Cryogenic chiral chromatography for rapid resolution of drug candidates

Martti Alkio, Olli Aaltonen (Corresponding Author), Harri Setälä

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.
Original languageEnglish
Pages (from-to)782 - 786
Number of pages5
JournalOrganic Process Research and Development
Volume9
Issue number6
DOIs
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fingerprint

Enantiomers
enantiomers
chromatography
Chromatography
Cryogenics
cryogenics
drugs
Pharmaceutical Preparations
Temperature
temperature

Keywords

  • chiral compounds
  • chiral chromatography
  • racemates
  • enantiomers

Cite this

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title = "Cryogenic chiral chromatography for rapid resolution of drug candidates",
abstract = "The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.",
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Cryogenic chiral chromatography for rapid resolution of drug candidates. / Alkio, Martti; Aaltonen, Olli (Corresponding Author); Setälä, Harri.

In: Organic Process Research and Development, Vol. 9, No. 6, 2005, p. 782 - 786.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Cryogenic chiral chromatography for rapid resolution of drug candidates

AU - Alkio, Martti

AU - Aaltonen, Olli

AU - Setälä, Harri

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AB - The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.

KW - chiral compounds

KW - chiral chromatography

KW - racemates

KW - enantiomers

U2 - 10.1021/op0501040

DO - 10.1021/op0501040

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JO - Organic Process Research and Development

JF - Organic Process Research and Development

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