Correlation between symptoms and functioning in psychiatric patients and temporal patterns of medication refills derived from pharmacy prescription claims

Miikka Ermes, Anna Leena Vuorinen, Geoffrey Schrader, Niranjan Bidargaddi (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objectives: Pharmacy dispensing claims data provide longitudinal records of prescriptions and refill events. Previous studies in psychiatric patients have utilised these data to derive indicators of medication adherence based on information regarding the amount of medication supplied and its dosage. An alternative approach was developed in which the regularity of medication refill events was analysed as a potential indicator of psychiatric patient symptoms and functioning. Methods: A method to quantify the regularity of medication refills was developed and subsequently used to investigate how the resulting regularity index (RI), derived from retrospective prescription refill records, correlated with symptomatic and functional assessments of 89 psychiatric patients after adjusting for covariates. Results: A two-step hierarchical regression model indicated that variances explained by prior hospitalisation and the RI were significant for patient scores on the Kessler 10 Psychological Distress Scale (K10), standard beta value 0.22, p < 0.05, for the SF-12 MC, standard beta value −0.31, p < 0.01, and the Work and Social Adjustment Scale (WSAS), standard beta value 0.31, p < 0.01. Conclusions: This method to quantify the regularity of medication refills using prescription supply date alone may provide valuable information about patients’ symptoms and functioning.

Original languageEnglish
Pages (from-to)643-647
Number of pages5
JournalAustralasian Psychiatry
Volume26
Issue number6
DOIs
Publication statusPublished - 1 Dec 2018
MoE publication typeNot Eligible

Fingerprint

Prescriptions
Psychiatry
Social Adjustment
Medication Adherence
Hospitalization
Psychology

Keywords

  • clinical status
  • electronic prescription claims
  • medication adherence

Cite this

@article{5b85368751984e3bba8653e81197f4aa,
title = "Correlation between symptoms and functioning in psychiatric patients and temporal patterns of medication refills derived from pharmacy prescription claims",
abstract = "Objectives: Pharmacy dispensing claims data provide longitudinal records of prescriptions and refill events. Previous studies in psychiatric patients have utilised these data to derive indicators of medication adherence based on information regarding the amount of medication supplied and its dosage. An alternative approach was developed in which the regularity of medication refill events was analysed as a potential indicator of psychiatric patient symptoms and functioning. Methods: A method to quantify the regularity of medication refills was developed and subsequently used to investigate how the resulting regularity index (RI), derived from retrospective prescription refill records, correlated with symptomatic and functional assessments of 89 psychiatric patients after adjusting for covariates. Results: A two-step hierarchical regression model indicated that variances explained by prior hospitalisation and the RI were significant for patient scores on the Kessler 10 Psychological Distress Scale (K10), standard beta value 0.22, p < 0.05, for the SF-12 MC, standard beta value −0.31, p < 0.01, and the Work and Social Adjustment Scale (WSAS), standard beta value 0.31, p < 0.01. Conclusions: This method to quantify the regularity of medication refills using prescription supply date alone may provide valuable information about patients’ symptoms and functioning.",
keywords = "clinical status, electronic prescription claims, medication adherence",
author = "Miikka Ermes and Vuorinen, {Anna Leena} and Geoffrey Schrader and Niranjan Bidargaddi",
year = "2018",
month = "12",
day = "1",
doi = "10.1177/1039856218781019",
language = "English",
volume = "26",
pages = "643--647",
journal = "Australasian Psychiatry",
issn = "1039-8562",
publisher = "SAGE Publications",
number = "6",

}

Correlation between symptoms and functioning in psychiatric patients and temporal patterns of medication refills derived from pharmacy prescription claims. / Ermes, Miikka; Vuorinen, Anna Leena; Schrader, Geoffrey; Bidargaddi, Niranjan (Corresponding Author).

In: Australasian Psychiatry, Vol. 26, No. 6, 01.12.2018, p. 643-647.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Correlation between symptoms and functioning in psychiatric patients and temporal patterns of medication refills derived from pharmacy prescription claims

AU - Ermes, Miikka

AU - Vuorinen, Anna Leena

AU - Schrader, Geoffrey

AU - Bidargaddi, Niranjan

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objectives: Pharmacy dispensing claims data provide longitudinal records of prescriptions and refill events. Previous studies in psychiatric patients have utilised these data to derive indicators of medication adherence based on information regarding the amount of medication supplied and its dosage. An alternative approach was developed in which the regularity of medication refill events was analysed as a potential indicator of psychiatric patient symptoms and functioning. Methods: A method to quantify the regularity of medication refills was developed and subsequently used to investigate how the resulting regularity index (RI), derived from retrospective prescription refill records, correlated with symptomatic and functional assessments of 89 psychiatric patients after adjusting for covariates. Results: A two-step hierarchical regression model indicated that variances explained by prior hospitalisation and the RI were significant for patient scores on the Kessler 10 Psychological Distress Scale (K10), standard beta value 0.22, p < 0.05, for the SF-12 MC, standard beta value −0.31, p < 0.01, and the Work and Social Adjustment Scale (WSAS), standard beta value 0.31, p < 0.01. Conclusions: This method to quantify the regularity of medication refills using prescription supply date alone may provide valuable information about patients’ symptoms and functioning.

AB - Objectives: Pharmacy dispensing claims data provide longitudinal records of prescriptions and refill events. Previous studies in psychiatric patients have utilised these data to derive indicators of medication adherence based on information regarding the amount of medication supplied and its dosage. An alternative approach was developed in which the regularity of medication refill events was analysed as a potential indicator of psychiatric patient symptoms and functioning. Methods: A method to quantify the regularity of medication refills was developed and subsequently used to investigate how the resulting regularity index (RI), derived from retrospective prescription refill records, correlated with symptomatic and functional assessments of 89 psychiatric patients after adjusting for covariates. Results: A two-step hierarchical regression model indicated that variances explained by prior hospitalisation and the RI were significant for patient scores on the Kessler 10 Psychological Distress Scale (K10), standard beta value 0.22, p < 0.05, for the SF-12 MC, standard beta value −0.31, p < 0.01, and the Work and Social Adjustment Scale (WSAS), standard beta value 0.31, p < 0.01. Conclusions: This method to quantify the regularity of medication refills using prescription supply date alone may provide valuable information about patients’ symptoms and functioning.

KW - clinical status

KW - electronic prescription claims

KW - medication adherence

UR - http://www.scopus.com/inward/record.url?scp=85049790447&partnerID=8YFLogxK

U2 - 10.1177/1039856218781019

DO - 10.1177/1039856218781019

M3 - Article

AN - SCOPUS:85049790447

VL - 26

SP - 643

EP - 647

JO - Australasian Psychiatry

JF - Australasian Psychiatry

SN - 1039-8562

IS - 6

ER -