Abstract
Combined gas phase synthesis and coating of sodium chloride (NaCl) and
lactose nanoparticles has been developed using an aerosol flow reactor.
Nano-sized core particles were produced by the droplet-to-particle
method and coated in situ by the physical vapour deposition of L-leucine
vapour. The saturation of L-leucine in the reactor determined the
resulting particle size and size distribution. In general, particle size
increased with the addition of L-leucine and notable narrowing of the
core particle size distribution was observed. In addition, homogeneous
nucleation of the vapour, i.e. formation of pure L-leucine particles,
was observed depending on the saturation conditions of L-leucine as well
as the core particle characteristics. The effects of core particle
properties, i.e. size and solid-state characteristics, on the coating
process were studied by comparing the results for coated NaCl and
lactose particles. During deposition, L-leucine formed a uniform coating
on the surface of the core particles. The coating stabilised the
nanoparticles and prevented the sintering of particles during storage.
Original language | English |
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Pages (from-to) | 121-130 |
Journal | Journal of Nanoparticle Research |
Volume | 10 |
Issue number | Suppl. 1 |
DOIs | |
Publication status | Published - 2008 |
MoE publication type | A1 Journal article-refereed |
Keywords
- Aerosol
- Coating
- Gas-phase
- Nanoparticles
- Pharmaceutical
- Processing