Abstract
A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (1), 16-deoxyisoargentatin A (2), 7-oxoisoargentatin A (3), 24-epi-argentatin H (4), 24-O-p-anisoylargentatin C (5), 24-O-trans-cinnamoylargentatin C (6), 16-dehydroargentatin C (7), 16,17(20)-didehydroargentatin C (8), isoargentatin C (9), isoargentatin H (10), 3-epi-quisquagenin (11), and isoquisquagenin (12) together with 10 known triterpenoids (13-22) were isolated from the resin of Parthenium argentatum AZ-2 obtained as a byproduct of Bridgestone guayule rubber production. The structures of new triterpenoids 1-12 and argentatin H (13), which has previously been characterized as its diacetate (23), were elucidated by extensive analysis of their spectroscopic data and chemical conversions, and the known compounds 14-22 were identified by comparison of their spectroscopic data with those reported. Of these, 13, 14, and 18 exhibited weak cytotoxic activity for several cancer cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 15486-15498 |
| Journal | ACS Omega |
| Volume | 6 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 15 Jun 2021 |
| MoE publication type | A1 Journal article-refereed |
Funding
This project was supported by the USDA-NIFA (grant # 2017-68005-26867; Dr. Kimberly Ogden, PI) and Hatch projects 1005072 and 1020652 to A.A.L.G and I.M. We thank Dr. Lijiang Xuan, Shanghai Institute of Material Medica, Chinese Academy of Sciences, P. R. China for HRMS data.
