Controlled diazonium electrodeposition towards a biosensor for C-reactive protein

Liam Gillan (Corresponding Author), Tuija Teerinen, Leena-Sisko Johansson, Maria Smolander

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)


Electrografting of aryldiazonium species is useful for linkage between electrochemical transducer surface and biosensor recognition elements. However, the process proceeds uncontrollably to form branched/multilayer growth. This paper reports harnessing steric hindrance for controlled growth of aryldiazonium coupling agent during electrografting to screen-printed carbon electrode surface, which was subsequently used for linkage of CRP recognition elements to form a biosensor with greater sensitivity (32.0 ± 0.5 μA/(ng/mL) than that formed by way of uncontrolled growth (26.6. ± 5.3 μA/(ng/mL) across a highly sensitive operating range of 0.01–10 ng/mL. To the best of our knowledge, this is the first report of this approach demonstrated as a route for biosensor fabrication. This finding suggests the approach can be exploited in immunosensor assays.

Original languageEnglish
Article number100060
JournalSensors International
Publication statusPublished - 2021
MoE publication typeA1 Journal article-refereed


  • Aryldiazonium grafting
  • Aryldiazonium salt
  • C-reactive protein
  • Electrochemical biosensor


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