Cleaning validation of fermentation tanks

Satu Salo, Alan Friis, Gun Wirtanen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Abstract

Reliable test methods for checking cleanliness are needed to evaluate and validate the cleaning process of fermentation tanks. The size of a fermentation tank can be several hundred cubic meters limiting the use of many traditional sampling methods since the reachable areas are scarce compared to the entire tank surface. Pilot scale tanks were used to test the applicability of various methods for evaluation of the cleanliness of fermentation tanks. The aims of this study were to find appropriate methods to detect cleanliness in pilot scale tanks, to find out which parts of the tank were difficult to clean and to optimise the cleaning procedure. This study was performed to improve the investigation of cleanability of process scale tanks and to choose suitable methods and sampling areas for use in process scale evaluations. Furthermore interpretation of data from various sampling methods is needed in cleanability assessment. The methods found to be suitable for validation of the cleanliness were visual observation of a fluorescent indicator using UV-light, a contact agar method and culturing based on swabbing and swiping with non-woven cloths. The validation of the cleaning procedure and the design of a proper cleaning system can be supported and improved using computational fluid dynamics, which through a simulation reveals areas not easily covered by the cleaning fluid. Microbial results from pilot scale studies are needed to interpret the simulation results properly. Using various methods simultaneously improves the interpretation of cleanability of tanks.
Original languageEnglish
Pages (from-to)204 - 210
Number of pages7
JournalFood and Bioproducts Processing
Volume86
Issue number3
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

cleaning
Fermentation
Cleaning
fermentation
Sampling
methodology
Ultraviolet radiation
Agar
Computational fluid dynamics
Fluids
sampling
ultraviolet radiation
Hydrodynamics
Ultraviolet Rays
fluid mechanics
agar
testing
Observation

Keywords

  • Sampling
  • Tank
  • Cleanliness

Cite this

Salo, Satu ; Friis, Alan ; Wirtanen, Gun. / Cleaning validation of fermentation tanks. In: Food and Bioproducts Processing. 2008 ; Vol. 86, No. 3. pp. 204 - 210.
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title = "Cleaning validation of fermentation tanks",
abstract = "Reliable test methods for checking cleanliness are needed to evaluate and validate the cleaning process of fermentation tanks. The size of a fermentation tank can be several hundred cubic meters limiting the use of many traditional sampling methods since the reachable areas are scarce compared to the entire tank surface. Pilot scale tanks were used to test the applicability of various methods for evaluation of the cleanliness of fermentation tanks. The aims of this study were to find appropriate methods to detect cleanliness in pilot scale tanks, to find out which parts of the tank were difficult to clean and to optimise the cleaning procedure. This study was performed to improve the investigation of cleanability of process scale tanks and to choose suitable methods and sampling areas for use in process scale evaluations. Furthermore interpretation of data from various sampling methods is needed in cleanability assessment. The methods found to be suitable for validation of the cleanliness were visual observation of a fluorescent indicator using UV-light, a contact agar method and culturing based on swabbing and swiping with non-woven cloths. The validation of the cleaning procedure and the design of a proper cleaning system can be supported and improved using computational fluid dynamics, which through a simulation reveals areas not easily covered by the cleaning fluid. Microbial results from pilot scale studies are needed to interpret the simulation results properly. Using various methods simultaneously improves the interpretation of cleanability of tanks.",
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Cleaning validation of fermentation tanks. / Salo, Satu; Friis, Alan; Wirtanen, Gun (Corresponding Author).

In: Food and Bioproducts Processing, Vol. 86, No. 3, 2008, p. 204 - 210.

Research output: Contribution to journalArticleScientificpeer-review

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AB - Reliable test methods for checking cleanliness are needed to evaluate and validate the cleaning process of fermentation tanks. The size of a fermentation tank can be several hundred cubic meters limiting the use of many traditional sampling methods since the reachable areas are scarce compared to the entire tank surface. Pilot scale tanks were used to test the applicability of various methods for evaluation of the cleanliness of fermentation tanks. The aims of this study were to find appropriate methods to detect cleanliness in pilot scale tanks, to find out which parts of the tank were difficult to clean and to optimise the cleaning procedure. This study was performed to improve the investigation of cleanability of process scale tanks and to choose suitable methods and sampling areas for use in process scale evaluations. Furthermore interpretation of data from various sampling methods is needed in cleanability assessment. The methods found to be suitable for validation of the cleanliness were visual observation of a fluorescent indicator using UV-light, a contact agar method and culturing based on swabbing and swiping with non-woven cloths. The validation of the cleaning procedure and the design of a proper cleaning system can be supported and improved using computational fluid dynamics, which through a simulation reveals areas not easily covered by the cleaning fluid. Microbial results from pilot scale studies are needed to interpret the simulation results properly. Using various methods simultaneously improves the interpretation of cleanability of tanks.

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