Combined synthesis and in situ coating of nanoparticles in the gas phase

Anna Lähde, Janne Raula, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

Combined gas phase synthesis and coating of sodium chloride (NaCl) and lactose nanoparticles has been developed using an aerosol flow reactor. Nano-sized core particles were produced by the droplet-to-particle method and coated in situ by the physical vapour deposition of L-leucine vapour. The saturation of L-leucine in the reactor determined the resulting particle size and size distribution. In general, particle size increased with the addition of L-leucine and notable narrowing of the core particle size distribution was observed. In addition, homogeneous nucleation of the vapour, i.e. formation of pure L-leucine particles, was observed depending on the saturation conditions of L-leucine as well as the core particle characteristics. The effects of core particle properties, i.e. size and solid-state characteristics, on the coating process were studied by comparing the results for coated NaCl and lactose particles. During deposition, L-leucine formed a uniform coating on the surface of the core particles. The coating stabilised the nanoparticles and prevented the sintering of particles during storage.
Original languageEnglish
Pages (from-to)121-130
JournalJournal of Nanoparticle Research
Volume10
Issue numberSuppl. 1
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Leucine
Coating
Nanoparticles
Gases
leucine
Synthesis
vapor phases
coatings
Coatings
nanoparticles
synthesis
Particle Size
Particle size
Vapors
Lactose
Physical vapor deposition
Reactor
lactose
Sodium chloride
Saturation

Keywords

  • Aerosol
  • Coating
  • Gas-phase
  • Nanoparticles
  • Pharmaceutical
  • Processing

Cite this

Lähde, Anna ; Raula, Janne ; Kauppinen, Esko I. / Combined synthesis and in situ coating of nanoparticles in the gas phase. In: Journal of Nanoparticle Research. 2008 ; Vol. 10, No. Suppl. 1. pp. 121-130.
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abstract = "Combined gas phase synthesis and coating of sodium chloride (NaCl) and lactose nanoparticles has been developed using an aerosol flow reactor. Nano-sized core particles were produced by the droplet-to-particle method and coated in situ by the physical vapour deposition of L-leucine vapour. The saturation of L-leucine in the reactor determined the resulting particle size and size distribution. In general, particle size increased with the addition of L-leucine and notable narrowing of the core particle size distribution was observed. In addition, homogeneous nucleation of the vapour, i.e. formation of pure L-leucine particles, was observed depending on the saturation conditions of L-leucine as well as the core particle characteristics. The effects of core particle properties, i.e. size and solid-state characteristics, on the coating process were studied by comparing the results for coated NaCl and lactose particles. During deposition, L-leucine formed a uniform coating on the surface of the core particles. The coating stabilised the nanoparticles and prevented the sintering of particles during storage.",
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Combined synthesis and in situ coating of nanoparticles in the gas phase. / Lähde, Anna; Raula, Janne; Kauppinen, Esko I. (Corresponding Author).

In: Journal of Nanoparticle Research, Vol. 10, No. Suppl. 1, 2008, p. 121-130.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Combined synthesis and in situ coating of nanoparticles in the gas phase

AU - Lähde, Anna

AU - Raula, Janne

AU - Kauppinen, Esko I.

PY - 2008

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N2 - Combined gas phase synthesis and coating of sodium chloride (NaCl) and lactose nanoparticles has been developed using an aerosol flow reactor. Nano-sized core particles were produced by the droplet-to-particle method and coated in situ by the physical vapour deposition of L-leucine vapour. The saturation of L-leucine in the reactor determined the resulting particle size and size distribution. In general, particle size increased with the addition of L-leucine and notable narrowing of the core particle size distribution was observed. In addition, homogeneous nucleation of the vapour, i.e. formation of pure L-leucine particles, was observed depending on the saturation conditions of L-leucine as well as the core particle characteristics. The effects of core particle properties, i.e. size and solid-state characteristics, on the coating process were studied by comparing the results for coated NaCl and lactose particles. During deposition, L-leucine formed a uniform coating on the surface of the core particles. The coating stabilised the nanoparticles and prevented the sintering of particles during storage.

AB - Combined gas phase synthesis and coating of sodium chloride (NaCl) and lactose nanoparticles has been developed using an aerosol flow reactor. Nano-sized core particles were produced by the droplet-to-particle method and coated in situ by the physical vapour deposition of L-leucine vapour. The saturation of L-leucine in the reactor determined the resulting particle size and size distribution. In general, particle size increased with the addition of L-leucine and notable narrowing of the core particle size distribution was observed. In addition, homogeneous nucleation of the vapour, i.e. formation of pure L-leucine particles, was observed depending on the saturation conditions of L-leucine as well as the core particle characteristics. The effects of core particle properties, i.e. size and solid-state characteristics, on the coating process were studied by comparing the results for coated NaCl and lactose particles. During deposition, L-leucine formed a uniform coating on the surface of the core particles. The coating stabilised the nanoparticles and prevented the sintering of particles during storage.

KW - Aerosol

KW - Coating

KW - Gas-phase

KW - Nanoparticles

KW - Pharmaceutical

KW - Processing

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DO - 10.1007/s11051-008-9399-7

M3 - Article

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JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

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