Combined synthesis and in situ coating of nanoparticles in the gas phase

Anna Lähde, Janne Raula, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)


Combined gas phase synthesis and coating of sodium chloride (NaCl) and lactose nanoparticles has been developed using an aerosol flow reactor. Nano-sized core particles were produced by the droplet-to-particle method and coated in situ by the physical vapour deposition of L-leucine vapour. The saturation of L-leucine in the reactor determined the resulting particle size and size distribution. In general, particle size increased with the addition of L-leucine and notable narrowing of the core particle size distribution was observed. In addition, homogeneous nucleation of the vapour, i.e. formation of pure L-leucine particles, was observed depending on the saturation conditions of L-leucine as well as the core particle characteristics. The effects of core particle properties, i.e. size and solid-state characteristics, on the coating process were studied by comparing the results for coated NaCl and lactose particles. During deposition, L-leucine formed a uniform coating on the surface of the core particles. The coating stabilised the nanoparticles and prevented the sintering of particles during storage.
Original languageEnglish
Pages (from-to)121-130
JournalJournal of Nanoparticle Research
Issue numberSuppl. 1
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed


  • Aerosol
  • Coating
  • Gas-phase
  • Nanoparticles
  • Pharmaceutical
  • Processing


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