.; Revitzer, H.; Zilliacus, Riitta; Kortesniemi, Mika; Kouri, M.; Savolainen, S.

In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 68, No. 8, 2008, p. 696-702.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Boron detection from blood samples by ICP-AES and ICP-MS during boron neutron capture therapy

AU - Linko, S.

AU - Revitzer, H.

AU - Zilliacus, Riitta

AU - Kortesniemi, Mika

AU - Kouri, M.

AU - Savolainen, S.

PY - 2008

Y1 - 2008

N2 - Objective. The concept of boron neutron capture therapy (BNCT) involves infusion of a 10B containing tracer into the patient's bloodstream followed by local neutron irradiation(s). Accurate estimation of the blood boron level for the treatment field before irradiation is required. Boron concentration can be quantified by inductively coupled plasma atomic emission spectrometry (ICP‐AES), mass spectrometry (ICP‐MS), spectrofluorometric and direct current atomic emission spectrometry (DCP‐AES) or by prompt gamma photon detection methods. Material and methods. The blood boron concentrations were analysed and compared using ICP‐AES and ICP‐MS to ensure congruency of the results if the analysis had to be changed during the treatment, e.g. for technical reasons. The effect of wet‐ashing on the results was studied in addition. Results. The mean of all samples analysed with ICP‐MS was 5.8 % lower than with ICP‐AES coupled to wet‐ashing (R2 = 0.88). Without wet‐ashing, the mean of all samples analysed with ICP‐MS was 9.1 % higher than with ICP‐AES (R2 = 0.99). Conclusions. Boron concentration analysed from whole blood samples with ICP‐AES correlated well with the values of ICP‐MS with wet‐ashing of the sample matrix, which is generally considered the reference method. When using these methods in parallel at certain intervals during the treatments, reliability of the blood boron concentration values remains satisfactory, taking into account the required accuracy of dose determination in the irradiation of cancer patients.

AB - Objective. The concept of boron neutron capture therapy (BNCT) involves infusion of a 10B containing tracer into the patient's bloodstream followed by local neutron irradiation(s). Accurate estimation of the blood boron level for the treatment field before irradiation is required. Boron concentration can be quantified by inductively coupled plasma atomic emission spectrometry (ICP‐AES), mass spectrometry (ICP‐MS), spectrofluorometric and direct current atomic emission spectrometry (DCP‐AES) or by prompt gamma photon detection methods. Material and methods. The blood boron concentrations were analysed and compared using ICP‐AES and ICP‐MS to ensure congruency of the results if the analysis had to be changed during the treatment, e.g. for technical reasons. The effect of wet‐ashing on the results was studied in addition. Results. The mean of all samples analysed with ICP‐MS was 5.8 % lower than with ICP‐AES coupled to wet‐ashing (R2 = 0.88). Without wet‐ashing, the mean of all samples analysed with ICP‐MS was 9.1 % higher than with ICP‐AES (R2 = 0.99). Conclusions. Boron concentration analysed from whole blood samples with ICP‐AES correlated well with the values of ICP‐MS with wet‐ashing of the sample matrix, which is generally considered the reference method. When using these methods in parallel at certain intervals during the treatments, reliability of the blood boron concentration values remains satisfactory, taking into account the required accuracy of dose determination in the irradiation of cancer patients.

U2 - 10.1080/00365510802100831

DO - 10.1080/00365510802100831

M3 - Article

VL - 68

SP - 696

EP - 702

JO - Scandinavian Journal of Clinical and Laboratory Investigation

JF - Scandinavian Journal of Clinical and Laboratory Investigation

SN - 0036-5513

IS - 8

ER -