Corn starches as film formers in aqueous-based film coating

P. Palviainen, J. Heinämäki, Päivi Myllärinen, Pirkko Forssell, J. Yliruusi, Riitta Partanen

Research output: Contribution to journalArticleScientificpeer-review

46 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.
Original languageEnglish
Pages (from-to)353-361
Number of pages9
JournalPharmaceutical Development and Technology
Volume6
Issue number3
DOIs
Publication statusPublished - 2001
MoE publication typeA1 Journal article-refereed

Fingerprint

Starch
Zea mays
Tablets
Plasticizers
Amylose
Sorbitol
Tensile Strength
Glycerol
Weight Gain
Suspensions
Air

Cite this

Palviainen, P., Heinämäki, J., Myllärinen, P., Forssell, P., Yliruusi, J., & Partanen, R. (2001). Corn starches as film formers in aqueous-based film coating. Pharmaceutical Development and Technology, 6(3), 353-361. https://doi.org/10.1081/PDT-100002617
Palviainen, P. ; Heinämäki, J. ; Myllärinen, Päivi ; Forssell, Pirkko ; Yliruusi, J. ; Partanen, Riitta. / Corn starches as film formers in aqueous-based film coating. In: Pharmaceutical Development and Technology. 2001 ; Vol. 6, No. 3. pp. 353-361.
@article{269209732c7e4349932c037eed7f2c90,
title = "Corn starches as film formers in aqueous-based film coating",
abstract = "The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5{\%} for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1{\%}) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.",
author = "P. Palviainen and J. Hein{\"a}m{\"a}ki and P{\"a}ivi Myll{\"a}rinen and Pirkko Forssell and J. Yliruusi and Riitta Partanen",
year = "2001",
doi = "10.1081/PDT-100002617",
language = "English",
volume = "6",
pages = "353--361",
journal = "Pharmaceutical Development and Technology",
issn = "1083-7450",
publisher = "Informa Healthcare",
number = "3",

}

Palviainen, P, Heinämäki, J, Myllärinen, P, Forssell, P, Yliruusi, J & Partanen, R 2001, 'Corn starches as film formers in aqueous-based film coating', Pharmaceutical Development and Technology, vol. 6, no. 3, pp. 353-361. https://doi.org/10.1081/PDT-100002617

Corn starches as film formers in aqueous-based film coating. / Palviainen, P.; Heinämäki, J.; Myllärinen, Päivi; Forssell, Pirkko; Yliruusi, J.; Partanen, Riitta.

In: Pharmaceutical Development and Technology, Vol. 6, No. 3, 2001, p. 353-361.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Corn starches as film formers in aqueous-based film coating

AU - Palviainen, P.

AU - Heinämäki, J.

AU - Myllärinen, Päivi

AU - Forssell, Pirkko

AU - Yliruusi, J.

AU - Partanen, Riitta

PY - 2001

Y1 - 2001

N2 - The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.

AB - The purpose of this study was to evaluate the film formation ability and mechanical stress–strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.

U2 - 10.1081/PDT-100002617

DO - 10.1081/PDT-100002617

M3 - Article

VL - 6

SP - 353

EP - 361

JO - Pharmaceutical Development and Technology

JF - Pharmaceutical Development and Technology

SN - 1083-7450

IS - 3

ER -

Palviainen P, Heinämäki J, Myllärinen P, Forssell P, Yliruusi J, Partanen R. Corn starches as film formers in aqueous-based film coating. Pharmaceutical Development and Technology. 2001;6(3):353-361. https://doi.org/10.1081/PDT-100002617