Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Sauli Savolainen, Mika Kortesniemi, Marjut Timonen, Vappu Reijonen, Linda Kuusela, Jouni Uusi-Simola, Eero Salli, Hanna Koivunoro, Tiina Seppälä, Nadja Lönnroth, Petteri Välimäki, Heini Hyvönen, Petri Kotiluoto, Tom Serén, Antti Kuronen, Sami Heikkinen, Antti Kosunen, Iiro Auterinen

    Research output: Contribution to journalArticleScientificpeer-review

    29 Citations (Scopus)

    Abstract

    Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

    Original languageEnglish
    Pages (from-to)233-248
    Number of pages16
    JournalPhysica Medica
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2013
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Boron Neutron Capture Therapy
    Finland
    therapy
    boron
    neutrons
    Preceptorship
    Boron
    Physics
    Neutrons
    neutron sources
    Radiotherapy
    Therapeutics
    Clinical Trials
    dosimeters
    planning
    radiation therapy
    tumors
    Research
    physics
    Neoplasms

    Keywords

    • Beam dosimetry
    • Boron imaging and determination
    • Diffusion imaging
    • Dose calculation
    • Image registration
    • Neutron dosimetry
    • Neutron sources
    • Treatment planning

    Cite this

    Savolainen, Sauli ; Kortesniemi, Mika ; Timonen, Marjut ; Reijonen, Vappu ; Kuusela, Linda ; Uusi-Simola, Jouni ; Salli, Eero ; Koivunoro, Hanna ; Seppälä, Tiina ; Lönnroth, Nadja ; Välimäki, Petteri ; Hyvönen, Heini ; Kotiluoto, Petri ; Serén, Tom ; Kuronen, Antti ; Heikkinen, Sami ; Kosunen, Antti ; Auterinen, Iiro. / Boron neutron capture therapy (BNCT) in Finland : Technological and physical prospects after 20 years of experiences. In: Physica Medica. 2013 ; Vol. 29, No. 3. pp. 233-248.
    @article{a851318bdb294583845d6d0b9fd817aa,
    title = "Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences",
    abstract = "Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.",
    keywords = "Beam dosimetry, Boron imaging and determination, Diffusion imaging, Dose calculation, Image registration, Neutron dosimetry, Neutron sources, Treatment planning",
    author = "Sauli Savolainen and Mika Kortesniemi and Marjut Timonen and Vappu Reijonen and Linda Kuusela and Jouni Uusi-Simola and Eero Salli and Hanna Koivunoro and Tiina Sepp{\"a}l{\"a} and Nadja L{\"o}nnroth and Petteri V{\"a}lim{\"a}ki and Heini Hyv{\"o}nen and Petri Kotiluoto and Tom Ser{\'e}n and Antti Kuronen and Sami Heikkinen and Antti Kosunen and Iiro Auterinen",
    year = "2013",
    month = "5",
    day = "1",
    doi = "10.1016/j.ejmp.2012.04.008",
    language = "English",
    volume = "29",
    pages = "233--248",
    journal = "Physica Medica",
    issn = "1120-1797",
    publisher = "Associazione Italiana di Fisica Medica",
    number = "3",

    }

    Savolainen, S, Kortesniemi, M, Timonen, M, Reijonen, V, Kuusela, L, Uusi-Simola, J, Salli, E, Koivunoro, H, Seppälä, T, Lönnroth, N, Välimäki, P, Hyvönen, H, Kotiluoto, P, Serén, T, Kuronen, A, Heikkinen, S, Kosunen, A & Auterinen, I 2013, 'Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences', Physica Medica, vol. 29, no. 3, pp. 233-248. https://doi.org/10.1016/j.ejmp.2012.04.008

    Boron neutron capture therapy (BNCT) in Finland : Technological and physical prospects after 20 years of experiences. / Savolainen, Sauli; Kortesniemi, Mika; Timonen, Marjut; Reijonen, Vappu; Kuusela, Linda; Uusi-Simola, Jouni; Salli, Eero; Koivunoro, Hanna; Seppälä, Tiina; Lönnroth, Nadja; Välimäki, Petteri; Hyvönen, Heini; Kotiluoto, Petri; Serén, Tom; Kuronen, Antti; Heikkinen, Sami; Kosunen, Antti; Auterinen, Iiro.

    In: Physica Medica, Vol. 29, No. 3, 01.05.2013, p. 233-248.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Boron neutron capture therapy (BNCT) in Finland

    T2 - Technological and physical prospects after 20 years of experiences

    AU - Savolainen, Sauli

    AU - Kortesniemi, Mika

    AU - Timonen, Marjut

    AU - Reijonen, Vappu

    AU - Kuusela, Linda

    AU - Uusi-Simola, Jouni

    AU - Salli, Eero

    AU - Koivunoro, Hanna

    AU - Seppälä, Tiina

    AU - Lönnroth, Nadja

    AU - Välimäki, Petteri

    AU - Hyvönen, Heini

    AU - Kotiluoto, Petri

    AU - Serén, Tom

    AU - Kuronen, Antti

    AU - Heikkinen, Sami

    AU - Kosunen, Antti

    AU - Auterinen, Iiro

    PY - 2013/5/1

    Y1 - 2013/5/1

    N2 - Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

    AB - Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

    KW - Beam dosimetry

    KW - Boron imaging and determination

    KW - Diffusion imaging

    KW - Dose calculation

    KW - Image registration

    KW - Neutron dosimetry

    KW - Neutron sources

    KW - Treatment planning

    UR - http://www.scopus.com/inward/record.url?scp=84876744396&partnerID=8YFLogxK

    U2 - 10.1016/j.ejmp.2012.04.008

    DO - 10.1016/j.ejmp.2012.04.008

    M3 - Article

    C2 - 22613369

    AN - SCOPUS:84876744396

    VL - 29

    SP - 233

    EP - 248

    JO - Physica Medica

    JF - Physica Medica

    SN - 1120-1797

    IS - 3

    ER -

    Savolainen S, Kortesniemi M, Timonen M, Reijonen V, Kuusela L, Uusi-Simola J et al. Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences. Physica Medica. 2013 May 1;29(3):233-248. https://doi.org/10.1016/j.ejmp.2012.04.008