Characterization of D-xylose reductase, XyrB, from Aspergillus niger

Agata Terebieniec, Tania Chroumpi, Adiphol Dilokpimol, Maria Victoria Aguilar-Pontes, Miia R. Mäkelä, Ronald P. de Vries

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)


D-xylose reductase is a member of the aldo-keto reductase family, and is involved in D-xylose and L-arabinose conversion through the Pentose Catabolic Pathway (PCP) in fungi. In this study, we biochemically characterized a newly identified second D-xylose reductase (XyrB) from Aspergillus niger. This NADPH-dependent reductase is able to efficiently convert D-xylose and L-arabinose, and it has the highest affinity for these sugars of all currently known fungal pentose reductases. A combination of biochemical data, transcriptomics and phylogenetic analysis further illustrated the role of XyrB in the PCP. Enzymes: D-xylose reductase (EC, L-arabinose reductase (EC

Original languageEnglish
Article numbere00610
JournalBiotechnology Reports
Publication statusPublished - Jun 2021
MoE publication typeA1 Journal article-refereed


  • Aspergillus niger
  • D-xylose reductase
  • Pentose Catabolic Pathway


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