Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Lara Gazzera; Roberto Milani; Lisa Pirrie; Marc Schmutz; Christian Blanck; Giuseppe Resnati; Pierangelo Metrangolo; Marie Pierre Krafft

doi:10.1002/anie.201603706

Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Lara Gazzera, Roberto Milani, Lisa Pirrie, Marc Schmutz, Christian Blanck, Giuseppe Resnati, Pierangelo Metrangolo (Corresponding Author), Marie Pierre Krafft (Corresponding Author)

Research output: Contribution to journal › Article › Scientific › peer-review

15 Citations (Scopus)

Abstract

Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

Original language	English
Pages (from-to)	10263-10267
Journal	Angewandte Chemie: International Edition
Volume	55
Issue number	35
DOIs	https://doi.org/10.1002/anie.201603706
Publication status	Published - 2016
MoE publication type	A1 Journal article-refereed

Keywords

echogenicity
fluorocarbons
hydrophobin
interfacial films
ultrasound imaging

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10.1002/anie.201603706

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@article{ac5f903581e543fb925d04e00d15e751,

title = "Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell",

abstract = "Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.",

keywords = "echogenicity, fluorocarbons, hydrophobin, interfacial films, ultrasound imaging",

author = "Lara Gazzera and Roberto Milani and Lisa Pirrie and Marc Schmutz and Christian Blanck and Giuseppe Resnati and Pierangelo Metrangolo and Krafft, {Marie Pierre}",

year = "2016",

doi = "10.1002/anie.201603706",

language = "English",

volume = "55",

pages = "10263--10267",

journal = "Angewandte Chemie: International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "35",

}

Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell. / Gazzera, Lara; Milani, Roberto; Pirrie, Lisa; Schmutz, Marc; Blanck, Christian; Resnati, Giuseppe; Metrangolo, Pierangelo (Corresponding Author); Krafft, Marie Pierre (Corresponding Author).

In: Angewandte Chemie: International Edition, Vol. 55, No. 35, 2016, p. 10263-10267.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

AU - Gazzera, Lara

AU - Milani, Roberto

AU - Pirrie, Lisa

AU - Schmutz, Marc

AU - Blanck, Christian

AU - Resnati, Giuseppe

AU - Metrangolo, Pierangelo

AU - Krafft, Marie Pierre

PY - 2016

Y1 - 2016

N2 - Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

AB - Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

KW - echogenicity

KW - fluorocarbons

KW - hydrophobin

KW - interfacial films

KW - ultrasound imaging

U2 - 10.1002/anie.201603706

DO - 10.1002/anie.201603706

M3 - Article

VL - 55

SP - 10263

EP - 10267

JO - Angewandte Chemie: International Edition

JF - Angewandte Chemie: International Edition

SN - 1433-7851

IS - 35

ER -