Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Sauli Savolainen, Mika Kortesniemi, Marjut Timonen, Vappu Reijonen, Linda Kuusela, Jouni Uusi-Simola, Eero Salli, Hanna Koivunoro, Tiina Seppälä, Nadja Lönnroth, Petteri Välimäki, Heini Hyvönen, Petri Kotiluoto, Tom Serén, Antti Kuronen, Sami Heikkinen, Antti Kosunen, Iiro Auterinen

    Research output: Contribution to journalArticleScientificpeer-review

    30 Citations (Scopus)

    Abstract

    Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

    Original languageEnglish
    Pages (from-to)233-248
    Number of pages16
    JournalPhysica Medica
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2013
    MoE publication typeA1 Journal article-refereed

      Fingerprint

    Keywords

    • Beam dosimetry
    • Boron imaging and determination
    • Diffusion imaging
    • Dose calculation
    • Image registration
    • Neutron dosimetry
    • Neutron sources
    • Treatment planning

    Cite this

    Savolainen, S., Kortesniemi, M., Timonen, M., Reijonen, V., Kuusela, L., Uusi-Simola, J., Salli, E., Koivunoro, H., Seppälä, T., Lönnroth, N., Välimäki, P., Hyvönen, H., Kotiluoto, P., Serén, T., Kuronen, A., Heikkinen, S., Kosunen, A., & Auterinen, I. (2013). Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences. Physica Medica, 29(3), 233-248. https://doi.org/10.1016/j.ejmp.2012.04.008