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Abstract
Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant Staphylococcus aureus was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.
Original language | English |
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Article number | 140 |
Number of pages | 11 |
Journal | Pharmaceuticals |
Volume | 16 |
Issue number | 2 |
DOIs | |
Publication status | Published - 18 Jan 2023 |
MoE publication type | A1 Journal article-refereed |
Funding
This work was financially supported by the CichOpt project funded under the ERA-NET FACCE SURPLUS, which received funding from the European Union\u2019s Horizon 2020 research, innovation programme (Grant Agreement 652615) and EU-H2020 project \u2018InnCoCells\u2019 (101000373).
Keywords
- chicory
- antimicrobial activity
- hairy roots
- sesquiterpenes
- polyphenols
- MRSA
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- 1 Active
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InnCoCells: Innovative high-value cosmetic products from plants and plant cells
Rischer, H. (Manager), Oksman-Caldentey, K.-M. (Owner), Häkkinen, S. (Participant), Nohynek, L. (Participant), Kervinen, R. (Participant), Lillberg, A. (Participant) & Akhgari, A. (Participant)
1/05/21 → 30/09/25
Project: EU project