Cancer biology, toxicology and alternative methods development go hand-in-hand

P Kohonen, R Ceder, I Smit, Vesa Hongisto, G Myatt, B Hardy, O Spjuth, R Grafström (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)

Abstract

Toxicological research faces the challenge of integrating knowledge from diverse fields and novel technological developments generally in the biological and medical sciences. We discuss herein the fact that the multiple facets of cancer research, including discovery related to mechanisms, treatment and diagnosis, overlap many up and coming interest areas in toxicology, including the need for improved methods and analysis tools. Common to both disciplines, in vitro and in silico methods serve as alternative investigation routes to animal studies. Knowledge on cancer development helps in understanding the relevance of chemical toxicity studies in cell models, and many bioinformatics-based cancer biomarker discovery tools are also applicable to computational toxicology. Robotics-aided, cell-based, high-throughput screening, microscale immunostaining techniques and gene expression profiling analyses are common tools in cancer research, and when sequentially combined, form a tiered approach to structured safety evaluation of thousands of environmental agents, novel chemicals or engineered nanomaterials. Comprehensive tumour data collections in databases have been translated into clinically useful data, and this concept serves as template for computer-driven evaluation of toxicity data into meaningful results. Future 'cancer research-inspired knowledge management' of toxicological data will aid the translation of basic discovery results and chemicals- and materials-testing data to information relevant to human health and environmental safety
Original languageEnglish
Pages (from-to)50-58
JournalBasic and Clinical Pharmacology and Toxicology
Volume115
Issue number1
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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Toxicology
Toxicity
Neoplasms
Research
Materials testing
Materials Testing
Safety
Knowledge Management
Bioinformatics
Tumor Biomarkers
Knowledge management
Nanostructured materials
Gene expression
Environmental Health
Biological Science Disciplines
Nanostructures
Robotics
Tumors
Gene Expression Profiling
Screening

Cite this

Kohonen, P., Ceder, R., Smit, I., Hongisto, V., Myatt, G., Hardy, B., ... Grafström, R. (2014). Cancer biology, toxicology and alternative methods development go hand-in-hand. Basic and Clinical Pharmacology and Toxicology, 115(1), 50-58. https://doi.org/10.1111/bcpt.12257
Kohonen, P ; Ceder, R ; Smit, I ; Hongisto, Vesa ; Myatt, G ; Hardy, B ; Spjuth, O ; Grafström, R. / Cancer biology, toxicology and alternative methods development go hand-in-hand. In: Basic and Clinical Pharmacology and Toxicology. 2014 ; Vol. 115, No. 1. pp. 50-58.
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Kohonen, P, Ceder, R, Smit, I, Hongisto, V, Myatt, G, Hardy, B, Spjuth, O & Grafström, R 2014, 'Cancer biology, toxicology and alternative methods development go hand-in-hand', Basic and Clinical Pharmacology and Toxicology, vol. 115, no. 1, pp. 50-58. https://doi.org/10.1111/bcpt.12257

Cancer biology, toxicology and alternative methods development go hand-in-hand. / Kohonen, P; Ceder, R; Smit, I; Hongisto, Vesa; Myatt, G; Hardy, B; Spjuth, O; Grafström, R (Corresponding Author).

In: Basic and Clinical Pharmacology and Toxicology, Vol. 115, No. 1, 2014, p. 50-58.

Research output: Contribution to journalArticleScientificpeer-review

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