Cenp-F (mitosin) is more than a mitotic marker

Asta Varis, Anna-Leena Salmela, Marko J. Kallio (Corresponding Author)

Research output: Contribution to journalReview Articlepeer-review

78 Citations (Scopus)


Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.
Original languageEnglish
Pages (from-to)288-295
Issue number4
Publication statusPublished - 2006
MoE publication typeA2 Review article in a scientific journal


  • mitosin
  • cell division
  • regulation


Dive into the research topics of 'Cenp-F (mitosin) is more than a mitotic marker'. Together they form a unique fingerprint.

Cite this