Contributions of biotechnology to the production of mannitol

K. Kiviharju, Antti Nyyssölä

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Mannitol is a 6-carbon sugar alcohol that has been produced traditionally by chemical catalysis. Biotechnology has brought advances to the production in terms of substrate purity, process equipment requirements and safety. Enzymatic methods have improved the yields and the use of microbes has brought versatility to the range of substrates that can be used in the processes. Some of the microbial processes are already industrially feasible and could be taken to further use. The most promising production strategy reported so far has been the utilization of non-growing cells of heterofermentative lactic acid bacteria for converting fructose to mannitol. The latest developments in the field have dealt with the use of recombinant strains in mannitol production.
Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalRecent Patents on Biotechnology
Volume2
Issue number2
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Mannitol
Biotechnology
Equipment Safety
Sugar Alcohols
Fructose
Substrates
Lactic acid
Catalysis
Lactic Acid
Bacteria
Carbon

Keywords

  • Enzymatic
  • Growing cells
  • Immobilization
  • Mannitol
  • Resting cells

Cite this

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Contributions of biotechnology to the production of mannitol. / Kiviharju, K.; Nyyssölä, Antti.

In: Recent Patents on Biotechnology, Vol. 2, No. 2, 2008, p. 73-78.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Kiviharju, K.

AU - Nyyssölä, Antti

PY - 2008

Y1 - 2008

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AB - Mannitol is a 6-carbon sugar alcohol that has been produced traditionally by chemical catalysis. Biotechnology has brought advances to the production in terms of substrate purity, process equipment requirements and safety. Enzymatic methods have improved the yields and the use of microbes has brought versatility to the range of substrates that can be used in the processes. Some of the microbial processes are already industrially feasible and could be taken to further use. The most promising production strategy reported so far has been the utilization of non-growing cells of heterofermentative lactic acid bacteria for converting fructose to mannitol. The latest developments in the field have dealt with the use of recombinant strains in mannitol production.

KW - Enzymatic

KW - Growing cells

KW - Immobilization

KW - Mannitol

KW - Resting cells

U2 - 10.2174/187220808784619702

DO - 10.2174/187220808784619702

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JO - Recent Patents on Biotechnology

JF - Recent Patents on Biotechnology

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