Corn starches as film formers in aqueous-based film coating

Päivi Palviainen, Jyrki Heinämäki, Päivi Myllärinen, Pirkko Forssell, Jouko Yliruusi, Riitta Partanen

Research output: Contribution to journalArticleScientificpeer-review

48 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.
Original languageEnglish
Pages (from-to)353-361
JournalPharmaceutical Development and Technology
Volume6
Issue number3
DOIs
Publication statusPublished - 2001
MoE publication typeA1 Journal article-refereed

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    Palviainen, P., Heinämäki, J., Myllärinen, P., Forssell, P., Yliruusi, J., & Partanen, R. (2001). Corn starches as film formers in aqueous-based film coating. Pharmaceutical Development and Technology, 6(3), 353-361. https://doi.org/10.1081/PDT-100002617