Cryogenic chiral chromatography for rapid resolution of drug candidates

Martti Alkio; Olli Aaltonen; Harri Setälä

doi:10.1021/op0501040

Cryogenic chiral chromatography for rapid resolution of drug candidates

Martti Alkio, Olli Aaltonen (Corresponding Author), Harri Setälä

BA3604 Chemical process technologies

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.

Original language	English
Pages (from-to)	782 - 786
Number of pages	5
Journal	Organic Process Research and Development
Volume	9
Issue number	6
DOIs	https://doi.org/10.1021/op0501040
Publication status	Published - 2005
MoE publication type	A1 Journal article-refereed

Keywords

chiral compounds
chiral chromatography
racemates
enantiomers

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10.1021/op0501040

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Cite this

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title = "Cryogenic chiral chromatography for rapid resolution of drug candidates",

abstract = "The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions. ",

keywords = "chiral compounds, chiral chromatography, racemates, enantiomers",

author = "Martti Alkio and Olli Aaltonen and Harri Set{\"a}l{\"a}",

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T1 - Cryogenic chiral chromatography for rapid resolution of drug candidates

AU - Alkio, Martti

AU - Aaltonen, Olli

AU - Setälä, Harri

PY - 2005

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N2 - The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.

AB - The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.

KW - chiral compounds

KW - chiral chromatography

KW - racemates

KW - enantiomers

U2 - 10.1021/op0501040

DO - 10.1021/op0501040

M3 - Article

VL - 9

SP - 782

EP - 786

JO - Organic Process Research and Development

JF - Organic Process Research and Development

SN - 1083-6160

IS - 6

ER -