Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Lara Gazzera, Roberto Milani, Lisa Pirrie, Marc Schmutz, Christian Blanck, Giuseppe Resnati, Pierangelo Metrangolo (Corresponding Author), Marie Pierre Krafft (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    9 Citations (Scopus)

    Abstract

    Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.
    Original languageEnglish
    Pages (from-to)10263-10267
    JournalAngewandte Chemie: International Edition
    Volume55
    Issue number35
    DOIs
    Publication statusPublished - 2016
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Air
    Gases
    Adsorption
    Fluorocarbons
    Langmuir Blodgett films
    Elasticity
    Monolayers
    Agglomeration
    Phase transitions
    Fluids
    Water
    perflexane

    Keywords

    • echogenicity
    • fluorocarbons
    • hydrophobin
    • interfacial films
    • ultrasound imaging

    Cite this

    Gazzera, Lara ; Milani, Roberto ; Pirrie, Lisa ; Schmutz, Marc ; Blanck, Christian ; Resnati, Giuseppe ; Metrangolo, Pierangelo ; Krafft, Marie Pierre. / Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell. In: Angewandte Chemie: International Edition. 2016 ; Vol. 55, No. 35. pp. 10263-10267.
    @article{ac5f903581e543fb925d04e00d15e751,
    title = "Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell",
    abstract = "Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.",
    keywords = "echogenicity, fluorocarbons, hydrophobin, interfacial films, ultrasound imaging",
    author = "Lara Gazzera and Roberto Milani and Lisa Pirrie and Marc Schmutz and Christian Blanck and Giuseppe Resnati and Pierangelo Metrangolo and Krafft, {Marie Pierre}",
    year = "2016",
    doi = "10.1002/anie.201603706",
    language = "English",
    volume = "55",
    pages = "10263--10267",
    journal = "Angewandte Chemie: International Edition",
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    Gazzera, L, Milani, R, Pirrie, L, Schmutz, M, Blanck, C, Resnati, G, Metrangolo, P & Krafft, MP 2016, 'Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell', Angewandte Chemie: International Edition, vol. 55, no. 35, pp. 10263-10267. https://doi.org/10.1002/anie.201603706

    Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell. / Gazzera, Lara; Milani, Roberto; Pirrie, Lisa; Schmutz, Marc; Blanck, Christian; Resnati, Giuseppe; Metrangolo, Pierangelo (Corresponding Author); Krafft, Marie Pierre (Corresponding Author).

    In: Angewandte Chemie: International Edition, Vol. 55, No. 35, 2016, p. 10263-10267.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

    AU - Gazzera, Lara

    AU - Milani, Roberto

    AU - Pirrie, Lisa

    AU - Schmutz, Marc

    AU - Blanck, Christian

    AU - Resnati, Giuseppe

    AU - Metrangolo, Pierangelo

    AU - Krafft, Marie Pierre

    PY - 2016

    Y1 - 2016

    N2 - Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

    AB - Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

    KW - echogenicity

    KW - fluorocarbons

    KW - hydrophobin

    KW - interfacial films

    KW - ultrasound imaging

    U2 - 10.1002/anie.201603706

    DO - 10.1002/anie.201603706

    M3 - Article

    VL - 55

    SP - 10263

    EP - 10267

    JO - Angewandte Chemie: International Edition

    JF - Angewandte Chemie: International Edition

    SN - 1433-7851

    IS - 35

    ER -