Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients

Outi Kilpivaara, Jirina Bartkova, Hannaleena Eerola, Kirsi Syrjäkoski, Pia Vahteristo, Jiri Lukas, Carl Blomqvist, Kaija Holli, Päivi Heikkilä, Guido Sauter, Olli Kallioniemi, Jiri Bartek, Heli Nevanlinna (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    86 Citations (Scopus)

    Abstract

    The CHEK2 kinase is a tumor suppressor whose activation in response to DNA double‐strand breaks contributes to cell cycle arrest or apoptosis. The c.1100delC mutation is associated with familial breast cancer, and tumors from mutation carriers show reduced or absent CHEK2 protein expression. We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency). CHEK2 protein expression was reduced in 21.1% of the unselected breast cancers studied. Tumors with reduced CHEK2 expression had more often larger primary tumor size (pT3–4; nominal significance p = 0.002) compared to tumors with normal staining. A similar trend for larger tumor size was seen among the 37 breast tumors from c.1100delC germ line mutation carriers. Tumors from c.1100delC mutation carriers were of higher grade than those of noncarriers (nominal significance p = 0.02). The c.1100delC germ line mutation also associated strongly with bilateral breast cancer. No significant correlation was seen between CHEK2 status and hormone receptor status, histology, lymph node status, or overall survival.
    Original languageEnglish
    Pages (from-to)575 - 580
    Number of pages6
    JournalInternational Journal of Cancer
    Volume113
    Issue number4
    DOIs
    Publication statusPublished - 2005
    MoE publication typeA1 Journal article-refereed

    Keywords

    • CHEK2
    • tumor characteristics
    • breast cancer

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