Concerted diffusion of lipids in raft-like membranes

Touko Apajalahti, Perttu Niemelä, Praveen Nedumpully Govindan, Markus S. Miettinen, Emppu Salonen, Siewert-Jan Marrink, Ilpo Vattulainen (Corresponding Author)

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Abstract

Currently, there is no comprehensive model for the dynamics of cellular membranes. The understanding of even the basic dynamic processes, such as lateral diffusion of lipids, is still quite limited. Recent studies of one-component membrane systems have shown that instead of single-particle motions, the lateral diffusion is driven by a more complex, concerted mechanism for lipid diffusion (E. Falck et al., J. Am. Chem. Soc., 2008, 130, 44–45), where a lipid and its neighbors move in unison in terms of loosely defined clusters. In this work, we extend the previous study by considering the concerted lipid diffusion phenomena in many-component raft-like membranes. This nature of diffusion phenomena emerge in all the cases we have considered, including both atom-scale simulations of lateral diffusion within rafts and coarse-grained MARTINI simulations of diffusion in membranes characterized by coexistence of raft and non-raft domains. The data allows us to identify characteristic time scales for the concerted lipid motions, which turn out to range from hundreds of nanoseconds to several microseconds. Further, we characterize typical length scales associated with the correlated lipid diffusion patterns and find them to be about 10 nm, or even larger if weak correlations are taken into account. Finally, the concerted nature of lipid motions is also found in dissipative particle dynamics simulations of lipid membranes, clarifying the role of hydrodynamics (local momentum conservation) in membrane diffusion phenomena.
Original languageEnglish
Pages (from-to)411-430
JournalFaraday Discussions
Volume144
Issue number1
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

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rafts
lipids
membranes
Membranes
Lipids
simulation
particle motion
Membrane Lipids
conservation
Conservation
Momentum
Hydrodynamics
hydrodynamics
momentum
Atoms

Cite this

Apajalahti, T., Niemelä, P., Govindan, P. N., Miettinen, M. S., Salonen, E., Marrink, S-J., & Vattulainen, I. (2010). Concerted diffusion of lipids in raft-like membranes. Faraday Discussions, 144(1), 411-430. https://doi.org/10.1039/b901487j
Apajalahti, Touko ; Niemelä, Perttu ; Govindan, Praveen Nedumpully ; Miettinen, Markus S. ; Salonen, Emppu ; Marrink, Siewert-Jan ; Vattulainen, Ilpo. / Concerted diffusion of lipids in raft-like membranes. In: Faraday Discussions. 2010 ; Vol. 144, No. 1. pp. 411-430.
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Apajalahti, T, Niemelä, P, Govindan, PN, Miettinen, MS, Salonen, E, Marrink, S-J & Vattulainen, I 2010, 'Concerted diffusion of lipids in raft-like membranes', Faraday Discussions, vol. 144, no. 1, pp. 411-430. https://doi.org/10.1039/b901487j

Concerted diffusion of lipids in raft-like membranes. / Apajalahti, Touko; Niemelä, Perttu; Govindan, Praveen Nedumpully; Miettinen, Markus S.; Salonen, Emppu; Marrink, Siewert-Jan; Vattulainen, Ilpo (Corresponding Author).

In: Faraday Discussions, Vol. 144, No. 1, 2010, p. 411-430.

Research output: Contribution to journalArticleScientificpeer-review

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Apajalahti T, Niemelä P, Govindan PN, Miettinen MS, Salonen E, Marrink S-J et al. Concerted diffusion of lipids in raft-like membranes. Faraday Discussions. 2010;144(1):411-430. https://doi.org/10.1039/b901487j