@article{d9115b6317704ce98f762b8ef84be805,
title = "Colon cancer detection by using Poincar{\'e} sphere and 2D polarimetric mapping of ex vivo colon samples",
abstract = "This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincar{\'e} sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincar{\'e} sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.",
keywords = "colon cancer, Poincar{\'e} sphere, polarimetric mapping, stokes polarimetry, tissue diagnostics",
author = "Deyan Ivanov and Viktor Dremin and Alexander Bykov and Ekaterina Borisova and Tsanislava Genova and Alexey Popov and Razvigor Ossikovski and Tatiana Novikova and Igor Meglinski",
note = "Funding Information: 3 The polarimetric investigations were supported by NSFB‐MES project #KP06‐N28/11/14.12.2018. The authors also acknowledge the support of the Academy of Finland (grants: 314369 and 325097). This study was also supported by the Russian Science Foundation under projects No. 19‐79‐00082 (experimental data collection) and project No. 18‐15‐00139 (samples selection and preparation). Professor Meglinski acknowledges support from MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005) and the National Research Tomsk State University Academic D.I. Mendeleev Fund Program. This project has also received funding from the ATTRACT project funded by the EU under Grant Agreement 777222. T. Novikova, R.Ossikovski and E. Borisova acknowledged the contribution from bilateral project POLHIS, program Campus France PHC RILA, n 38660WH & DNTS/France 01/7‐09/05/2017 “Polarization optical histology of tumors.” Authors are sincerely thankful to Ms. Mariia Borovkova for the contribution in preparation of Figure . Funding Information: The polarimetric investigations were supported by NSFB-MES project #KP06-N28/11/14.12.2018. The authors also acknowledge the support of the Academy of Finland (grants: 314369 and 325097). This study was also supported by the Russian Science Foundation under projects No. 19-79-00082 (experimental data collection) and project No. 18-15-00139 (samples selection and preparation). Professor Meglinski acknowledges support from MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005) and the National Research Tomsk State University Academic D.I. Mendeleev Fund Program. This project has also received funding from the ATTRACT project funded by the EU under Grant Agreement 777222. T. Novikova, R.Ossikovski and E. Borisova acknowledged the contribution from bilateral project POLHIS, program Campus France PHC RILA, n 38660WH & DNTS/France 01/7-09/05/2017 ?Polarization optical histology of tumors.? Authors are sincerely thankful to Ms. Mariia Borovkova for the contribution in preparation of Figure 3. Publisher Copyright: {\textcopyright} 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = aug,
doi = "10.1002/jbio.202000082",
language = "English",
volume = "13",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley-VCH Verlag",
number = "8",
}
