Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

F. Dortu, H. Egger, Kai Kolari, Tomi Haatainen, P. Furjes, Z. Fekete, D. Bernier, G. Sharp, B. Lahiri, S. Kurunczi, J.-C. Sanchez, N. Turcj, P. Petrik, D. Patko, R. Horvath, S. Eiden, Timo Aalto

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    8 Citations (Scopus)

    Abstract

    In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors
    Original languageEnglish
    Title of host publicationClinical and Biomedical Spectroscopy and Imaging II
    EditorsRamanujam Nirmala
    PublisherInternational Society for Optics and Photonics SPIE
    Number of pages17
    ISBN (Print)978-0-8194-8684-4
    DOIs
    Publication statusPublished - 2011
    MoE publication typeA4 Article in a conference publication
    EventClinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics - Munich, Germany
    Duration: 24 May 201126 May 2011

    Publication series

    SeriesProceedings of SPIE
    Volume8087
    ISSN0277-786X

    Conference

    ConferenceClinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics
    CountryGermany
    CityMunich
    Period24/05/1126/05/11

    Fingerprint

    bioinstrumentation
    chips
    photonics
    polymers
    crystals
    fluidics
    sensors
    European Union
    cavity resonators
    polyimides
    Q factors
    nanocomposites
    adhesion
    lithography
    refractivity
    waveguides
    requirements
    fabrication
    thin films

    Keywords

    • Biosensor
    • lab-on-a-chip
    • nanocomposites
    • nanoimprint lithography
    • photonic crystal
    • point-of-care diagnostics
    • polyimide
    • polymer

    Cite this

    Dortu, F., Egger, H., Kolari, K., Haatainen, T., Furjes, P., Fekete, Z., ... Aalto, T. (2011). Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. In R. Nirmala (Ed.), Clinical and Biomedical Spectroscopy and Imaging II [80870D] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 8087 https://doi.org/10.1117/12.889420
    Dortu, F. ; Egger, H. ; Kolari, Kai ; Haatainen, Tomi ; Furjes, P. ; Fekete, Z. ; Bernier, D. ; Sharp, G. ; Lahiri, B. ; Kurunczi, S. ; Sanchez, J.-C. ; Turcj, N. ; Petrik, P. ; Patko, D. ; Horvath, R. ; Eiden, S. ; Aalto, Timo. / Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. Clinical and Biomedical Spectroscopy and Imaging II. editor / Ramanujam Nirmala. International Society for Optics and Photonics SPIE, 2011. (Proceedings of SPIE, Vol. 8087).
    @inproceedings{0d14319b99b74d1e82477819dc3a24b4,
    title = "Design and process development of a photonic crystal polymer biosensor for point of care diagnostics",
    abstract = "In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors",
    keywords = "Biosensor, lab-on-a-chip, nanocomposites, nanoimprint lithography, photonic crystal, point-of-care diagnostics, polyimide, polymer",
    author = "F. Dortu and H. Egger and Kai Kolari and Tomi Haatainen and P. Furjes and Z. Fekete and D. Bernier and G. Sharp and B. Lahiri and S. Kurunczi and J.-C. Sanchez and N. Turcj and P. Petrik and D. Patko and R. Horvath and S. Eiden and Timo Aalto",
    year = "2011",
    doi = "10.1117/12.889420",
    language = "English",
    isbn = "978-0-8194-8684-4",
    series = "Proceedings of SPIE",
    publisher = "International Society for Optics and Photonics SPIE",
    editor = "Ramanujam Nirmala",
    booktitle = "Clinical and Biomedical Spectroscopy and Imaging II",
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    }

    Dortu, F, Egger, H, Kolari, K, Haatainen, T, Furjes, P, Fekete, Z, Bernier, D, Sharp, G, Lahiri, B, Kurunczi, S, Sanchez, J-C, Turcj, N, Petrik, P, Patko, D, Horvath, R, Eiden, S & Aalto, T 2011, Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. in R Nirmala (ed.), Clinical and Biomedical Spectroscopy and Imaging II., 80870D, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 8087, Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics , Munich, Germany, 24/05/11. https://doi.org/10.1117/12.889420

    Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. / Dortu, F.; Egger, H.; Kolari, Kai; Haatainen, Tomi; Furjes, P.; Fekete, Z.; Bernier, D.; Sharp, G.; Lahiri, B.; Kurunczi, S.; Sanchez, J.-C.; Turcj, N.; Petrik, P.; Patko, D.; Horvath, R.; Eiden, S.; Aalto, Timo.

    Clinical and Biomedical Spectroscopy and Imaging II. ed. / Ramanujam Nirmala. International Society for Optics and Photonics SPIE, 2011. 80870D (Proceedings of SPIE, Vol. 8087).

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    TY - GEN

    T1 - Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

    AU - Dortu, F.

    AU - Egger, H.

    AU - Kolari, Kai

    AU - Haatainen, Tomi

    AU - Furjes, P.

    AU - Fekete, Z.

    AU - Bernier, D.

    AU - Sharp, G.

    AU - Lahiri, B.

    AU - Kurunczi, S.

    AU - Sanchez, J.-C.

    AU - Turcj, N.

    AU - Petrik, P.

    AU - Patko, D.

    AU - Horvath, R.

    AU - Eiden, S.

    AU - Aalto, Timo

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    N2 - In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors

    AB - In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors

    KW - Biosensor

    KW - lab-on-a-chip

    KW - nanocomposites

    KW - nanoimprint lithography

    KW - photonic crystal

    KW - point-of-care diagnostics

    KW - polyimide

    KW - polymer

    U2 - 10.1117/12.889420

    DO - 10.1117/12.889420

    M3 - Conference article in proceedings

    SN - 978-0-8194-8684-4

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    BT - Clinical and Biomedical Spectroscopy and Imaging II

    A2 - Nirmala, Ramanujam

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    ER -

    Dortu F, Egger H, Kolari K, Haatainen T, Furjes P, Fekete Z et al. Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. In Nirmala R, editor, Clinical and Biomedical Spectroscopy and Imaging II. International Society for Optics and Photonics SPIE. 2011. 80870D. (Proceedings of SPIE, Vol. 8087). https://doi.org/10.1117/12.889420