Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study

Ernest Van Veen; Mathieu Van Der Jagt; Maryse C. Cnossen; Andrew I.R. Maas; Inez D. De Beaufort; David K. Menon; Giuseppe Citerio; Nino Stocchetti; Wim J.R. Rietdijk; Jeroen T.J.M. Van Dijck; Erwin J.O. Kompanje; Peter Ylén; CENTER-TBI investigators and participants

doi:10.1186/s13054-018-2241-4

Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study

Ernest Van Veen, Mathieu Van Der Jagt, Maryse C. Cnossen, Andrew I.R. Maas, Inez D. De Beaufort, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Wim J.R. Rietdijk, Jeroen T.J.M. Van Dijck, Erwin J.O. Kompanje^*, Peter Ylén, CENTER-TBI investigators and participants

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

10 Citations (Scopus)

Abstract

Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

Original language	English
Article number	306
Journal	Critical Care
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s13054-018-2241-4
Publication status	Published - 16 Nov 2018
MoE publication type	A1 Journal article-refereed

Funding

Data used in preparation of this manuscript were obtained in the context of the CENTER-TBI study, a large collaborative project, supported by the Framework 7 program of the European Union (602150). DKM was supported by a Senior Investigator Award from the National Institute for Health Research (UK).

Keywords

Brain death
Ethics
Postmortem organ donation
Traumatic brain injury
Ventricular drainage
Withdrawing life-sustaining measures
Brain Death
Europe
Humans
Tissue and Organ Procurement/legislation & jurisprudence
Internationality
Brain Injuries, Traumatic/complications
Trauma Centers/organization & administration
Surveys and Questionnaires

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Van Veen, E., Van Der Jagt, M., Cnossen, M. C., Maas, A. I. R., De Beaufort, I. D., Menon, D. K., Citerio, G., Stocchetti, N., Rietdijk, W. J. R., Van Dijck, J. T. J. M., Kompanje, E. J. O., Ylén, P., & CENTER-TBI investigators and participants (2018). Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study. Critical Care, 22(1), Article 306. https://doi.org/10.1186/s13054-018-2241-4

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title = "Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study",

abstract = "Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.",

keywords = "Brain death, Ethics, Postmortem organ donation, Traumatic brain injury, Ventricular drainage, Withdrawing life-sustaining measures, Brain Death, Europe, Humans, Tissue and Organ Procurement/legislation & jurisprudence, Internationality, Brain Injuries, Traumatic/complications, Trauma Centers/organization & administration, Surveys and Questionnaires",

author = "{Van Veen}, Ernest and {Van Der Jagt}, Mathieu and Cnossen, {Maryse C.} and Maas, {Andrew I.R.} and {De Beaufort}, {Inez D.} and Menon, {David K.} and Giuseppe Citerio and Nino Stocchetti and Rietdijk, {Wim J.R.} and {Van Dijck}, {Jeroen T.J.M.} and Kompanje, {Erwin J.O.} and Cecilia Ackerlund and Hadie Adams and Vanni Agnoletti and Judith Allanson and Krisztina Amrein and Norberto Andaluz and Nada Andelic and Lasse Andreassen and Azasevac Antun and Audny Anke and Anna Antoni and Hilko Ardon and G{\'e}rard Audibert and Kaspars Auslands and Philippe Azouvi and Azzolini, {Maria Luisa} and Camelia Baciu and Rafael Badenes and Ronald Bartels and P{\'a}l Barz{\'o} and Ursula Bauerfeind and Romuald Beauvais and Ronny Beer and Francisco, {Javier Belda} and Bellander, {Bo Michael} and Antonio Belli and R{\'e}my Bellier and Habib Benali and Thierry Benard and Maurizio Berardino and Luigi Beretta and Christopher Beynon and Federico Bilotta and Harald Binder and Erta Biqiri and Morten Blaabjerg and {Den Boogert}, Hugo and Pierre Bouzat and Peter Yl{\'e}n and {CENTER-TBI investigators and participants}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

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doi = "10.1186/s13054-018-2241-4",

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Van Veen, E, Van Der Jagt, M, Cnossen, MC, Maas, AIR, De Beaufort, ID, Menon, DK, Citerio, G, Stocchetti, N, Rietdijk, WJR, Van Dijck, JTJM, Kompanje, EJO, Ylén, P & CENTER-TBI investigators and participants 2018, 'Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study', Critical Care, vol. 22, no. 1, 306. https://doi.org/10.1186/s13054-018-2241-4

TY - JOUR

T1 - Brain death and postmortem organ donation

T2 - Report of a questionnaire from the CENTER-TBI study

AU - Van Veen, Ernest

AU - Van Der Jagt, Mathieu

AU - Cnossen, Maryse C.

AU - Maas, Andrew I.R.

AU - De Beaufort, Inez D.

AU - Menon, David K.

AU - Citerio, Giuseppe

AU - Stocchetti, Nino

AU - Rietdijk, Wim J.R.

AU - Van Dijck, Jeroen T.J.M.

AU - Kompanje, Erwin J.O.

AU - Ackerlund, Cecilia

AU - Adams, Hadie

AU - Agnoletti, Vanni

AU - Allanson, Judith

AU - Amrein, Krisztina

AU - Andaluz, Norberto

AU - Andelic, Nada

AU - Andreassen, Lasse

AU - Antun, Azasevac

AU - Anke, Audny

AU - Antoni, Anna

AU - Ardon, Hilko

AU - Audibert, Gérard

AU - Auslands, Kaspars

AU - Azouvi, Philippe

AU - Azzolini, Maria Luisa

AU - Baciu, Camelia

AU - Badenes, Rafael

AU - Bartels, Ronald

AU - Barzó, Pál

AU - Bauerfeind, Ursula

AU - Beauvais, Romuald

AU - Beer, Ronny

AU - Francisco, Javier Belda

AU - Bellander, Bo Michael

AU - Belli, Antonio

AU - Bellier, Rémy

AU - Benali, Habib

AU - Benard, Thierry

AU - Berardino, Maurizio

AU - Beretta, Luigi

AU - Beynon, Christopher

AU - Bilotta, Federico

AU - Binder, Harald

AU - Biqiri, Erta

AU - Blaabjerg, Morten

AU - Den Boogert, Hugo

AU - Bouzat, Pierre

AU - Ylén, Peter

AU - CENTER-TBI investigators and participants

PY - 2018/11/16

Y1 - 2018/11/16

N2 - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

AB - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

KW - Brain death

KW - Ethics

KW - Postmortem organ donation

KW - Traumatic brain injury

KW - Ventricular drainage

KW - Withdrawing life-sustaining measures

KW - Brain Death

KW - Europe

KW - Humans

KW - Tissue and Organ Procurement/legislation & jurisprudence

KW - Internationality

KW - Brain Injuries, Traumatic/complications

KW - Trauma Centers/organization & administration

KW - Surveys and Questionnaires

UR - http://www.scopus.com/inward/record.url?scp=85056714365&partnerID=8YFLogxK

U2 - 10.1186/s13054-018-2241-4

DO - 10.1186/s13054-018-2241-4

M3 - Article

C2 - 30446017

AN - SCOPUS:85056714365

SN - 1364-8535

VL - 22

JO - Critical Care

JF - Critical Care

IS - 1

M1 - 306

ER -

Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study

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Keywords

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