Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices

Hannes Orelma (Corresponding Author), Tommi Virtanen, Steven Spoljaric, Jani Lehmonen, Jukka Seppälä, Orlando J. Rojas, Ali Harlin

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)

Abstract

A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutectic solution (DES) of cellulose in choline chloride-urea. Despite their high porosity and water sorption capacity (5 g/g), the spun fiber yarns displayed high wet strength, up to 60% of that recorded in dry condition (128 MPa with 17% strain at break). Cyclodextrin irreversible attachment on the yarns was achieved with adsorbed chitosan and the conjugation reactions and capture of EE2 by the cyclodextrin-modified cellulose were confirmed via online detection with Surface Plasmon Resonance (SPR). The facile synthesis of the bioactive yarns and EE2 binding capacity from aqueous matrices (as high as 2.5 mg/g) indicate excellent prospects for inexpensive platforms in disposable affinity filtration. The study presents a strategy to produce a wood fiber based yarn to be used as a platform for human and veterinary pharmaceutical hormone capture.

Original languageEnglish
Pages (from-to)652-661
Number of pages10
JournalBiomacromolecules
Volume19
Issue number2
DOIs
Publication statusPublished - 12 Feb 2018
MoE publication typeA1 Journal article-refereed

Fingerprint

Cyclodextrins
Hormones
Cellulose
Eutectics
Yarn
Fibers
Drug products
Water
Wood
Veterinary Drugs
Estradiol Congeners
Ethinyl Estradiol
Chitosan
Surface plasmon resonance
Contraceptive Agents
Choline
Urea
Sorption
Porosity
Molecules

Cite this

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title = "Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices",
abstract = "A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutectic solution (DES) of cellulose in choline chloride-urea. Despite their high porosity and water sorption capacity (5 g/g), the spun fiber yarns displayed high wet strength, up to 60{\%} of that recorded in dry condition (128 MPa with 17{\%} strain at break). Cyclodextrin irreversible attachment on the yarns was achieved with adsorbed chitosan and the conjugation reactions and capture of EE2 by the cyclodextrin-modified cellulose were confirmed via online detection with Surface Plasmon Resonance (SPR). The facile synthesis of the bioactive yarns and EE2 binding capacity from aqueous matrices (as high as 2.5 mg/g) indicate excellent prospects for inexpensive platforms in disposable affinity filtration. The study presents a strategy to produce a wood fiber based yarn to be used as a platform for human and veterinary pharmaceutical hormone capture.",
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Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices. / Orelma, Hannes (Corresponding Author); Virtanen, Tommi; Spoljaric, Steven; Lehmonen, Jani; Seppälä, Jukka; Rojas, Orlando J.; Harlin, Ali.

In: Biomacromolecules, Vol. 19, No. 2, 12.02.2018, p. 652-661.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Orelma, Hannes

AU - Virtanen, Tommi

AU - Spoljaric, Steven

AU - Lehmonen, Jani

AU - Seppälä, Jukka

AU - Rojas, Orlando J.

AU - Harlin, Ali

PY - 2018/2/12

Y1 - 2018/2/12

N2 - A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutectic solution (DES) of cellulose in choline chloride-urea. Despite their high porosity and water sorption capacity (5 g/g), the spun fiber yarns displayed high wet strength, up to 60% of that recorded in dry condition (128 MPa with 17% strain at break). Cyclodextrin irreversible attachment on the yarns was achieved with adsorbed chitosan and the conjugation reactions and capture of EE2 by the cyclodextrin-modified cellulose were confirmed via online detection with Surface Plasmon Resonance (SPR). The facile synthesis of the bioactive yarns and EE2 binding capacity from aqueous matrices (as high as 2.5 mg/g) indicate excellent prospects for inexpensive platforms in disposable affinity filtration. The study presents a strategy to produce a wood fiber based yarn to be used as a platform for human and veterinary pharmaceutical hormone capture.

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