Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 782 - 786 |
| Number of pages | 5 |
| Journal | Organic Process Research and Development |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2005 |
| MoE publication type | A1 Journal article-refereed |
Fingerprint
Keywords
- chiral compounds
- chiral chromatography
- racemates
- enantiomers
Cite this
}
Cryogenic chiral chromatography for rapid resolution of drug candidates. / Alkio, Martti; Aaltonen, Olli (Corresponding Author); Setälä, Harri.
In: Organic Process Research and Development, Vol. 9, No. 6, 2005, p. 782 - 786.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Cryogenic chiral chromatography for rapid resolution of drug candidates
AU - Alkio, Martti
AU - Aaltonen, Olli
AU - Setälä, Harri
PY - 2005
Y1 - 2005
N2 - The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.
AB - The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.
KW - chiral compounds
KW - chiral chromatography
KW - racemates
KW - enantiomers
U2 - 10.1021/op0501040
DO - 10.1021/op0501040
M3 - Article
VL - 9
SP - 782
EP - 786
JO - Organic Process Research and Development
JF - Organic Process Research and Development
SN - 1083-6160
IS - 6
ER -