Cromolycate induces a rebound effect on blood/milk permeability in subclinical mastitis

Satu Pyörälä (Corresponding Author), Tiina Mattila, Markus Sandholm

Research output: Contribution to journalArticleScientificpeer-review


Chronic subclinical mastitis represents a vicious cycle of constant tissue irritation by bacteria and inflammatory response of the host. Antibiotics have proven relatively inefficient in eliminating chronic mastitic infections. The use of anti-inflammatory agents in mastitis is controversial. Theoretically, the inflammation should not be suppressed as this is a host defence mechanism of the body. However, because it is uncertain whether the infection or chronic inflammation causes more harm to the tissue, there have been efforts to use anti-inflammatory agents such as glucocorticoids and antipyretic analgetics. The problem is that there is insufficient evidence as to which inflammatory mediators (histamine, kinins, prostaglandins, leukotrienes, PAF, interleukin-1 etc.) alone or in combination are important in mastitis.
Original languageEnglish
Pages (from-to)139-141
JournalActa Veterinaria Scandinavica
Issue number1
Publication statusPublished - 1988
MoE publication typeA1 Journal article-refereed


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