Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization

Raimo Ketola, Frants Lauritsen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

In order to detect highly polar organic compounds in water using membrane inlet mass spectrometry (MIMS), we designed a desorption chemical ionization ion source with a tubular polyacrylonitrile membrane positioned in the center of the chemical ionization (Cl) ion plasma. With this system we have for the first time been able to detect dicarboxylic acids (malonic and succinic acid) in aqueous samples with a MIMS system. The dicarboxylic acids were detected with both standard MIMS and trap‐and‐release MIMS methods. The trap‐and‐release MIMS method gave the best signal to noise ratio spectra with detection limits down to 50 mg/L. Although the results presented are very preliminary, they suggest that rapid detection or even on‐line monitoring of this important group of biological metabolites might be possible with a MIMS system.
Original languageEnglish
Pages (from-to)749-751
Number of pages3
JournalRapid Communications in Mass Spectrometry
Volume13
Issue number8
DOIs
Publication statusPublished - 1999
MoE publication typeA1 Journal article-refereed

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Dicarboxylic Acids
Ionization
Mass spectrometry
Desorption
Membranes
Ion sources
Succinic Acid
Metabolites
Organic compounds
Signal to noise ratio
Ions
Plasmas
Water
Monitoring

Cite this

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title = "Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization",
abstract = "In order to detect highly polar organic compounds in water using membrane inlet mass spectrometry (MIMS), we designed a desorption chemical ionization ion source with a tubular polyacrylonitrile membrane positioned in the center of the chemical ionization (Cl) ion plasma. With this system we have for the first time been able to detect dicarboxylic acids (malonic and succinic acid) in aqueous samples with a MIMS system. The dicarboxylic acids were detected with both standard MIMS and trap‐and‐release MIMS methods. The trap‐and‐release MIMS method gave the best signal to noise ratio spectra with detection limits down to 50 mg/L. Although the results presented are very preliminary, they suggest that rapid detection or even on‐line monitoring of this important group of biological metabolites might be possible with a MIMS system.",
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Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization. / Ketola, Raimo; Lauritsen, Frants (Corresponding Author).

In: Rapid Communications in Mass Spectrometry, Vol. 13, No. 8, 1999, p. 749-751.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Detection of dicarboxylic acids in aqueous samples using membrane inlet mass spectrometry with desorption chemical ionization

AU - Ketola, Raimo

AU - Lauritsen, Frants

PY - 1999

Y1 - 1999

N2 - In order to detect highly polar organic compounds in water using membrane inlet mass spectrometry (MIMS), we designed a desorption chemical ionization ion source with a tubular polyacrylonitrile membrane positioned in the center of the chemical ionization (Cl) ion plasma. With this system we have for the first time been able to detect dicarboxylic acids (malonic and succinic acid) in aqueous samples with a MIMS system. The dicarboxylic acids were detected with both standard MIMS and trap‐and‐release MIMS methods. The trap‐and‐release MIMS method gave the best signal to noise ratio spectra with detection limits down to 50 mg/L. Although the results presented are very preliminary, they suggest that rapid detection or even on‐line monitoring of this important group of biological metabolites might be possible with a MIMS system.

AB - In order to detect highly polar organic compounds in water using membrane inlet mass spectrometry (MIMS), we designed a desorption chemical ionization ion source with a tubular polyacrylonitrile membrane positioned in the center of the chemical ionization (Cl) ion plasma. With this system we have for the first time been able to detect dicarboxylic acids (malonic and succinic acid) in aqueous samples with a MIMS system. The dicarboxylic acids were detected with both standard MIMS and trap‐and‐release MIMS methods. The trap‐and‐release MIMS method gave the best signal to noise ratio spectra with detection limits down to 50 mg/L. Although the results presented are very preliminary, they suggest that rapid detection or even on‐line monitoring of this important group of biological metabolites might be possible with a MIMS system.

U2 - 10.1002/(SICI)1097-0231(19990430)13:8<749::AID-RCM553>3.0.CO;2-B

DO - 10.1002/(SICI)1097-0231(19990430)13:8<749::AID-RCM553>3.0.CO;2-B

M3 - Article

VL - 13

SP - 749

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JO - Rapid Communications in Mass Spectrometry

JF - Rapid Communications in Mass Spectrometry

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