Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Sauli Savolainen; Mika Kortesniemi; Marjut Timonen; Vappu Reijonen; Linda Kuusela; Jouni Uusi-Simola; Eero Salli; Hanna Koivunoro; Tiina Seppälä; Nadja Lönnroth; Petteri Välimäki; Heini Hyvönen; Petri Kotiluoto; Tom Serén; Antti Kuronen; Sami Heikkinen; Antti Kosunen; Iiro Auterinen

doi:10.1016/j.ejmp.2012.04.008

Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Sauli Savolainen^*
, Mika Kortesniemi
, Marjut Timonen
, Vappu Reijonen
, Linda Kuusela
, Jouni Uusi-Simola
, Eero Salli
, Hanna Koivunoro
, Tiina Seppälä
, Nadja Lönnroth
, Petteri Välimäki
, Heini Hyvönen
, Petri Kotiluoto
, Tom Serén
, Antti Kuronen
, Sami Heikkinen
, Antti Kosunen
, Iiro Auterinen

^*Corresponding author for this work

University of Helsinki
Boneca Corporation
Radiation and Nuclear Safety Authority (STUK)
VTT (former employee or external)

Research output: Contribution to journal › Article › Scientific › peer-review

77 Citations (Scopus)

Abstract

Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

Original language	English
Pages (from-to)	233-248
Number of pages	16
Journal	Physica Medica
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.ejmp.2012.04.008
Publication status	Published - 1 May 2013
MoE publication type	A1 Journal article-refereed

Funding

This work has been supported by the Academy of Finland and the State Subsidy for Helsinki University Central Hospital, Department of Radiology .

Keywords

Beam dosimetry
Boron imaging and determination
Diffusion imaging
Dose calculation
Image registration
Neutron dosimetry
Neutron sources
Treatment planning

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10.1016/j.ejmp.2012.04.008

Cite this

Savolainen, S., Kortesniemi, M., Timonen, M., Reijonen, V., Kuusela, L., Uusi-Simola, J., Salli, E., Koivunoro, H., Seppälä, T., Lönnroth, N., Välimäki, P., Hyvönen, H., Kotiluoto, P., Serén, T., Kuronen, A., Heikkinen, S., Kosunen, A., & Auterinen, I. (2013). Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences. Physica Medica, 29(3), 233-248. https://doi.org/10.1016/j.ejmp.2012.04.008

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abstract = "Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.",

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Savolainen, S, Kortesniemi, M, Timonen, M, Reijonen, V, Kuusela, L, Uusi-Simola, J, Salli, E, Koivunoro, H, Seppälä, T, Lönnroth, N, Välimäki, P, Hyvönen, H, Kotiluoto, P, Serén, T, Kuronen, A, Heikkinen, S, Kosunen, A & Auterinen, I 2013, 'Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences', Physica Medica, vol. 29, no. 3, pp. 233-248. https://doi.org/10.1016/j.ejmp.2012.04.008

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AU - Savolainen, Sauli

AU - Kortesniemi, Mika

AU - Timonen, Marjut

AU - Reijonen, Vappu

AU - Kuusela, Linda

AU - Uusi-Simola, Jouni

AU - Salli, Eero

AU - Koivunoro, Hanna

AU - Seppälä, Tiina

AU - Lönnroth, Nadja

AU - Välimäki, Petteri

AU - Hyvönen, Heini

AU - Kotiluoto, Petri

AU - Serén, Tom

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KW - Beam dosimetry

KW - Boron imaging and determination

KW - Diffusion imaging

KW - Dose calculation

KW - Image registration

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KW - Treatment planning

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Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Abstract

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Keywords

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