Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

F. Dortu, H. Egger, Kai Kolari, Tomi Haatainen, P. Furjes, Z. Fekete, D. Bernier, G. Sharp, B. Lahiri, S. Kurunczi, J.-C. Sanchez, N. Turcj, P. Petrik, D. Patko, R. Horvath, S. Eiden, Timo Aalto

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

7 Citations (Scopus)

Abstract

In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors
Original languageEnglish
Title of host publicationClinical and Biomedical Spectroscopy and Imaging II
EditorsRamanujam Nirmala
PublisherInternational Society for Optics and Photonics SPIE
Number of pages17
ISBN (Print)978-0-8194-8684-4
DOIs
Publication statusPublished - 2011
MoE publication typeA4 Article in a conference publication
EventClinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics - Munich, Germany
Duration: 24 May 201126 May 2011

Publication series

SeriesProceedings of SPIE
Volume8087
ISSN0277-786X

Conference

ConferenceClinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics
CountryGermany
CityMunich
Period24/05/1126/05/11

Fingerprint

bioinstrumentation
chips
photonics
polymers
crystals
fluidics
sensors
European Union
cavity resonators
polyimides
Q factors
nanocomposites
adhesion
lithography
refractivity
waveguides
requirements
fabrication
thin films

Keywords

  • Biosensor
  • lab-on-a-chip
  • nanocomposites
  • nanoimprint lithography
  • photonic crystal
  • point-of-care diagnostics
  • polyimide
  • polymer

Cite this

Dortu, F., Egger, H., Kolari, K., Haatainen, T., Furjes, P., Fekete, Z., ... Aalto, T. (2011). Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. In R. Nirmala (Ed.), Clinical and Biomedical Spectroscopy and Imaging II [80870D] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 8087 https://doi.org/10.1117/12.889420
Dortu, F. ; Egger, H. ; Kolari, Kai ; Haatainen, Tomi ; Furjes, P. ; Fekete, Z. ; Bernier, D. ; Sharp, G. ; Lahiri, B. ; Kurunczi, S. ; Sanchez, J.-C. ; Turcj, N. ; Petrik, P. ; Patko, D. ; Horvath, R. ; Eiden, S. ; Aalto, Timo. / Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. Clinical and Biomedical Spectroscopy and Imaging II. editor / Ramanujam Nirmala. International Society for Optics and Photonics SPIE, 2011. (Proceedings of SPIE, Vol. 8087).
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title = "Design and process development of a photonic crystal polymer biosensor for point of care diagnostics",
abstract = "In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors",
keywords = "Biosensor, lab-on-a-chip, nanocomposites, nanoimprint lithography, photonic crystal, point-of-care diagnostics, polyimide, polymer",
author = "F. Dortu and H. Egger and Kai Kolari and Tomi Haatainen and P. Furjes and Z. Fekete and D. Bernier and G. Sharp and B. Lahiri and S. Kurunczi and J.-C. Sanchez and N. Turcj and P. Petrik and D. Patko and R. Horvath and S. Eiden and Timo Aalto",
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Dortu, F, Egger, H, Kolari, K, Haatainen, T, Furjes, P, Fekete, Z, Bernier, D, Sharp, G, Lahiri, B, Kurunczi, S, Sanchez, J-C, Turcj, N, Petrik, P, Patko, D, Horvath, R, Eiden, S & Aalto, T 2011, Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. in R Nirmala (ed.), Clinical and Biomedical Spectroscopy and Imaging II., 80870D, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 8087, Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics , Munich, Germany, 24/05/11. https://doi.org/10.1117/12.889420

Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. / Dortu, F.; Egger, H.; Kolari, Kai; Haatainen, Tomi; Furjes, P.; Fekete, Z.; Bernier, D.; Sharp, G.; Lahiri, B.; Kurunczi, S.; Sanchez, J.-C.; Turcj, N.; Petrik, P.; Patko, D.; Horvath, R.; Eiden, S.; Aalto, Timo.

Clinical and Biomedical Spectroscopy and Imaging II. ed. / Ramanujam Nirmala. International Society for Optics and Photonics SPIE, 2011. 80870D (Proceedings of SPIE, Vol. 8087).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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T1 - Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

AU - Dortu, F.

AU - Egger, H.

AU - Kolari, Kai

AU - Haatainen, Tomi

AU - Furjes, P.

AU - Fekete, Z.

AU - Bernier, D.

AU - Sharp, G.

AU - Lahiri, B.

AU - Kurunczi, S.

AU - Sanchez, J.-C.

AU - Turcj, N.

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AU - Patko, D.

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KW - Biosensor

KW - lab-on-a-chip

KW - nanocomposites

KW - nanoimprint lithography

KW - photonic crystal

KW - point-of-care diagnostics

KW - polyimide

KW - polymer

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DO - 10.1117/12.889420

M3 - Conference article in proceedings

SN - 978-0-8194-8684-4

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BT - Clinical and Biomedical Spectroscopy and Imaging II

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PB - International Society for Optics and Photonics SPIE

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Dortu F, Egger H, Kolari K, Haatainen T, Furjes P, Fekete Z et al. Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. In Nirmala R, editor, Clinical and Biomedical Spectroscopy and Imaging II. International Society for Optics and Photonics SPIE. 2011. 80870D. (Proceedings of SPIE, Vol. 8087). https://doi.org/10.1117/12.889420