TY - JOUR
T1 - Brain death and postmortem organ donation
T2 - Report of a questionnaire from the CENTER-TBI study
AU - Van Veen, Ernest
AU - Van Der Jagt, Mathieu
AU - Cnossen, Maryse C.
AU - Maas, Andrew I.R.
AU - De Beaufort, Inez D.
AU - Menon, David K.
AU - Citerio, Giuseppe
AU - Stocchetti, Nino
AU - Rietdijk, Wim J.R.
AU - Van Dijck, Jeroen T.J.M.
AU - Kompanje, Erwin J.O.
AU - Ackerlund, Cecilia
AU - Adams, Hadie
AU - Agnoletti, Vanni
AU - Allanson, Judith
AU - Amrein, Krisztina
AU - Andaluz, Norberto
AU - Andelic, Nada
AU - Andreassen, Lasse
AU - Antun, Azasevac
AU - Anke, Audny
AU - Antoni, Anna
AU - Ardon, Hilko
AU - Audibert, Gérard
AU - Auslands, Kaspars
AU - Azouvi, Philippe
AU - Azzolini, Maria Luisa
AU - Baciu, Camelia
AU - Badenes, Rafael
AU - Bartels, Ronald
AU - Barzó, Pál
AU - Bauerfeind, Ursula
AU - Beauvais, Romuald
AU - Beer, Ronny
AU - Francisco, Javier Belda
AU - Bellander, Bo Michael
AU - Belli, Antonio
AU - Bellier, Rémy
AU - Benali, Habib
AU - Benard, Thierry
AU - Berardino, Maurizio
AU - Beretta, Luigi
AU - Beynon, Christopher
AU - Bilotta, Federico
AU - Binder, Harald
AU - Biqiri, Erta
AU - Blaabjerg, Morten
AU - Den Boogert, Hugo
AU - Bouzat, Pierre
AU - Ylén, Peter
AU - CENTER-TBI investigators and participants
N1 - Funding Information:
Data used in preparation of this manuscript were obtained in the context of the CENTER-TBI study, a large collaborative project, supported by the Framework 7 program of the European Union (602150). The funder had no role in the design of the study, the collection, analysis, and interpretation of data, or in writing the manuscript. DKM was supported by a Senior Investigator Award from the National Institute for Health Research (UK). The funder had no role in the design of the study, the collection, analysis, and interpretation of data, or in writing the manuscript.
Funding Information:
24 Department of Neurosurgery & Anesthesia & Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden. 25 NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, UK. 26 Intensive Care Unit, CHU Poitiers, Poitiers, France. 27 Anesthesie-Réanimation, Assistance Publique—Hopitaux de Paris, Paris, France. 28 Department of Anesthesia & ICU, AOU Città della Salute e della Scienza di Torino—Orthopedic and Trauma Center, Torino, Italy. 29 Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany. 30 Department of Neurology, Odense University Hospital, Odense, Denmark. 31 Department of Anesthesiology & Intensive Care, University Hospital of Grenoble, Grenoble, France. 32 BehaviourWorks Australia, Monash Sustainability Institute, Monash University, VIC, Australia. 33 Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia. 34 Quesgen Systems Inc., Burlingame, CA, USA. 35 Australian & New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. 36 Department of Neurosurgery, Umea University Hospital, Umea, Sweden. 37 Department of Neurosurgery, University of Pecs and MTA-PTE Clinical Neuroscience MR Research Group and Janos Szentagothai Research Centre, University of Pecs, Hungarian Brain Research Program, Pecs, Hungary. 38 Department of Medical Psychology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. 39 Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy. 40 ANZIC Research Centre, Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Vitoria, Australia. 41 Department of Neurosurgery, Hospital of Cruces, Bilbao, Spain. 42 Intensive Care and Department of Pediatric Surgery, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, the Netherlands. 43 Department of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Spain. 44 Department of Neuroscience, Azienda Ospedaliera Università di Padova, Padova, Italy. 45 NeuroIntensive Care, ASST di Monza, Monza, Italy. 46 School of Medicine and Surgery, Università Milano Bicocca, Milan, Italy. 47 Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands. 48 Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany. 49 Department of Anesthesia & Neurointensive Care, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK. 50 Movement Science Group, Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, UK. 51 School of Public Health & PM, Monash University and The Alfred Hospital, Melbourne, VIC, Australia. 52 Radiology/MRI Department, MRC Cognition and Brain Sciences Unit, Cambridge, UK. 53 Institute of Medical Psychology and Medical Sociology, Universitätsmedizin Göttingen, Göttingen, Germany. 54 Oxford University Hospitals NHS Trust, Oxford, UK. 55 Department of Neurosurgery, University of Pecs and MTA-PTE Clinical Neuroscience MR Research Group and Janos Szentagothai Research Centre, University of Pecs, Hungarian Brain Research Program (Grant No. KTIA 13 NAP-A-II/8), Pecs, Hungary. 56 Brain Physics Lab, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. 57 Intensive Care Unit, CHR Citadelle, Liège, Belgium. 58 Intensive Care Unit, CHU, Liège, Belgium. 59 Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK. 60 Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium. 61 Department of Anesthesia & Intensive Care, Maggiore Della Carità Hospital, Novara, Italy. 62 Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/11/16
Y1 - 2018/11/16
N2 - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
AB - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
KW - Brain death
KW - Ethics
KW - Postmortem organ donation
KW - Traumatic brain injury
KW - Ventricular drainage
KW - Withdrawing life-sustaining measures
KW - Brain Death
KW - Europe
KW - Humans
KW - Tissue and Organ Procurement/legislation & jurisprudence
KW - Internationality
KW - Brain Injuries, Traumatic/complications
KW - Trauma Centers/organization & administration
KW - Surveys and Questionnaires
UR - http://www.scopus.com/inward/record.url?scp=85056714365&partnerID=8YFLogxK
U2 - 10.1186/s13054-018-2241-4
DO - 10.1186/s13054-018-2241-4
M3 - Article
C2 - 30446017
AN - SCOPUS:85056714365
VL - 22
JO - Critical Care
JF - Critical Care
SN - 1364-8535
IS - 1
M1 - 306
ER -