Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Sauli Savolainen, Mika Kortesniemi, Marjut Timonen, Vappu Reijonen, Linda Kuusela, Jouni Uusi-Simola, Eero Salli, Hanna Koivunoro, Tiina Seppälä, Nadja Lönnroth, Petteri Välimäki, Heini Hyvönen, Petri Kotiluoto, Tom Serén, Antti Kuronen, Sami Heikkinen, Antti Kosunen, Iiro Auterinen

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Abstract

Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

Original languageEnglish
Pages (from-to)233-248
Number of pages16
JournalPhysica Medica
Volume29
Issue number3
DOIs
Publication statusPublished - 1 May 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Boron Neutron Capture Therapy
Finland
therapy
boron
neutrons
Preceptorship
Boron
Physics
Neutrons
neutron sources
Radiotherapy
Therapeutics
Clinical Trials
dosimeters
planning
radiation therapy
tumors
Research
physics
Neoplasms

Keywords

  • Beam dosimetry
  • Boron imaging and determination
  • Diffusion imaging
  • Dose calculation
  • Image registration
  • Neutron dosimetry
  • Neutron sources
  • Treatment planning

Cite this

Savolainen, Sauli ; Kortesniemi, Mika ; Timonen, Marjut ; Reijonen, Vappu ; Kuusela, Linda ; Uusi-Simola, Jouni ; Salli, Eero ; Koivunoro, Hanna ; Seppälä, Tiina ; Lönnroth, Nadja ; Välimäki, Petteri ; Hyvönen, Heini ; Kotiluoto, Petri ; Serén, Tom ; Kuronen, Antti ; Heikkinen, Sami ; Kosunen, Antti ; Auterinen, Iiro. / Boron neutron capture therapy (BNCT) in Finland : Technological and physical prospects after 20 years of experiences. In: Physica Medica. 2013 ; Vol. 29, No. 3. pp. 233-248.
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Savolainen, S, Kortesniemi, M, Timonen, M, Reijonen, V, Kuusela, L, Uusi-Simola, J, Salli, E, Koivunoro, H, Seppälä, T, Lönnroth, N, Välimäki, P, Hyvönen, H, Kotiluoto, P, Serén, T, Kuronen, A, Heikkinen, S, Kosunen, A & Auterinen, I 2013, 'Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences', Physica Medica, vol. 29, no. 3, pp. 233-248. https://doi.org/10.1016/j.ejmp.2012.04.008

Boron neutron capture therapy (BNCT) in Finland : Technological and physical prospects after 20 years of experiences. / Savolainen, Sauli; Kortesniemi, Mika; Timonen, Marjut; Reijonen, Vappu; Kuusela, Linda; Uusi-Simola, Jouni; Salli, Eero; Koivunoro, Hanna; Seppälä, Tiina; Lönnroth, Nadja; Välimäki, Petteri; Hyvönen, Heini; Kotiluoto, Petri; Serén, Tom; Kuronen, Antti; Heikkinen, Sami; Kosunen, Antti; Auterinen, Iiro.

In: Physica Medica, Vol. 29, No. 3, 01.05.2013, p. 233-248.

Research output: Contribution to journalArticleScientificpeer-review

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T2 - Technological and physical prospects after 20 years of experiences

AU - Savolainen, Sauli

AU - Kortesniemi, Mika

AU - Timonen, Marjut

AU - Reijonen, Vappu

AU - Kuusela, Linda

AU - Uusi-Simola, Jouni

AU - Salli, Eero

AU - Koivunoro, Hanna

AU - Seppälä, Tiina

AU - Lönnroth, Nadja

AU - Välimäki, Petteri

AU - Hyvönen, Heini

AU - Kotiluoto, Petri

AU - Serén, Tom

AU - Kuronen, Antti

AU - Heikkinen, Sami

AU - Kosunen, Antti

AU - Auterinen, Iiro

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KW - Boron imaging and determination

KW - Diffusion imaging

KW - Dose calculation

KW - Image registration

KW - Neutron dosimetry

KW - Neutron sources

KW - Treatment planning

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DO - 10.1016/j.ejmp.2012.04.008

M3 - Article

C2 - 22613369

AN - SCOPUS:84876744396

VL - 29

SP - 233

EP - 248

JO - Physica Medica

JF - Physica Medica

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Savolainen S, Kortesniemi M, Timonen M, Reijonen V, Kuusela L, Uusi-Simola J et al. Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences. Physica Medica. 2013 May 1;29(3):233-248. https://doi.org/10.1016/j.ejmp.2012.04.008