Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases

Wenshu He; Can Baysal; Maria Lobato Gómez; Xin Huang; Derry Alvarez; Changfu Zhu; Victoria Armario-Najera; Aamaya Blanco Perera; Pedro Cerda Bennaser; Andrea Saba-Mayoral; Guillermo Sobrino-Mengual; Ashwin Vargheese; Rita Abranches; Isabel Alexandra Abreu; Shanmugaraj Balamurugan; Ralph Bock; Johannes F. Buyel; Nicolau B. da Cunha; Henry Daniell; Roland Faller; André Folgado; Iyappan Gowtham; Suvi T. Häkkinen; Shashi Kumar; Ramalingam Sathish Kumar; Cristiano Lacorte; George P. Lomonossoff; Ines M. Luís; Julian K.-C. Ma; Karen A. McDonald; Andre Murad; Somen Nandi; Barry O’Keef; Subramanian Parthiban; Mathew J. Paul; Daniel Ponndorf; Elibio Rech; Julio C.M. Rodrigues; Stephanie Ruf; Stefan Schillberg; Jennifer Schwestka; Priya S. Shah; Rahul Singh; Eva Stoger; Richard M. Twyman; Inchakalody P. Varghese; Giovanni R. Vianna; Gina Webster; Ruud H.P. Wilbers; Paul Christou; Kirsi Marja Oksman-Caldentey; Teresa Capell

doi:10.1111/pbi.13658

Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases

Wenshu He, Can Baysal, Maria Lobato Gómez, Xin Huang, Derry Alvarez, Changfu Zhu, Victoria Armario-Najera, Aamaya Blanco Perera, Pedro Cerda Bennaser, Andrea Saba-Mayoral, Guillermo Sobrino-Mengual, Ashwin Vargheese, Rita Abranches, Isabel Alexandra Abreu, Shanmugaraj Balamurugan, Ralph Bock, Johannes F. Buyel, Nicolau B. da Cunha, Henry Daniell, Roland FallerAndré Folgado, Iyappan Gowtham, Suvi T. Häkkinen, Shashi Kumar, Ramalingam Sathish Kumar, Cristiano Lacorte, George P. Lomonossoff, Ines M. Luís, Julian K.-C. Ma, Karen A. McDonald, Andre Murad, Somen Nandi, Barry O’Keef, Subramanian Parthiban, Mathew J. Paul, Daniel Ponndorf, Elibio Rech, Julio C.M. Rodrigues, Stephanie Ruf, Stefan Schillberg, Jennifer Schwestka, Priya S. Shah, Rahul Singh, Eva Stoger, Richard M. Twyman, Inchakalody P. Varghese, Giovanni R. Vianna, Gina Webster, Ruud H.P. Wilbers, Paul Christou, Kirsi Marja Oksman-Caldentey^*, Teresa Capell^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article › peer-review

35 Citations (Scopus)

Abstract

The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.

Original language	English
Pages (from-to)	1921-1936
Number of pages	16
Journal	Plant Biotechnology Journal
Volume	19
Issue number	10
Early online date	28 Jun 2021
DOIs	https://doi.org/10.1111/pbi.13658
Publication status	Published - Oct 2021
MoE publication type	A2 Review article in a scientific journal

Funding

The authors would like to thank the Spanish Ministry of Economy, Industry and Competitiveness (project AGL2017-85377-R), the Spanish Ministry of Science, Innovation and Universities (projects RTI2018-097613-B-I00 and PGC2018-097655-B-I00), the EU Horizon 2020 project Pharma-Factory (774078) and the Generalitat de Catalunya (Grups Consolidats2017‐SGR828); Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), Departament d'Empresa i Coneixement de la Generalitat de Catalunya (PANDÈMIES 2020); Project LISBOA-01-0145-FEDER-007660 (Microbiologia Molecular, Estrutural e Celular funded by FEDER funds through COMPETE2020)—Programa Operacional Competitividade e Internacionalização (POCI) and by the FCT (Portugal) through the R&D Unit, UIDB/04551/2020 (GREEN-IT—Bioresources for Sustainability); UKIERI and the Hotung Foundation for sustained support of the Bharathiar University/St. George’s Univ. of London collaboration and the Molecular Immunology Unit at St. George’s Univ. of London. The Max Planck Society, the EU Horizon 2020 project Newcotiana (760331-2) and a grant from the European Research Council (ERC-ADG-2014; grant agreement 669982) to RB. KMOC, RMT and STH acknowledge support from the InnCoCells project funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement 101000373. PSS, KAM, RF and SN are partially supported by a CRAFT award (COVID-19 Research Accelerator Funding Track) by the University of California Davis. KAM and SN were partially supported by NASA Space Technology Research (award number NNX17AJ31G) and by the Translational Research Institute through NASA (grant number NNX16AO69A); EMBRAPA (Brazilian Agricultural Corporation), INCT BioSyn (National Institute of Science and Technology in Synthetic Biology), CNPq, CAPES, Brazilian Ministry of Health, FAPDFnd Universidade Católica de Brasília (UCB), Brasília, Brazil; BBSRC Grant BB/L020955/1, the JIC Strategic Programme Grant ‘Molecules from Nature – Enhanced Research Capacity’ (BBS/E/J/000PR9794), the John Innes Foundation and the Department of Health and Social Care using UK Aid funding managed by the BBSRC; and The Austrian Science Fund FWF (project W1224). TTW Veni Grant 16740 from the Netherlands Organization for Scientific Research. Research in the Daniell laboratory was supported by NIH grants R01 GM 63879, R01 107904, R01 HL 109442, R01 133191 and grants from Bayer, Novo Nordisk and Shire/Takeda. The National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, through the Science Moving TowArds Research Translation and Therapy (SMARTT) programme contracts # HHSN268201600014C, HHSN268201600011C supported IND enabling regulatory, toxicology and pharmacokinetic studies.

Keywords

endemic disease
molecular farming
oral delivery
plant-made pharmaceuticals
re-emerging disease
Animals
Artemisia annua
Humans
Plants, Edible
Molecular Farming
Pharmaceutical Preparations
Communicable Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/pbi.13658Licence: CC BY

Cite this

He, W., Baysal, C., Lobato Gómez, M., Huang, X., Alvarez, D., Zhu, C., Armario-Najera, V., Blanco Perera, A., Cerda Bennaser, P., Saba-Mayoral, A., Sobrino-Mengual, G., Vargheese, A., Abranches, R., Alexandra Abreu, I., Balamurugan, S., Bock, R., Buyel, J. F., da Cunha, N. B., Daniell, H., ... Capell, T. (2021). Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases. Plant Biotechnology Journal, 19(10), 1921-1936. https://doi.org/10.1111/pbi.13658

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title = "Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases",

abstract = "The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.",

keywords = "endemic disease, molecular farming, oral delivery, plant-made pharmaceuticals, re-emerging disease, Animals, Artemisia annua, Humans, Plants, Edible, Molecular Farming, Pharmaceutical Preparations, Communicable Diseases",

author = "Wenshu He and Can Baysal and {Lobato G{\'o}mez}, Maria and Xin Huang and Derry Alvarez and Changfu Zhu and Victoria Armario-Najera and {Blanco Perera}, Aamaya and {Cerda Bennaser}, Pedro and Andrea Saba-Mayoral and Guillermo Sobrino-Mengual and Ashwin Vargheese and Rita Abranches and {Alexandra Abreu}, Isabel and Shanmugaraj Balamurugan and Ralph Bock and Buyel, {Johannes F.} and {da Cunha}, {Nicolau B.} and Henry Daniell and Roland Faller and Andr{\'e} Folgado and Iyappan Gowtham and H{\"a}kkinen, {Suvi T.} and Shashi Kumar and {Sathish Kumar}, Ramalingam and Cristiano Lacorte and Lomonossoff, {George P.} and Lu{\'i}s, {Ines M.} and {K.-C. Ma}, Julian and McDonald, {Karen A.} and Andre Murad and Somen Nandi and Barry O{\textquoteright}Keef and Subramanian Parthiban and Paul, {Mathew J.} and Daniel Ponndorf and Elibio Rech and Rodrigues, {Julio C.M.} and Stephanie Ruf and Stefan Schillberg and Jennifer Schwestka and Shah, {Priya S.} and Rahul Singh and Eva Stoger and Twyman, {Richard M.} and Varghese, {Inchakalody P.} and Vianna, {Giovanni R.} and Gina Webster and Wilbers, {Ruud H.P.} and Paul Christou and Oksman-Caldentey, {Kirsi Marja} and Teresa Capell",

note = "{\textcopyright} 2021 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.",

year = "2021",

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language = "English",

volume = "19",

pages = "1921--1936",

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He, W, Baysal, C, Lobato Gómez, M, Huang, X, Alvarez, D, Zhu, C, Armario-Najera, V, Blanco Perera, A, Cerda Bennaser, P, Saba-Mayoral, A, Sobrino-Mengual, G, Vargheese, A, Abranches, R, Alexandra Abreu, I, Balamurugan, S, Bock, R, Buyel, JF, da Cunha, NB, Daniell, H, Faller, R, Folgado, A, Gowtham, I, Häkkinen, ST, Kumar, S, Sathish Kumar, R, Lacorte, C, Lomonossoff, GP, Luís, IM, K.-C. Ma, J, McDonald, KA, Murad, A, Nandi, S, O’Keef, B, Parthiban, S, Paul, MJ, Ponndorf, D, Rech, E, Rodrigues, JCM, Ruf, S, Schillberg, S, Schwestka, J, Shah, PS, Singh, R, Stoger, E, Twyman, RM, Varghese, IP, Vianna, GR, Webster, G, Wilbers, RHP, Christou, P, Oksman-Caldentey, KM & Capell, T 2021, 'Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases', Plant Biotechnology Journal, vol. 19, no. 10, pp. 1921-1936. https://doi.org/10.1111/pbi.13658

Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases. / He, Wenshu; Baysal, Can; Lobato Gómez, Maria et al.
In: Plant Biotechnology Journal, Vol. 19, No. 10, 10.2021, p. 1921-1936.

Research output: Contribution to journal › Review Article › peer-review

TY - JOUR

T1 - Contributions of the international plant science community to the fight against infectious diseases in humans—part 2

T2 - Affordable drugs in edible plants for endemic and re-emerging diseases

AU - He, Wenshu

AU - Baysal, Can

AU - Lobato Gómez, Maria

AU - Huang, Xin

AU - Alvarez, Derry

AU - Zhu, Changfu

AU - Armario-Najera, Victoria

AU - Blanco Perera, Aamaya

AU - Cerda Bennaser, Pedro

AU - Saba-Mayoral, Andrea

AU - Sobrino-Mengual, Guillermo

AU - Vargheese, Ashwin

AU - Abranches, Rita

AU - Alexandra Abreu, Isabel

AU - Balamurugan, Shanmugaraj

AU - Bock, Ralph

AU - Buyel, Johannes F.

AU - da Cunha, Nicolau B.

AU - Daniell, Henry

AU - Faller, Roland

AU - Folgado, André

AU - Gowtham, Iyappan

AU - Häkkinen, Suvi T.

AU - Kumar, Shashi

AU - Sathish Kumar, Ramalingam

AU - Lacorte, Cristiano

AU - Lomonossoff, George P.

AU - Luís, Ines M.

AU - K.-C. Ma, Julian

AU - McDonald, Karen A.

AU - Murad, Andre

AU - Nandi, Somen

AU - O’Keef, Barry

AU - Parthiban, Subramanian

AU - Paul, Mathew J.

AU - Ponndorf, Daniel

AU - Rech, Elibio

AU - Rodrigues, Julio C.M.

AU - Ruf, Stephanie

AU - Schillberg, Stefan

AU - Schwestka, Jennifer

AU - Shah, Priya S.

AU - Singh, Rahul

AU - Stoger, Eva

AU - Twyman, Richard M.

AU - Varghese, Inchakalody P.

AU - Vianna, Giovanni R.

AU - Webster, Gina

AU - Wilbers, Ruud H.P.

AU - Christou, Paul

AU - Oksman-Caldentey, Kirsi Marja

AU - Capell, Teresa

PY - 2021/10

Y1 - 2021/10

N2 - The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.

AB - The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.

KW - endemic disease

KW - molecular farming

KW - oral delivery

KW - plant-made pharmaceuticals

KW - re-emerging disease

KW - Animals

KW - Artemisia annua

KW - Humans

KW - Plants, Edible

KW - Molecular Farming

KW - Pharmaceutical Preparations

KW - Communicable Diseases

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DO - 10.1111/pbi.13658

M3 - Review Article

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SN - 1467-7644

VL - 19

SP - 1921

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JO - Plant Biotechnology Journal

JF - Plant Biotechnology Journal

IS - 10

ER -

Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases

Abstract

Funding

Keywords

UN SDGs

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InnCoCells: Innovative high-value cosmetic products from plants and plant cells

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Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re-emerging diseases

Abstract

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

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InnCoCells: Innovative high-value cosmetic products from plants and plant cells

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