The recent sequencing efforts have revealed that fungal genomes contain many genes with little or no homology to known genes (20% - 40% of CDS with no hits in Interpro, www.ebi.ac.uk/interpro/index.html). Comparisons to other fungal genomes can add power to the genomic analysis by providing the evolutionary context of genes. Our goal is to compare the protein coding gene contents of fungal genomes and relate the differences to the physiological differences between species and taxonomic groups. However, no single repository currently provides consistent gene annotations of all sequenced fungi. We have produced consistent Interpro annotations and Tribe-MCL (www.ebi.ac.uk/research/cgg/tribe/) clustering of protein coding sequences of 16 sequenced fungal genomes. Our computational system is based on BioPerl (bio.perl.org) scripts, BioSQL schema for storing the sequences and annotations in a relational database and GBrowse (www.gmod.org) genome browser for visualising genomes, genes and gene clusters. By combining these data sources and technology we can carry out comparative genome analysis, offer a local comparative genome browser for experimental biologists and profit from the efforts of BioPerl bioinformatics community.
|Publication status||Published - 2005|
|Event||EUROFUNGBASE Meeting - Sevilla, Spain|
Duration: 16 Nov 2005 → 19 Nov 2005
|Period||16/11/05 → 19/11/05|
Arvas, M., Kivioja, T., Mitchell, A., Saloheimo, M., Oliver, S., & Penttilä, M. (2005). Comparison of protein coding gene content of yeasts and filamentous fungi. EUROFUNGBASE Meeting, Sevilla, Spain.