Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer

Şükrü Tüzmen; Galen Hostetter; Aprill Watanabe; Cumhur Ekmekçi; Patricia E. Carrigan; Ishaiahu Shechter; Olli Kallioniemi; Laurence J. Miller; Spyro Mousses

doi:10.2217/pme-2016-0058

Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer

Şükrü Tüzmen^*
, Galen Hostetter
, Aprill Watanabe
, Cumhur Ekmekçi
, Patricia E. Carrigan
, Ishaiahu Shechter
, Olli Kallioniemi
, Laurence J. Miller
, Spyro Mousses

^*Corresponding author for this work

VTT Technical Research Centre of Finland

Eastern Mediterranean University
Translational Genomics Research Institute (TGen)
Van Andel Institute
Texas Tech University
Acibadem University
Mayo Clinic
Bayer AG
Uniformed Services University of the Health Sciences
VTT (former employee or external)
University of Turku
Systems Oncology

Research output: Contribution to journal › Article › Scientific › peer-review

35 Citations (Scopus)

Abstract

Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

Original language	English
Pages (from-to)	51-65
Journal	Personalized Medicine
Volume	16
Issue number	1
DOIs	https://doi.org/10.2217/pme-2016-0058
Publication status	Published - Jan 2019
MoE publication type	A1 Journal article-refereed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
cholesterol
FDFT1
gene expression
immunohistochemistry
lipidrafts
microdomains
plasma membrane
qPCR
TMA

Access to Document

10.2217/pme-2016-0058

Cite this

@article{6ee47c37395a486fa9108773c5c5c190,

title = "Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer",

abstract = "Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.",

keywords = "cancer, cholesterol, FDFT1, gene expression, immunohistochemistry, lipidrafts, microdomains, plasma membrane, qPCR, TMA",

author = "{\c S}{\"u}kr{\"u} T{\"u}zmen and Galen Hostetter and Aprill Watanabe and Cumhur Ekmek{\c c}i and Carrigan, \{Patricia E.\} and Ishaiahu Shechter and Olli Kallioniemi and Miller, \{Laurence J.\} and Spyro Mousses",

year = "2019",

month = jan,

doi = "10.2217/pme-2016-0058",

language = "English",

volume = "16",

pages = "51--65",

journal = "Personalized Medicine",

issn = "1741-0541",

publisher = "Taylor \& Francis",

number = "1",

}

TY - JOUR

T1 - Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer

AU - Tüzmen, Şükrü

AU - Hostetter, Galen

AU - Watanabe, Aprill

AU - Ekmekçi, Cumhur

AU - Carrigan, Patricia E.

AU - Shechter, Ishaiahu

AU - Kallioniemi, Olli

AU - Miller, Laurence J.

AU - Mousses, Spyro

PY - 2019/1

Y1 - 2019/1

N2 - Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

AB - Aim: To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by its synthesis in a metabolic pathway regulated by the FDFT1 enzyme. Given the critical role this might play in carcinogenesis and in the behavior of cancers, we have examined the level of this enzyme in various types of human cancer. Our demonstration of elevated levels of FDFT1 mRNA and protein in some tumors relative to surrounding normal tissue identifies this as a possible biomarker for disease development and progression, and as a potential new target for the treatment of cancer.

KW - cancer

KW - cholesterol

KW - FDFT1

KW - gene expression

KW - immunohistochemistry

KW - lipidrafts

KW - microdomains

KW - plasma membrane

KW - qPCR

KW - TMA

UR - https://www.scopus.com/pages/publications/85058745457

U2 - 10.2217/pme-2016-0058

DO - 10.2217/pme-2016-0058

M3 - Article

C2 - 30468409

AN - SCOPUS:85058745457

SN - 1741-0541

VL - 16

SP - 51

EP - 65

JO - Personalized Medicine

JF - Personalized Medicine

IS - 1

ER -

Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this