Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 353-361 |
| Journal | Pharmaceutical Development and Technology |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 |
| MoE publication type | A1 Journal article-refereed |
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Corn starches as film formers in aqueous-based film coating. / Palviainen, Päivi; Heinämäki, Jyrki; Myllärinen, Päivi; Forssell, Pirkko; Yliruusi, Jouko; Partanen, Riitta.
In: Pharmaceutical Development and Technology, Vol. 6, No. 3, 2001, p. 353-361.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Corn starches as film formers in aqueous-based film coating
AU - Palviainen, Päivi
AU - Heinämäki, Jyrki
AU - Myllärinen, Päivi
AU - Forssell, Pirkko
AU - Yliruusi, Jouko
AU - Partanen, Riitta
PY - 2001
Y1 - 2001
N2 - The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.
AB - The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.
U2 - 10.1081/PDT-100002617
DO - 10.1081/PDT-100002617
M3 - Article
VL - 6
SP - 353
EP - 361
JO - Pharmaceutical Development and Technology
JF - Pharmaceutical Development and Technology
SN - 1083-7450
IS - 3
ER -