Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Lara Gazzera; Roberto Milani; Lisa Pirrie; Marc Schmutz; Christian Blanck; Giuseppe Resnati; Pierangelo Metrangolo; Marie Pierre Krafft

doi:10.1002/anie.201603706

Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Lara Gazzera, Roberto Milani, Lisa Pirrie, Marc Schmutz, Christian Blanck, Giuseppe Resnati, Pierangelo Metrangolo^*, Marie Pierre Krafft^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

23 Citations (Scopus)

Abstract

Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

Original language	English
Pages (from-to)	10263-10267
Journal	Angewandte Chemie: International Edition
Volume	55
Issue number	35
DOIs	https://doi.org/10.1002/anie.201603706
Publication status	Published - 2016
MoE publication type	A1 Journal article-refereed

Keywords

echogenicity
fluorocarbons
hydrophobin
interfacial films
ultrasound imaging

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10.1002/anie.201603706

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title = "Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell",

abstract = "Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.",

keywords = "echogenicity, fluorocarbons, hydrophobin, interfacial films, ultrasound imaging",

author = "Lara Gazzera and Roberto Milani and Lisa Pirrie and Marc Schmutz and Christian Blanck and Giuseppe Resnati and Pierangelo Metrangolo and Krafft, {Marie Pierre}",

year = "2016",

doi = "10.1002/anie.201603706",

language = "English",

volume = "55",

pages = "10263--10267",

journal = "Angewandte Chemie: International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "35",

}

TY - JOUR

T1 - Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

AU - Gazzera, Lara

AU - Milani, Roberto

AU - Pirrie, Lisa

AU - Schmutz, Marc

AU - Blanck, Christian

AU - Resnati, Giuseppe

AU - Metrangolo, Pierangelo

AU - Krafft, Marie Pierre

PY - 2016

Y1 - 2016

N2 - Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

AB - Dispersing hydrophobin HFBII under air saturated with perfluorohexane gas limits HFBII aggregation to nanometer-sizes. Critical basic findings include an unusual co-adsorption effect caused by the fluorocarbon gas, a strong acceleration of HFBII adsorption at the air/water interface, the incorporation of perfluorohexane into the interfacial film, the suppression of the fluid-to-solid 2D phase transition exhibited by HFBII monolayers under air, and a drastic change in film elasticity of both Gibbs and Langmuir films. As a result, perfluorohexane allows the formation of homogenous populations of spherical, narrowly dispersed, exceptionally stable, and echogenic microbubbles.

KW - echogenicity

KW - fluorocarbons

KW - hydrophobin

KW - interfacial films

KW - ultrasound imaging

U2 - 10.1002/anie.201603706

DO - 10.1002/anie.201603706

M3 - Article

SN - 1433-7851

VL - 55

SP - 10263

EP - 10267

JO - Angewandte Chemie: International Edition

JF - Angewandte Chemie: International Edition

IS - 35

ER -

Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell

Abstract

Keywords

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