Cenp-F (mitosin) is more than a mitotic marker

Asta Varis, Anna-Leena Salmela, Marko J. Kallio (Corresponding Author)

Research output: Contribution to journalReview Articlepeer-review

58 Citations (Scopus)

Abstract

Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.
Original languageEnglish
Pages (from-to)288-295
JournalChromosoma
Volume115
Issue number4
DOIs
Publication statusPublished - 2006
MoE publication typeA2 Review article in a scientific journal

Keywords

  • mitosin
  • cell division
  • regulation

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