Calcium-induced structural changes and domain autonomy in calmodulin

B. Finn, J. Evenäs, Torbjörn Drakenberg, J. Waltho, Eva Thulin, Sture Forsen

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We have determined the solution structures of the apo and (Ca2+)2 forms of the carboxy-terminal domain of calmodulin using multidimensional heteronuclear nuclear magnetic resonance spectroscopy.
The results show that both forms adopt well-defined structures with essentially equal secondary structure. A comparison of the structures of the two forms shows that Ca2+ binding causes major rearrangements of the secondary structure elements with changes in inter-residue distances of up to 15 A and exposure of the hydrophobic interior of the four-helix bundle.
Comparisons with previously determined high-resolution X-ray structures and models of calmodulin indicate that this domain is structurally autonomous.
Original languageEnglish
Pages (from-to)777-783
JournalNature Structural Biology
Issue number9
Publication statusPublished - 1995
MoE publication typeA1 Journal article-refereed

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    Finn, B., Evenäs, J., Drakenberg, T., Waltho, J., Thulin, E., & Forsen, S. (1995). Calcium-induced structural changes and domain autonomy in calmodulin. Nature Structural Biology, 2(9), 777-783.