Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women

Katri Juntunen (Corresponding Author), Witold Mazur, Kirsi Liukkonen, Mariko Uehara, Kaisa Poutanen, Herman Adlercreutz, Hannu Mykkänen

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Rye is an important source of plant lignans in Finland. In the present crossover trial we wanted to study the effect of rye bread as part of the usual diet on serum and urine enterolactone (ENL) concentrations in healthy volunteers. Eighteen men aged 43 (SEM 2·0) YEARS AND TWENTY-ONE WOMEN AGED 43 (sem 1·6) years consumed wholemeal rye bread and white wheat bread in random order for 4 weeks. The bread periods were separated by a 4 week wash-out period. The breads provided at least 20 % of the daily energy intake. The mean intakes of rye bread were 219 (sem 14·6) and 162 (sem 5·3) g/d and those of wheat bread were 200 (sem 9·6) and 153 (sem 5·8) g/d for men and women respectively. Blood samples were collected from all subjects and three 24 h urine samples were collected from ten men and twelve women at the end of both bread periods for the determination of serum concentration and urinary excretion of ENL. The mean serum ENL concentrations in both men and women at the beginning of baseline period and at the end of the rye-bread period remained constant and were significantly higher than those at the end of the wheat-bread period. Correspondingly, daily urinary ENL excretion increased significantly during the rye-bread period compared with the wheat-bread period and was 5- and 10-fold higher in men and women respectively in comparison with the amount of plant lignan precursors measured in the rye bread. These data indicate the presence of other precursors for ENL in rye which are not detected by the current method of measuring plant lignans in food. The possible role of fibre in enhancement of the formation of mammalian lignans from their plant precursors in the gut also remains to be determined.
Original languageEnglish
Pages (from-to)839 - 846
Number of pages8
JournalBritish Journal of Nutrition
Volume84
Issue number6
Publication statusPublished - 2000
MoE publication typeA1 Journal article-refereed

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Bread
Triticum
Serum
Lignans
2,3-bis(3'-hydroxybenzyl)butyrolactone
Secale
Urine
Finland
Energy Intake
Cross-Over Studies
Healthy Volunteers

Keywords

  • Enterolactone
  • Lignans
  • Rye bread
  • Wheat bread
  • Phyto-oestrogens

Cite this

Juntunen, Katri ; Mazur, Witold ; Liukkonen, Kirsi ; Uehara, Mariko ; Poutanen, Kaisa ; Adlercreutz, Herman ; Mykkänen, Hannu. / Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. In: British Journal of Nutrition. 2000 ; Vol. 84, No. 6. pp. 839 - 846.
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abstract = "Rye is an important source of plant lignans in Finland. In the present crossover trial we wanted to study the effect of rye bread as part of the usual diet on serum and urine enterolactone (ENL) concentrations in healthy volunteers. Eighteen men aged 43 (SEM 2·0) YEARS AND TWENTY-ONE WOMEN AGED 43 (sem 1·6) years consumed wholemeal rye bread and white wheat bread in random order for 4 weeks. The bread periods were separated by a 4 week wash-out period. The breads provided at least 20 {\%} of the daily energy intake. The mean intakes of rye bread were 219 (sem 14·6) and 162 (sem 5·3) g/d and those of wheat bread were 200 (sem 9·6) and 153 (sem 5·8) g/d for men and women respectively. Blood samples were collected from all subjects and three 24 h urine samples were collected from ten men and twelve women at the end of both bread periods for the determination of serum concentration and urinary excretion of ENL. The mean serum ENL concentrations in both men and women at the beginning of baseline period and at the end of the rye-bread period remained constant and were significantly higher than those at the end of the wheat-bread period. Correspondingly, daily urinary ENL excretion increased significantly during the rye-bread period compared with the wheat-bread period and was 5- and 10-fold higher in men and women respectively in comparison with the amount of plant lignan precursors measured in the rye bread. These data indicate the presence of other precursors for ENL in rye which are not detected by the current method of measuring plant lignans in food. The possible role of fibre in enhancement of the formation of mammalian lignans from their plant precursors in the gut also remains to be determined.",
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Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. / Juntunen, Katri (Corresponding Author); Mazur, Witold; Liukkonen, Kirsi; Uehara, Mariko; Poutanen, Kaisa; Adlercreutz, Herman; Mykkänen, Hannu.

In: British Journal of Nutrition, Vol. 84, No. 6, 2000, p. 839 - 846.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women

AU - Juntunen, Katri

AU - Mazur, Witold

AU - Liukkonen, Kirsi

AU - Uehara, Mariko

AU - Poutanen, Kaisa

AU - Adlercreutz, Herman

AU - Mykkänen, Hannu

PY - 2000

Y1 - 2000

N2 - Rye is an important source of plant lignans in Finland. In the present crossover trial we wanted to study the effect of rye bread as part of the usual diet on serum and urine enterolactone (ENL) concentrations in healthy volunteers. Eighteen men aged 43 (SEM 2·0) YEARS AND TWENTY-ONE WOMEN AGED 43 (sem 1·6) years consumed wholemeal rye bread and white wheat bread in random order for 4 weeks. The bread periods were separated by a 4 week wash-out period. The breads provided at least 20 % of the daily energy intake. The mean intakes of rye bread were 219 (sem 14·6) and 162 (sem 5·3) g/d and those of wheat bread were 200 (sem 9·6) and 153 (sem 5·8) g/d for men and women respectively. Blood samples were collected from all subjects and three 24 h urine samples were collected from ten men and twelve women at the end of both bread periods for the determination of serum concentration and urinary excretion of ENL. The mean serum ENL concentrations in both men and women at the beginning of baseline period and at the end of the rye-bread period remained constant and were significantly higher than those at the end of the wheat-bread period. Correspondingly, daily urinary ENL excretion increased significantly during the rye-bread period compared with the wheat-bread period and was 5- and 10-fold higher in men and women respectively in comparison with the amount of plant lignan precursors measured in the rye bread. These data indicate the presence of other precursors for ENL in rye which are not detected by the current method of measuring plant lignans in food. The possible role of fibre in enhancement of the formation of mammalian lignans from their plant precursors in the gut also remains to be determined.

AB - Rye is an important source of plant lignans in Finland. In the present crossover trial we wanted to study the effect of rye bread as part of the usual diet on serum and urine enterolactone (ENL) concentrations in healthy volunteers. Eighteen men aged 43 (SEM 2·0) YEARS AND TWENTY-ONE WOMEN AGED 43 (sem 1·6) years consumed wholemeal rye bread and white wheat bread in random order for 4 weeks. The bread periods were separated by a 4 week wash-out period. The breads provided at least 20 % of the daily energy intake. The mean intakes of rye bread were 219 (sem 14·6) and 162 (sem 5·3) g/d and those of wheat bread were 200 (sem 9·6) and 153 (sem 5·8) g/d for men and women respectively. Blood samples were collected from all subjects and three 24 h urine samples were collected from ten men and twelve women at the end of both bread periods for the determination of serum concentration and urinary excretion of ENL. The mean serum ENL concentrations in both men and women at the beginning of baseline period and at the end of the rye-bread period remained constant and were significantly higher than those at the end of the wheat-bread period. Correspondingly, daily urinary ENL excretion increased significantly during the rye-bread period compared with the wheat-bread period and was 5- and 10-fold higher in men and women respectively in comparison with the amount of plant lignan precursors measured in the rye bread. These data indicate the presence of other precursors for ENL in rye which are not detected by the current method of measuring plant lignans in food. The possible role of fibre in enhancement of the formation of mammalian lignans from their plant precursors in the gut also remains to be determined.

KW - Enterolactone

KW - Lignans

KW - Rye bread

KW - Wheat bread

KW - Phyto-oestrogens

UR - https://doi.org/10.1017/S0007114500002452

M3 - Article

VL - 84

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EP - 846

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

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ER -