Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

F. Dortu; H. Egger; Kai Kolari; Tomi Haatainen; P. Furjes; Z. Fekete; D. Bernier; G. Sharp; B. Lahiri; S. Kurunczi; J.-C. Sanchez; N. Turcj; P. Petrik; D. Patko; R. Horvath; S. Eiden; Timo Aalto

doi:10.1117/12.889420

Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

F. Dortu
, H. Egger
, Kai Kolari
, Tomi Haatainen
, P. Furjes
, Z. Fekete
, D. Bernier
, G. Sharp
, B. Lahiri
, S. Kurunczi
, J.-C. Sanchez
, N. Turcj
, P. Petrik
, D. Patko
, R. Horvath
, S. Eiden
, Timo Aalto

Multitel Research Centre
Bayer Technology Services GmbH
Institute for Technical Physics and Materials Science
University of Glasgow
University of Geneva
Stratophase Ltd
University of Malaya

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

9 Citations (Scopus)

Abstract

In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors

Original language	English
Title of host publication	Clinical and Biomedical Spectroscopy and Imaging II
Editors	Ramanujam Nirmala
Publisher	International Society for Optics and Photonics SPIE
Number of pages	17
ISBN (Print)	978-0-8194-8684-4
DOIs	https://doi.org/10.1117/12.889420
Publication status	Published - 2011
MoE publication type	A4 Article in a conference publication
Event	Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics - Munich, Germany Duration: 24 May 2011 → 26 May 2011

Publication series

Series	Proceedings of SPIE
Volume	8087
ISSN	0277-786X

Conference

Conference	Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics
Country/Territory	Germany
City	Munich
Period	24/05/11 → 26/05/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

Biosensor
lab-on-a-chip
nanocomposites
nanoimprint lithography
photonic crystal
point-of-care diagnostics
polyimide
polymer

Access to Document

10.1117/12.889420

Cite this

Dortu, F., Egger, H., Kolari, K., Haatainen, T., Furjes, P., Fekete, Z., Bernier, D., Sharp, G., Lahiri, B., Kurunczi, S., Sanchez, J.-C., Turcj, N., Petrik, P., Patko, D., Horvath, R., Eiden, S., & Aalto, T. (2011). Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. In R. Nirmala (Ed.), Clinical and Biomedical Spectroscopy and Imaging II Article 80870D International Society for Optics and Photonics SPIE. https://doi.org/10.1117/12.889420

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title = "Design and process development of a photonic crystal polymer biosensor for point of care diagnostics",

abstract = "In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors",

keywords = "Biosensor, lab-on-a-chip, nanocomposites, nanoimprint lithography, photonic crystal, point-of-care diagnostics, polyimide, polymer",

author = "F. Dortu and H. Egger and Kai Kolari and Tomi Haatainen and P. Furjes and Z. Fekete and D. Bernier and G. Sharp and B. Lahiri and S. Kurunczi and J.-C. Sanchez and N. Turcj and P. Petrik and D. Patko and R. Horvath and S. Eiden and Timo Aalto",

year = "2011",

doi = "10.1117/12.889420",

language = "English",

isbn = "978-0-8194-8684-4",

series = "Proceedings of SPIE",

publisher = "International Society for Optics and Photonics SPIE",

editor = "Ramanujam Nirmala",

booktitle = "Clinical and Biomedical Spectroscopy and Imaging II",

address = "United States",

note = "Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics ; Conference date: 24-05-2011 Through 26-05-2011",

}

Dortu, F, Egger, H, Kolari, K, Haatainen, T, Furjes, P, Fekete, Z, Bernier, D, Sharp, G, Lahiri, B, Kurunczi, S, Sanchez, J-C, Turcj, N, Petrik, P, Patko, D, Horvath, R, Eiden, S & Aalto, T 2011, Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. in R Nirmala (ed.), Clinical and Biomedical Spectroscopy and Imaging II., 80870D, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 8087, Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics , Munich, Germany, 24/05/11. https://doi.org/10.1117/12.889420

Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. / Dortu, F.; Egger, H.; Kolari, Kai et al.
Clinical and Biomedical Spectroscopy and Imaging II. ed. / Ramanujam Nirmala. International Society for Optics and Photonics SPIE, 2011. 80870D (Proceedings of SPIE, Vol. 8087).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

AU - Dortu, F.

AU - Egger, H.

AU - Kolari, Kai

AU - Haatainen, Tomi

AU - Furjes, P.

AU - Fekete, Z.

AU - Bernier, D.

AU - Sharp, G.

AU - Lahiri, B.

AU - Kurunczi, S.

AU - Sanchez, J.-C.

AU - Turcj, N.

AU - Petrik, P.

AU - Patko, D.

AU - Horvath, R.

AU - Eiden, S.

AU - Aalto, Timo

PY - 2011

Y1 - 2011

N2 - In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors

AB - In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors

KW - Biosensor

KW - lab-on-a-chip

KW - nanocomposites

KW - nanoimprint lithography

KW - photonic crystal

KW - point-of-care diagnostics

KW - polyimide

KW - polymer

U2 - 10.1117/12.889420

DO - 10.1117/12.889420

M3 - Conference article in proceedings

SN - 978-0-8194-8684-4

T3 - Proceedings of SPIE

BT - Clinical and Biomedical Spectroscopy and Imaging II

A2 - Nirmala, Ramanujam

PB - International Society for Optics and Photonics SPIE

T2 - Clinical and Biomedical Spectroscopy and Imaging II. European Conferences on Biomedical Optics

Y2 - 24 May 2011 through 26 May 2011

ER -

Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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