TY - JOUR
T1 - Cycloartane- And Lanostane-Type Triterpenoids from the Resin of Parthenium argentatum AZ-2, a Byproduct of Guayule Rubber Production
AU - Xu, Ya Ming
AU - Madasu, Chandrashekhar
AU - Liu, Manping X.
AU - Wijeratne, E. M.Kithsiri
AU - Dierig, David
AU - White, Bob
AU - Molnár, István
AU - Gunatilaka, A. A.Leslie
N1 - Funding Information:
This project was supported by the USDA-NIFA (grant # 2017-68005-26867; Dr. Kimberly Ogden, PI) and Hatch projects 1005072 and 1020652 to A.A.L.G and I.M. Any opinions, findings, conclusions, or recommendations expressed in this publication/work are those of the authors and do not necessarily reflect the view of the U.S. Department of Agriculture. We thank Dr. Lijiang Xuan, Shanghai Institute of Material Medica, Chinese Academy of Sciences, P. R. China for HRMS data.
Publisher Copyright:
© 2021 The Authors. Published by American Chemical Society.
PY - 2021/6/15
Y1 - 2021/6/15
N2 - A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (1), 16-deoxyisoargentatin A (2), 7-oxoisoargentatin A (3), 24-epi-argentatin H (4), 24-O-p-anisoylargentatin C (5), 24-O-trans-cinnamoylargentatin C (6), 16-dehydroargentatin C (7), 16,17(20)-didehydroargentatin C (8), isoargentatin C (9), isoargentatin H (10), 3-epi-quisquagenin (11), and isoquisquagenin (12) together with 10 known triterpenoids (13-22) were isolated from the resin of Parthenium argentatum AZ-2 obtained as a byproduct of Bridgestone guayule rubber production. The structures of new triterpenoids 1-12 and argentatin H (13), which has previously been characterized as its diacetate (23), were elucidated by extensive analysis of their spectroscopic data and chemical conversions, and the known compounds 14-22 were identified by comparison of their spectroscopic data with those reported. Of these, 13, 14, and 18 exhibited weak cytotoxic activity for several cancer cell lines.
AB - A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (1), 16-deoxyisoargentatin A (2), 7-oxoisoargentatin A (3), 24-epi-argentatin H (4), 24-O-p-anisoylargentatin C (5), 24-O-trans-cinnamoylargentatin C (6), 16-dehydroargentatin C (7), 16,17(20)-didehydroargentatin C (8), isoargentatin C (9), isoargentatin H (10), 3-epi-quisquagenin (11), and isoquisquagenin (12) together with 10 known triterpenoids (13-22) were isolated from the resin of Parthenium argentatum AZ-2 obtained as a byproduct of Bridgestone guayule rubber production. The structures of new triterpenoids 1-12 and argentatin H (13), which has previously been characterized as its diacetate (23), were elucidated by extensive analysis of their spectroscopic data and chemical conversions, and the known compounds 14-22 were identified by comparison of their spectroscopic data with those reported. Of these, 13, 14, and 18 exhibited weak cytotoxic activity for several cancer cell lines.
UR - http://www.scopus.com/inward/record.url?scp=85108541658&partnerID=8YFLogxK
U2 - 10.1021/acsomega.1c01714
DO - 10.1021/acsomega.1c01714
M3 - Article
AN - SCOPUS:85108541658
VL - 6
SP - 15486
EP - 15498
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 23
ER -
