The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to −25 °C. In all examined cases the separation factor between the enantiomers increased with decreasing temperature. The yields and production rates for the enantiomers were calculated from chromatograms to predict optimum conditions for preparative resolutions.
- chiral compounds
- chiral chromatography
Alkio, M., Aaltonen, O., & Setälä, H. (2005). Cryogenic chiral chromatography for rapid resolution of drug candidates. Organic Process Research and Development, 9(6), 782 - 786. https://doi.org/10.1021/op0501040