TY - JOUR
T1 - Brain death and postmortem organ donation
T2 - Report of a questionnaire from the CENTER-TBI study
AU - Van Veen, Ernest
AU - Van Der Jagt, Mathieu
AU - Cnossen, Maryse C.
AU - Maas, Andrew I.R.
AU - De Beaufort, Inez D.
AU - Menon, David K.
AU - Citerio, Giuseppe
AU - Stocchetti, Nino
AU - Rietdijk, Wim J.R.
AU - Van Dijck, Jeroen T.J.M.
AU - Kompanje, Erwin J.O.
AU - Ackerlund, Cecilia
AU - Adams, Hadie
AU - Agnoletti, Vanni
AU - Allanson, Judith
AU - Amrein, Krisztina
AU - Andaluz, Norberto
AU - Andelic, Nada
AU - Andreassen, Lasse
AU - Antun, Azasevac
AU - Anke, Audny
AU - Antoni, Anna
AU - Ardon, Hilko
AU - Audibert, Gérard
AU - Auslands, Kaspars
AU - Azouvi, Philippe
AU - Azzolini, Maria Luisa
AU - Baciu, Camelia
AU - Badenes, Rafael
AU - Bartels, Ronald
AU - Barzó, Pál
AU - Bauerfeind, Ursula
AU - Beauvais, Romuald
AU - Beer, Ronny
AU - Francisco, Javier Belda
AU - Bellander, Bo Michael
AU - Belli, Antonio
AU - Bellier, Rémy
AU - Benali, Habib
AU - Benard, Thierry
AU - Berardino, Maurizio
AU - Beretta, Luigi
AU - Beynon, Christopher
AU - Bilotta, Federico
AU - Binder, Harald
AU - Biqiri, Erta
AU - Blaabjerg, Morten
AU - Den Boogert, Hugo
AU - Bouzat, Pierre
AU - Ylén, Peter
AU - CENTER-TBI investigators and participants
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/11/16
Y1 - 2018/11/16
N2 - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
AB - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
KW - Brain death
KW - Ethics
KW - Postmortem organ donation
KW - Traumatic brain injury
KW - Ventricular drainage
KW - Withdrawing life-sustaining measures
KW - Brain Death
KW - Europe
KW - Humans
KW - Tissue and Organ Procurement/legislation & jurisprudence
KW - Internationality
KW - Brain Injuries, Traumatic/complications
KW - Trauma Centers/organization & administration
KW - Surveys and Questionnaires
UR - http://www.scopus.com/inward/record.url?scp=85056714365&partnerID=8YFLogxK
U2 - 10.1186/s13054-018-2241-4
DO - 10.1186/s13054-018-2241-4
M3 - Article
C2 - 30446017
AN - SCOPUS:85056714365
SN - 1364-8535
VL - 22
JO - Critical Care
JF - Critical Care
IS - 1
M1 - 306
ER -