Abstract
Three treatment planning systems developed for clinical boron neutron capture therapy (BNCT) use are SERA developed by INL/Montana State University, NCTPlan developed by the Harvard-MIT and the CNEA group and JAEA computational dosimetry system (JCDS) developed by Japan Atomic Energy Agency (JAEA) in Japan. Previously, performance of the SERA and NCTPlan has been compared in various studies. In this preliminary study, the dose calculations performed with SERA and JCDS systems were compared in single brain cancer patient case with the FiR 1 epithermal neutron beam. A two-field brain cancer treatment plan was performed with the both codes. The dose components to normal brain, tumor and planning target volume (PTV) were calculated and compared in case of one radiation field and combined two fields. The depth dose distributions and the maximum doses in regions of interest were compared. Calculations with the treatment planning systems for the thermal neutron induced (10B and nitrogen) dose components and photon dose were in good agreement. Higher discrepancy in the fast neutron dose calculations was found. In case of combined two-field treatment plan, overall discrepancy of the maximum weighted dose was ∼3% for normal brain and PTV and ∼4% for tumor dose.
| Original language | English |
|---|---|
| Pages (from-to) | S126-S129 |
| Number of pages | 4 |
| Journal | Applied Radiation and Isotopes |
| Volume | 67 |
| Issue number | 7-8 Supplement |
| DOIs | |
| Publication status | Published - 1 Jul 2009 |
| MoE publication type | A1 Journal article-refereed |
| Event | 13th International Congress on Neutron Capture Therapy BNCT: A new option against cancer - Florence, Italy Duration: 2 Nov 2008 → 8 Nov 2008 |
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Keywords
- Boron neutron capture therapy (BNCT)
- Dose calculation
- JCDS
- MCNP
- SERA
- Treatment planning
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Comparative study of dose calculations with SERA and JCDS treatment planning systems. / Koivunoro, H. (Corresponding Author); Kumada, H.; Seppälä, Tiina; Kotiluoto, Petri; Auterinen, Iiro; Kankaanranta, Leena; Savolainen, S.
In: Applied Radiation and Isotopes, Vol. 67, No. 7-8 Supplement, 01.07.2009, p. S126-S129.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Comparative study of dose calculations with SERA and JCDS treatment planning systems
AU - Koivunoro, H.
AU - Kumada, H.
AU - Seppälä, Tiina
AU - Kotiluoto, Petri
AU - Auterinen, Iiro
AU - Kankaanranta, Leena
AU - Savolainen, S.
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Three treatment planning systems developed for clinical boron neutron capture therapy (BNCT) use are SERA developed by INL/Montana State University, NCTPlan developed by the Harvard-MIT and the CNEA group and JAEA computational dosimetry system (JCDS) developed by Japan Atomic Energy Agency (JAEA) in Japan. Previously, performance of the SERA and NCTPlan has been compared in various studies. In this preliminary study, the dose calculations performed with SERA and JCDS systems were compared in single brain cancer patient case with the FiR 1 epithermal neutron beam. A two-field brain cancer treatment plan was performed with the both codes. The dose components to normal brain, tumor and planning target volume (PTV) were calculated and compared in case of one radiation field and combined two fields. The depth dose distributions and the maximum doses in regions of interest were compared. Calculations with the treatment planning systems for the thermal neutron induced (10B and nitrogen) dose components and photon dose were in good agreement. Higher discrepancy in the fast neutron dose calculations was found. In case of combined two-field treatment plan, overall discrepancy of the maximum weighted dose was ∼3% for normal brain and PTV and ∼4% for tumor dose.
AB - Three treatment planning systems developed for clinical boron neutron capture therapy (BNCT) use are SERA developed by INL/Montana State University, NCTPlan developed by the Harvard-MIT and the CNEA group and JAEA computational dosimetry system (JCDS) developed by Japan Atomic Energy Agency (JAEA) in Japan. Previously, performance of the SERA and NCTPlan has been compared in various studies. In this preliminary study, the dose calculations performed with SERA and JCDS systems were compared in single brain cancer patient case with the FiR 1 epithermal neutron beam. A two-field brain cancer treatment plan was performed with the both codes. The dose components to normal brain, tumor and planning target volume (PTV) were calculated and compared in case of one radiation field and combined two fields. The depth dose distributions and the maximum doses in regions of interest were compared. Calculations with the treatment planning systems for the thermal neutron induced (10B and nitrogen) dose components and photon dose were in good agreement. Higher discrepancy in the fast neutron dose calculations was found. In case of combined two-field treatment plan, overall discrepancy of the maximum weighted dose was ∼3% for normal brain and PTV and ∼4% for tumor dose.
KW - Boron neutron capture therapy (BNCT)
KW - Dose calculation
KW - JCDS
KW - MCNP
KW - SERA
KW - Treatment planning
UR - http://www.scopus.com/inward/record.url?scp=67649400377&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2009.03.092
DO - 10.1016/j.apradiso.2009.03.092
M3 - Article
VL - 67
SP - S126-S129
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 7-8 Supplement
ER -