Crosslinking of agar by diisocyanates

A.K. Sonker, M. Belay, K. Rathore, K. Jahan, S. Verma, G. Ramanathan, V. Verma (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)


In the present study, crosslinking of agar using diisocyanate (DI) was demonstrated to limit the high water absorption property of agar. In addition, the efficacy of aromatic diisocyanate, DDI (4, 4 diphenyl diisocyanate) and aliphatic diisocyanate, HDI (1, 6 hexamethylene diisocyanate) on crosslinked agar properties was compared. The water uptake was successfully reduced by crosslinking and its minimum values observed for DDI and HDI crosslinked agar was 33.6% and 43.6%, respectively in comparison to agar (206%). The maximum tensile strength was observed for DDI crosslinked agar (45.3 MPa) which was higher than HDI crosslinked agar (30.6 MPa) and agar (31.7 MPa). The aromatic diisocyanates crosslinked agar showed better thermal resistance at higher temperature. It was observed that aromatic diisocyanate crosslinked agar more effectively than the aliphatic diisocyanate due to the higher reactivity. The crosslinked agar samples were hemocompatible and show non-toxic nature for cell proliferation.

Original languageEnglish
Pages (from-to)454-460
JournalCarbohydrate Polymers
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed


  • Agar
  • Bioplastic
  • Crosslinking
  • Cytocompatibility
  • Hemocompatibility


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