Cryogenic chiral chromatography for rapid resolution of drug candidates

Martti Alkio, Olli Aaltonen (Corresponding Author), Harri Setälä

    Research output: Contribution to journalArticleScientificpeer-review

    2 Citations (Scopus)


    The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.
    Original languageEnglish
    Pages (from-to)782 - 786
    Number of pages5
    JournalOrganic Process Research and Development
    Issue number6
    Publication statusPublished - 2005
    MoE publication typeA1 Journal article-refereed


    • chiral compounds
    • chiral chromatography
    • racemates
    • enantiomers


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