Abstract
Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.
| Original language | English |
|---|---|
| Pages (from-to) | 288-295 |
| Journal | Chromosoma |
| Volume | 115 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 |
| MoE publication type | A2 Review article in a scientific journal |
Keywords
- mitosin
- cell division
- regulation