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Comparative characterization of nine novel GH51, GH54 and GH62 α-L-arabinofuranosidases from Penicillium subrubescens

  • Nancy Coconi Linares
  • , Xinxin Li
  • , Adiphol Dilokpimol
  • , Ronald P de Vries*
  • *Corresponding author for this work
  • Utrecht University
  • Westerdijk Fungal Biodiversity Institute

Research output: Contribution to journalArticleScientificpeer-review

Abstract

α-L-Arabinofuranosidases (ABFs) are important enzymes in plant biomass degradation with a wide range of applications. The ascomycete fungus Penicillium subrubescens has more α-L-arabinofuranosidase-encoding genes in its genome compared to other Penicillia. We characterized nine ABFs from Glycoside Hydrolase (GH) families GH51, GH54 and GH62 from this fungus and demonstrated that they have highly diverse specificity and activity levels, indicating that the expansion was accompanied by diversification of the enzymes. Comparison of the substrate preference of the enzymes to the expression of the corresponding genes when the fungus was grown on either of two plant biomass substrates did not show a clear correlation, suggesting a more complex regulatory system governing L-arabinose release from plant biomass by P. subrubescens.

Original languageEnglish
Pages (from-to)360-368
JournalFEBS Letters
Volume596
Issue number3
DOIs
Publication statusPublished - Feb 2022
MoE publication typeA1 Journal article-refereed

Funding

This study was supported by the National Council of Science and Technology of Mexico (CONACyT) for financial support (Grant No. 263888) to NCL. This work was partly supported by the China Scholarship Council (grant no: 201803250066) to XL.

Keywords

  • Penicillium subrubescens
  • arabinoxylan
  • pectin
  • recombinant expression
  • α-l-arabinofuranosidases

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