Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Lara Gazzera, Roberto Milani, Lisa Pirrie, Marc Schmutz, Christian Blanck, Giuseppe Resnati, Pierangelo Metrangolo (Corresponding Author), Marie Pierre Krafft (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    14 Citations (Scopus)

    Abstract

    Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.
    Original languageEnglish
    Pages (from-to)10263-10267
    JournalAngewandte Chemie: International Edition
    Volume55
    Issue number35
    DOIs
    Publication statusPublished - 2016
    MoE publication typeA1 Journal article-refereed

    Keywords

    • echogenicity
    • fluorocarbons
    • hydrophobin
    • interfacial films
    • ultrasound imaging

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