Cenp-F (mitosin) is more than a mitotic marker

Asta Varis, Anna-Leena Salmela, Marko J. Kallio (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

55 Citations (Scopus)

Abstract

Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.
Original languageEnglish
Pages (from-to)288-295
JournalChromosoma
Volume115
Issue number4
DOIs
Publication statusPublished - 2006
MoE publication typeA2 Review article in a scientific journal

Fingerprint

Prenylation
Kinetochores
Post Translational Protein Processing
Transferases
Cell Division
Cell Cycle
Proteins
Growth
centromere protein F

Keywords

  • mitosin
  • cell division
  • regulation

Cite this

Varis, A., Salmela, A-L., & Kallio, M. J. (2006). Cenp-F (mitosin) is more than a mitotic marker. Chromosoma, 115(4), 288-295. https://doi.org/10.1007/s00412-005-0046-0
Varis, Asta ; Salmela, Anna-Leena ; Kallio, Marko J. / Cenp-F (mitosin) is more than a mitotic marker. In: Chromosoma. 2006 ; Vol. 115, No. 4. pp. 288-295.
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Varis, A, Salmela, A-L & Kallio, MJ 2006, 'Cenp-F (mitosin) is more than a mitotic marker', Chromosoma, vol. 115, no. 4, pp. 288-295. https://doi.org/10.1007/s00412-005-0046-0

Cenp-F (mitosin) is more than a mitotic marker. / Varis, Asta; Salmela, Anna-Leena; Kallio, Marko J. (Corresponding Author).

In: Chromosoma, Vol. 115, No. 4, 2006, p. 288-295.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Cenp-F (mitosin) is more than a mitotic marker

AU - Varis, Asta

AU - Salmela, Anna-Leena

AU - Kallio, Marko J.

PY - 2006

Y1 - 2006

N2 - Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.

AB - Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.

KW - mitosin

KW - cell division

KW - regulation

U2 - 10.1007/s00412-005-0046-0

DO - 10.1007/s00412-005-0046-0

M3 - Review Article

VL - 115

SP - 288

EP - 295

JO - Chromosoma

JF - Chromosoma

SN - 0009-5915

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ER -