Commentary: Mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma

Chad M. Thompson, Roland Grafström (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

Occupational exposure to formaldehyde has been linked to nasopharyngeal carcinoma. To date, mechanistic explanations for this association have primarily focused on formaldehyde-induced cytotoxicity, regenerative hyperplasia and DNA damage. However, recent studies broaden the potential mechanisms as it is now well established that formaldehyde dehydrogenase, identical to S-nitrosoglutathione reductase, is an important mediator of cGMP-independent nitric oxide signaling pathways. We have previously described mechanisms by which formaldehyde can influence nitrosothiol homeostasis thereby leading to changes in pulmonary physiology. Considering evidences that nitrosothiols govern the Epstein-Barr virus infection cycle, and that the virus is strongly implicated in the etiology of nasopharyngeal carcinoma, studies are needed to examine the potential for formaldehyde to reactivate the Epstein-Barr virus as well as additively or synergistically interact with the virus to potentiate epithelial cell transformation.
Original languageEnglish
Number of pages6
JournalEnvironmental Health
Volume8
Issue number53
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fingerprint

glutathione-independent formaldehyde dehydrogenase
Formaldehyde
Viruses
Epstein-Barr Virus Infections
Occupational Exposure
Human Herpesvirus 4
DNA Damage
Hyperplasia
Nitric Oxide
Homeostasis
Epithelial Cells
Lung
Formaldehyde poisoning
Nasopharyngeal carcinoma

Keywords

  • formaldehyde
  • formaldehyde exposure
  • carcinomas
  • occupational health
  • occupational safety

Cite this

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abstract = "Occupational exposure to formaldehyde has been linked to nasopharyngeal carcinoma. To date, mechanistic explanations for this association have primarily focused on formaldehyde-induced cytotoxicity, regenerative hyperplasia and DNA damage. However, recent studies broaden the potential mechanisms as it is now well established that formaldehyde dehydrogenase, identical to S-nitrosoglutathione reductase, is an important mediator of cGMP-independent nitric oxide signaling pathways. We have previously described mechanisms by which formaldehyde can influence nitrosothiol homeostasis thereby leading to changes in pulmonary physiology. Considering evidences that nitrosothiols govern the Epstein-Barr virus infection cycle, and that the virus is strongly implicated in the etiology of nasopharyngeal carcinoma, studies are needed to examine the potential for formaldehyde to reactivate the Epstein-Barr virus as well as additively or synergistically interact with the virus to potentiate epithelial cell transformation.",
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Commentary : Mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma. / Thompson, Chad M.; Grafström, Roland (Corresponding Author).

In: Environmental Health, Vol. 8, No. 53, 2009.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

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T2 - Mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma

AU - Thompson, Chad M.

AU - Grafström, Roland

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AB - Occupational exposure to formaldehyde has been linked to nasopharyngeal carcinoma. To date, mechanistic explanations for this association have primarily focused on formaldehyde-induced cytotoxicity, regenerative hyperplasia and DNA damage. However, recent studies broaden the potential mechanisms as it is now well established that formaldehyde dehydrogenase, identical to S-nitrosoglutathione reductase, is an important mediator of cGMP-independent nitric oxide signaling pathways. We have previously described mechanisms by which formaldehyde can influence nitrosothiol homeostasis thereby leading to changes in pulmonary physiology. Considering evidences that nitrosothiols govern the Epstein-Barr virus infection cycle, and that the virus is strongly implicated in the etiology of nasopharyngeal carcinoma, studies are needed to examine the potential for formaldehyde to reactivate the Epstein-Barr virus as well as additively or synergistically interact with the virus to potentiate epithelial cell transformation.

KW - formaldehyde

KW - formaldehyde exposure

KW - carcinomas

KW - occupational health

KW - occupational safety

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