Abstract
Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.
| Original language | English |
|---|---|
| Pages (from-to) | 233-248 |
| Number of pages | 16 |
| Journal | Physica Medica |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 May 2013 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- Beam dosimetry
- Boron imaging and determination
- Diffusion imaging
- Dose calculation
- Image registration
- Neutron dosimetry
- Neutron sources
- Treatment planning
Cite this
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Boron neutron capture therapy (BNCT) in Finland : Technological and physical prospects after 20 years of experiences. / Savolainen, Sauli; Kortesniemi, Mika; Timonen, Marjut; Reijonen, Vappu; Kuusela, Linda; Uusi-Simola, Jouni; Salli, Eero; Koivunoro, Hanna; Seppälä, Tiina; Lönnroth, Nadja; Välimäki, Petteri; Hyvönen, Heini; Kotiluoto, Petri; Serén, Tom; Kuronen, Antti; Heikkinen, Sami; Kosunen, Antti; Auterinen, Iiro.
In: Physica Medica, Vol. 29, No. 3, 01.05.2013, p. 233-248.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Boron neutron capture therapy (BNCT) in Finland
T2 - Technological and physical prospects after 20 years of experiences
AU - Savolainen, Sauli
AU - Kortesniemi, Mika
AU - Timonen, Marjut
AU - Reijonen, Vappu
AU - Kuusela, Linda
AU - Uusi-Simola, Jouni
AU - Salli, Eero
AU - Koivunoro, Hanna
AU - Seppälä, Tiina
AU - Lönnroth, Nadja
AU - Välimäki, Petteri
AU - Hyvönen, Heini
AU - Kotiluoto, Petri
AU - Serén, Tom
AU - Kuronen, Antti
AU - Heikkinen, Sami
AU - Kosunen, Antti
AU - Auterinen, Iiro
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.
AB - Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.
KW - Beam dosimetry
KW - Boron imaging and determination
KW - Diffusion imaging
KW - Dose calculation
KW - Image registration
KW - Neutron dosimetry
KW - Neutron sources
KW - Treatment planning
UR - http://www.scopus.com/inward/record.url?scp=84876744396&partnerID=8YFLogxK
U2 - 10.1016/j.ejmp.2012.04.008
DO - 10.1016/j.ejmp.2012.04.008
M3 - Article
C2 - 22613369
AN - SCOPUS:84876744396
VL - 29
SP - 233
EP - 248
JO - Physica Medica
JF - Physica Medica
SN - 1120-1797
IS - 3
ER -